dr hab. inż. Katarzyna Błażewska, prof. uczelni
dr Katarzyna Justyna
mgr inż. Łukasz Joachimiak
mgr inż. Joanna Gmach
mgr inż. Damian Kusy
Współpraca: Wydział Biotechnologii i Nauk o Żywności:
dr hab. Edyta Gendaszewska-Darmach; mgr inż. Aleksandra Marchwicka
Nasze badania koncentrują się na syntezie i poszukiwaniu związków aktywnych względem enzymów Rab GGTazy oraz Rab GTPaz, z wykorzystaniem narzędzi biologii chemicznej oraz chemii medycznej. Zaburzone działanie tych enzymów obserwowane jest w chorobach neurodegeneracyjnych, nowotworowych oraz zakaźnych, dlatego stanowią one potencjalny cel terapeutyczny.
Poszukiwanie nowych inhibitorów. Badania zależności struktura – aktywność |
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asrKyXlxcOh0tPTxcSEmpsbPzULTU1NR0/flxNTW2JCbLEBLa1tXV0dPT394+Li0Oj0Z6enuTgb2hoaHh4OORvWRPksy4Y8LXYEQiE5ubm5ubmmpqa7z/5LYYPQRApKamxsTH4fzc3t0OHDpG/D/Pz883NzQcOHGhpaXFzcxMVFfX19ZWQkPD39x8dHV2zZg0/P7+AgMD69euVlZX/1nu+dv0n+k1hlLwmLHra3M4oEe+ANdaOAj7+7xalSE5MTIiIiJAfKigowMnYyspKVlaW/PPx8fF79+7Nzc05OzujUCgLC4vs7Gz4FBcXF5FIFBERGR7+LUzs6OhoZGS0wo2dP3/eyMhIUVFRX1//UyawhYWFk5MT3PB5enq6u7t7e3svDr6tzN8KJrCHhwf47Ar7MXZQjY2NBAKBvEf+PloM388//8zBwQGnPXt7+wMHDsAt4KNHj8iv9/Pz27dvn4CAALQq3r9/z8PDEx0dLSgoCF/w9OlTLi6uxWvcN1dqUh8AofQKxzeZWwl7+PF6ooGe6em6hsWvGRsb4+DgePnyJXwoLCw8ODjo6uoKAAgJCUlKSoqKivrxxx8lJCRsbGzCw8M3b948NzfX0dGxbdu2iIgIRUVFWVnZV69ecXBwGBgYJCYmenp6btmypbW1deV7++WXX1AolLy8/McmCOTPzMzM2tra1dU1PDwchUJBz7OXlxc5+Abz/5Y1Qcj8fWwCe3t7u7q6gq9lrrm5uel3VVdXf+dsl66uLnFxcQRBnj17Br+vCII4Oztzc3OTmTt58mRubu67d++uX7/Ox8cXGBjIw8Nz9epVBEEuXbrEwcERExPDx8cHc7N//vlndnZ2shX8d0hOpgSw6jBqKHLYuUj4BrI7e6yzsv/5w1LU+/fvZ2dnk9PFsVjs1atXT58+7evr6+bm5uDgYG1tPTc3d+XKFRQKZWdn19PTA1+Jw+Hs7e39/f3v3r2LIEheXh7Zi9ve3v4lt/f69euEhAR5eXktLa2PTWAzMzMbGxsXF5ewsDBoorq6urq7u3t6esLgGzn/78tNYC8vLzQajcFgwJdj1/ShGhsb6+vrCQQC+fv6HTQxMbFx40YJCYmDBw9KSEjcv3+/uLgYAMDHx3fkyBE+Pr6IiIiOjo49e/YICAjs3r3b3t4eQZCgoCBOTk5RUdGdO3dGRkZevHhx3bp10NrdtWuXs7Pz33fDP117SL8GRcUvyCB7lM3AZI+DG4WBmUnymb/vL/454XA4JSUlDQ2NxSYwzD2xsbFxc3MLCwuDWMP+B4v5+0ITOCwsDDpfMjIyurq6iEQi+FrsGj9UVVXV98w2eP/+/dTUVF9f38TEBPzJL7/8MjY2NjQ01NfX19fXd+nSJQRB7t+/TyKR4GwHde3aNRKJRDYspqenSSRSX1/f3NxfCuoPDPxSW3vn/v1P7j3S0/rBWil6MQF6cSkG2aO0SsdpjiqPzf8T8zMGBwd1dHSgFxpuAc3MzCB8KBQqNDSU7IKBLRDc3d09PDy8vb0X558uuwWMjIwMDg6OjIw8c+ZMU1MTiUQqKSmJjY0FX7jCLsGu4XfV1NR0dHT8D0Z7379/Z27eDACeiekcN/dMVdXyHR1kFaLBbh56MTF6UQl6UQmwh9MiIOg73+qX68aNG/b29goKCnBLY2xsbG5ubmtr6+XlFRERsbgWDvLn5ubm4eGxOP95iQkSFRUVGhp66tQpHA43MjIyNDSEw+FiYmIyMjLm5ubA1051DYtUX19fX1+Px+Pv3Lnznx63T+rVq1dPnz5dWFi4efPm9evXL1++PD8/PzU1NT8/f+3atZ9//vn+/fu//vrr1162tXUcgMDVq9tkZeckJa+uWzft6Hj16dMPnNW3bt2nozej2HeY4bAIvagElYAgk7Do9VvfI5j7p/Xrr7+GhYUdPXpUV1cXToHQ4IBVulZWVuQoHJk/aIIsNoHJSQbx8fHV1dUTExPT09PNzc3JycnQcw5nK/CF2DV8qPpFqq6u7uzs/IcUebx+/fr+/fuXL18eGRnp6+vr6OhoaWmBbwFGpTs6OuCGo7e3l0gkwsqp7u7uwcHBubm5hYWFLywSzcjoAsB5y5YKXl6SjMy0svLV7dvnDh2a7e7+w9bOyekAQJuC0ZTukBy9uBjYzuV3KuvveuffVEVFRceOHTt58qSuri6c/8LDw93c3OAqvNgLDbeAKBQKbgGhJyUkJCQ5ObmmpmZqamp6eppAIKSkpKSmpvb29i52j4Cvwq7+Q9X9rsrKyr/VW7Gy6gaGomrqh0ZGe3t6Ghsbq6ura2pqmpqaenp6BgcHR0ZGJiYmzp8/PzMzMz8/Pz8/Pzc3d+HChdnZ2QsXLszNzcGHIyMjvb29XV1dcCP42bTFa9fuMjK6AYBmZcXs3t0mLDyqonJZSOjKhg1TwcE/vX37DkEQJ6dSAHQAsAMUNhSMOus2WT9YeP5dhuQbqKur68SJEzAX39TU1N/fPzo6GhoiH/MH81+cnZ29vb0zMjI6OztHR0fPnz/f1tZ25syZpKSkjo4O2P1sscCfmOrqPlRtbW1NTU1NTc13buD3+smTjv6zqlFxQN9sn4cvobGxo729r6/v3Llzo6Ojo6Oj4+Pj4+Pjw8PDAwMDfX193d3dnZ2dMCuW7Kdsb2/v6urq7e3t7++HmI6Ojvb09HR1dY2MjKy8nejtnePg8APAiYHhzNatdQcP9svJzR47dvWHHy7IyMxPTb1wckoBwAQAWwAsAVBPTmr7boPzTTQ/P29hYaGmpmZqaurm5pafn5+UlGRpaWlqampqamrxu6ytrZ2dnT08PFJTU7u6usbHxwcGBhoaGtLT0xMTE1tbWz/VUBT8uakOMkdWTU1NfX19a2vr3735e/v27U8//XR+dLSprk4/MJjW0Iza2mmPX/Dh8Nj2vr7z4+NDQ0MkEqmrq4tAINTW1lZVVZWVlRUVFeXk5KSmpp4+ffrUqVPR0dEw8hMTE3P69Om0tLScnJzi4mI8Hk8gEIhE4sDAwPDwMIlEgt/gFWbBhw+fmpvnAmADQNiGDaV793aKiY2rql7h51/YvDl71SpaZmY1ACyoqU3NzTP/GytgHj586O/vr66ubmdnFxMTg8FgSkpK8vLy4uPjYZFvUlISBoOpra1tb28fGxsjkUg4HC4pKSk+Pp5AIDx8+HCFi4M/N9Utxg6quroabqeefIvehkv09u3bW7duDQ4OEpqamqvxYckpe+ycKS0dtnoFCIVESoRF7/YODC4o6iIQcDgcFotNT0+PiYmBzURgOqSHh4efn19QUFBkZGRsbGxicnJCVlZIQoKHt7ejo6OFhYWzs3NYWFhqampBQQEOhyMQCH19fYODg3CynJmZWSGWU1p6duNGFABuTEyZ27Y18PENKSnd27cvGgBABYCmpsUvNx996nf/+Xrx4gUajVZSUrKzs4uOjsZgMHDRaGpq6uzshEtKe3t7Y2NjUVFRfHx8eno6kUhcHGf6lMCfm+oWYweFx+ObmpqIRGJfX983ND4ePHgwPDxcXV1dXl7e2dxUW1d3IjSC1sJutYvnwcAwibAY4eDIPd4BtHYuukGheUlJUSHB3p6evr6+p06dwmAwBAJhcHDw4sWLd+/eff78+R/GxOvXP1dX36mqevLw4Z2FhZ6enrS0NHd3dxMTE0dHx6ioqKysrNLSUviF7u3tbW9v7+7u/umnnz51nzduLKipJQFgQ0ERu3kzfs2a4xvWb2HduGmPrLxQYFDd1OS3GpD/iJ4/f+7n5ycrK2tiYhIWFpaWlpafn19cXFxZWYnFYlNTU6F7ubCwcGJi4svb+oCvneqWYFe9SFVVVW1tbXD6/Yvv9tWrV5cuXWprayspKS0rK+vp7BwbHAjPy99q70Jl7bjLN0gkNFo8NPoAOmSjqxejtSOTpt5RfUN5Q6M9Wro1Xd0rz773b97EcnK2AHB+w4Zr2trI7xGaFy9eDA0NxcXFwa1MUFBQdnY2Dodrb28/e/Zsf39/W1vb0NDQCktJSkorK6s/BYUHAIBtM+vmrVtV404rJaSye/jZFJUsPPkv7qX+8uVLLBYbEBBga2sLTRAXFxeYcJCbm0sgEK5fv/611wR/YoX9GDvYsK2qqqqkpIRIJLa0tPxp4+Phw4dnz56FXchramr6enoujI/XNDfLoIOAqc0Gd59DQRGSYTECQRE7vPzpLB0otPTp5I8xikutkpSmUlYHxzVDa+pXGsTXrwsFBcsBGOLiuqqnN7dhw9OcpS0Zb968mZuba2RkxMvLKy4ufuTIEVgDlp6e3t3d3dzcPDU19anvNw7XTkmxl5aWkYKKinEfF5+Hn0J4jGZCCpdf8KHQ6KbJqT83LP8cPXnyZGZmBgYqbt68+VcaN4KvXWGrPxR+kWpqanJzc2Fuemtr67KZjCvo4cOHvb29sAkmoaVl4OzZC5OTg/39jqdTmC3s6Oxc9qFDxcOiRUOi9vkGszp7gJN624zNcZ1dNsEhgJuXTlJ6lYIS0DHS1TNCPj3z1ZqaFgFwdseOaUXFOWnpWnr606qqy05mP/74o62tLRcXl4SEBC8vLy0tbUpKCvQOEonEoaGhZbc16uoqdHRg6w+bARs7pYLyJgNTTgdXCXTIyVNJspFxO7z8/apqX/zbaRNBEAQBXzjVrcAcnPNgq/yioqLk5OTW1lbY2/4LIwd3797t7u6GllRLS8vA2bMzE+Nn+/qiMrO4HF2pLO23evkLh0RJhMXwBoSxefhRmFhRqGnaxMX/srCAIMjQ6CglzyEgLQsUVTepaiQwMNz/RO/83vj4bAB6N26ckpe/cPRo76ZNHAAARsaTJ09+6t7GxsaCg4PXrVunrKycnJwME8F1dHROnz5NIBDIeaxQ8/PzEhISAADGVatySkpFLawBrwCzuuYOS7tDHr6qUaekQ6OAsZV8bOLLV//yh4CGhoaVLYnPMrdE4eHhGAymvb29o6Ojr69vZf/Cw4cPOzo6CgoKSkpKWlpbhwYGZibGid3dfknJ+4zNgOJxenObfT6B+/1DD/qHcfgEMtu7AnUtfnunjsFFrRTfvLYSEeXZtuPwzl1B9PRYAAY1NT/+W7MEQhoAHczMk4cPzyopje3cmQV+EwsLi6+vb01NzbI36efnx8nJiUKhVFRUGBgYduzYIS0tvXPnzvz8/KamJrJ3qaKigpaWdsOGDfb29mcHBhAEef78uXtcPOAXopCRZzOx2G1tz2JgymRpD4wtDTK+Wfvl/16BsrKy+vr6PzfVkYX7XXV1dTExMRERETgcDsa1JieXN/SeP3/e399fUFCAwWBaWlqGhwZnxsfb2ttdYk/t0jcGR5UoldRWHT/BbGyxzdWLyy9kg4cfjbEl80ndyMKiVx8lcTWGhVkC4AVAMAAZAFQzMDz/cP/7YHo6g4WliZp6TFj4gqrqCBdXFQADrq65GIyauvrGjRsBAMzMzB9X5Y2Ojm7cuPH69esLCwt+fn7r1q2zsrJKTU3l4uIKDAysqanB4XAwx93MzAyinJubu/gKzT29HOonaaXl6GXkGFTUmY3MWawdgbGVdznur356/+UCCQkJjY2Nf26qw32oyspKPB6fm5vr6OiYmppaXl4O+VtSIfHu3buJiQksFpufn9/Q0Dg42Dd9fqipuc06PPIHLT1wVIlKWZ1R7SSTqsaqI0cZT+iw2jjt9w7Y4ok+6Ok3f+XKsm/j9pUrFlRUDgB4AJAIQBEAt5v+OMfn8fPnIZKHGwCY4OKaVVUdFxJqAKBOSur170aDqakp5EZHRyc0NJTcj+vt27eCgoL5+fnw4ZUrVw4cOACz3Dg5OV1cXOBJAS0tLZaWluzs7Bs3blRQUFiyFiMIcn5+nkZAmFpQhP6wLKO6JrOxBZO1IzCxSmrt+Caf4n+pQEdHR3FxcW1t7Z+b6sjYkVVVVeXg4ODp6ZmZmYnH42Esi3yGzMWLFysrK3Nzc2tra4lE4uTkYGNjh44mdo2YPVBSoFHRYFQ7yaiqwah0nFFBmdkXZ/gAACAASURBVF5CmuGoIpOxxVYXTw7vgP1BEY8+XbIUr6ioB4AzAIEA5NDS/rro+Aat0AigoW2iazitrHxJVLSVlracje3J3T+6ki0sLCQmJmppaUEEAwMD4c+9vLzY2NgGBwdh/K2trU1GRubq1avW1tabNm3S0tKKiooqKyvz8PAAADAxMX2qHKRraAjwCtCJSNCLiDPIyDGe0GExtVpl7UhpYYc/9x+Lif/HBR48eJCfn0+G708zV1lZWVFRUVFRUVtbGxwcbGRkFBISkpeXV1tb29bW1tXVdeXKlaampszMzMrKyq6urv7+/vHx/rS0WlbWRAASqASsmbSOM6loMCqpMh5VYpA7BkQlwcFDFEJijCd111o77vcOWO3k4fbpperutWuRkpK21NQBW7dOlpeTf+6XlQNUNLa6eAhEx2v5BdVsYaukADfPnfv4CkQiEcK3b98+VVXV1NRUExMTaWlpKSkpcXFxUVHRnJwcWJp5+fLlffv2KSoquru7+/v7q6ioUFBQUFJSRkVFLXtvpzHFgJuHQVqOXlSCXkScQfYok6Yei5k1naXDKltn0j8yt/Q7CCAI0traWlZW9texg8Lj8RkZGXp6evb29jAaU1NTA4/0wGKxBAKht7eXRCL19rbn5lYwMSUCcIoCJNJud2fSOLbqqBKDrAIQEgM8/Hy6Brn4alUnVyAmxWxswebssc8ncIO7z5VfVuqjePvKlWeL/CxFzQSgpLbR3uVwYNjRkMg1nugdUkfmP6zjXywYl2RmZgYArFu3boVQdUdHh5qamomJydq1a5mYmLZv3+7v7/+p/plWwaHgIB+DtByDtBy9iAStsBiD/DEmbYPVFrbUFnZb3Lwv3V7+Dw0ODhIIBHJg/sWLFy0tLeQCDrKuXLlCzue9evVqR0cHdB69fv16cHAQlkn8p5pMrCCAIMjdu3fLy8v/InMVFRWw5rSysrKkpARujBwdHU+dOgXPrIHNK2C0vq6upry8gIsrEYAYKqpIKsoQSuoAGv4TQEQQ8ApImJgXNzS+ffMGQZDR6RlKfmF6dc011g77vPzXOHs4FJd/7k39pv6JCTp1TRZLe1F08LGw6L0oX3BCx6/k87+uqakJAKClpRUXFzc1Nf3UuXM5OTnKysq0tLQMDAysrKzp6el4PH5ycvLhw4dLXNBS5laAX5hBWo7hyFFGRVVqYTEKAeFVx1SYdI1WW9oBMxtudPDCh+kLb9++NTc35+TkFBYWFhAQuHXr1pMnT0RERPj5+Q8cOGBqakqOYRYUFOzatQt6tUpKSrZs2SIoKMjNzX3lypWJiYm1a9dKSUlJSUlxcHBERER84dB9HwH4D5FILCsr+yvMLVZVVZWLi0tgYGBYWFh+fj5Mte/r6yMSiQ0NjWVlJQUFSSoqEQCEU1IGU1D4A+ANgAOgsDpq4lnX1bnkFk+4ewAhMSYj8y3OqP2+QayuXtM3b372jd34+fYWfRN6YwsBn0DFsGge7wCgbagXfepLBuXFixcNDQ0qKipwFU5MTFz2Zfl5+cwszOvWrduyZcuJEyfOnDlTUFAAI8Ktra29vb2jo6OXLl6cu3iRXVGFUkySQVqWQUaeRvF4fFkF53F1wCfIqHScSc94tYUdMLY8EpvwfFHuQl5eHjc3N0TKzc3N1NQ0MTFRRkYGQZB3797x8PDAThqXL19etWrVnj17Xr58+eLFi507dzY1NSEIEhISYmhoSCQS5eTk4AUXFhbY2dn/Ys3Kt9Vv8F28eLGkpGQJdl/FXNnvgpNfeHh4QkJCVVUVXGf7+vpaWloqKyuzsjIiIoIPH/YCIAAAfwC8ALClpLTX1U3r61m+CnNybo5WSJTu+Mk1Vg6cXv6szp6m+ZiV31VDTy+3hTXQNd6N8lUIjRL2C6Y0NBd293r27CtyOfF4PIRPTExMWFgYU4hBEKRtqM0n28ch1SGpPmnb9m1MDEwsLCxycnKurq5oNDo1NRWLxcJgD1RLc3NqVjaNsDid1BEGaVlaGTlGVY0Hz55NXLjAKChCJSjCqKrBZG6z28OPzd3HDlPy7v17BEHevXsnLi5eWvrbCZSvXr06e/bs3NwcDFrev39/165dsFRKVFTUzs5OSUkJQZC+vj5yw5f5+Xlpaem6ujoBAQGYtZSeni4iIvK1Yae/Vb/B9/TpU0jbX8EOnlJZVFQE54C6urrOzs7+/v7Ozs7q6urCwsK4uBgvL18WFgcAfAHwAsCehcXVzq7g/PmrK9+lsX8gEBBhMjT7wQnF5Ru01tVr9OryDS7azw3LO7kCPgFwVGm1tcMaF092L39mS/vNplbXb9/+2tEZGRmpq6sDANDT0u/YtUPeSR7IACAHgAoAJwElJyU1JbUwv7C1lbWampqlpWVQUFBKSgqc/yorK6urq7va2wNi4wC/EIO0LIO0LOVh2V0mFi/fvEEQpKWnZ5WYFL2+Cbu7t3JMglZi6mZXr8nrPyEI8urVq4MHDy47S71//15CQsLR0RFBEEdHR1lZ2du3b0tISDx//hyDwaipqcGX3bt3T0FBoaKiYuvWrXJycjIyMjQ0NCgU6mtH4G8VIP+vs7MTDtmfYA5OeGVlZdnZ2WfOnCkpKVk84ZWWlsbExKBQKDTar6ioyMAgcfNmrx9+cHNwyLx58/4KN0fW7OUrdMJidKoaq63s93qiN7h6aaZnL3kNaWJS2d0TCIkCAWE6UYlVCsosZtZrnFCrXL1YrR1Jk3/+TD0pSSkKQAH2AiAJ6NTp1umu22+xX8hRaJ/tPiALcgg5z54+Cw4OVldX19LScnJyCgsLS0xMTEtLy83NxVdU6Dg6/7bhk5YF0nKCNvYXL8wiCDI8e4FJ32SjM+poZJxeUppQYDitmc3YlR+R32e+xREXWCr6/v17RUVFeXl5BEGuXbu2bt06QUFBSUlJdnZ2UVFRFxcXsq9nfn5eSkqqqqrq2LFj8CeXL18+ePDgP6qx5x/wXbhwAYvFfi1zZWVl8CRqDAaTmpqanZ0N64n6+/u7u7vr6uoyMzMjIiIyMjJMTEwcHZ0SEhLw+NKqKnxzc/PQUM/Vq1+a/GIfEQX4hZkMzDY7unP7BrE4ewxc/s3hPHphTtMHTSEiAQ4J0R0+wnDkKL2YBMMReTozawqUH0D5SpxK+itj9OL5Cxe0C+ACdAp0jOqM7PrsYvZiqj6qx7yOsVmw7bDb8ezVMwRBxsfHY2JiLC0tdXR0dHR0jI2NbW1t/X19+dQ0KEQkoKkLZOTVvH0nSH0lVVXrjC1W2zofCY/RT06XCo0GhuYqYZFkMyItLY2fn//Bgwdv3751dXVVVVV98+aNhoaGlJQUrNJ/9+7drVu3rl271tvby8fHNz4+fvv27QMHDhAIhDdv3vj7+2tra/f29h4+fPjdu3fv3r27efPmtm3b/lHnqfwB36NHj+AE9oXYlZaWlpaWwl/Jzc1NSUkpKipqbGzs6ekhkUgtLS0VFRUpKSkJCQkwwjY+Pm5jY+Pg4BATE4PFFjU01MEO98PDw1/S8+DazZuMYpK0ymqrLe04PPx+QPlpZuVPXLxkFBxKI3EYHBKkk5JhkJFnkJFnOHKUXlyK8oj8TnVNQ1kFXQUVbpTP7Rd/qa2Cnoce4AR0cnSsaqwcBhziduKKHorHPI5xW3MDVUAYIZBf+euvv87Pz3d1dVVUVKQkJ/v5+m6QPEwtIc0gLccgI0evoMxm76IcHs1mZEZvaS8ZGqWfnC4bEUdn5cDl7H73/h+emrdv39ra2u7atWvv3r3c3Ny3b98ODg4GAHBxcfHw8OzYsYMcxLt79+7hw4dhalNFRcXu3bu5ubk5ODjm5+dnZ2dZWFi4uLi4uLi2b9/u6en5VwbhmwssftDa2gobh32WOajy8vKSkpK0tLS0tLSKigpo4sEJr6CgICIiwsTEBH7V3r59e+/evfz8fOj/i4iIyM3NhfEPAoHQ1dUFe/ysLLfYU4BPkMnAdLOzByfKl1lTl0FaFhwSpJX8HTsZeQYZeSrxw4CHf+c+rmwa2hEArgBQzbru8u+txL5Ez549g26zwsJCS0vL6alpeXN5sA/QH6bfpLJpv95+fnN+IWshXitedmN2oAgqiZWfutSDR4/WHZGnEpdikJZlOCLPqKK+w9GdWsdwlYWdcFC4XlLasahTq51QP9g6Xnu0TKXI0NBQa2srrPu6dOlSb29vR0cHHDRy8uabN28Wp1jfunWLSCTCupN3794NDQ21tLS0trbOf80IfB99AN/58+eLioo+yxyZvIKCgpSUFBgrg0WHra2tlZWVKSkpsDGllpZWdXX12NhYVVUVFosNCgrS1taGZ2AGBgZmZGRUVFQQCITOzs6Wlpbx8fGVG/7dWVhYKy1Lo6zGYmTOKKtAKy5FKynNICP3B3YShwE37wbZo6jkVLddu84AQKCgGKKlHQXgF8xnDOSnT5/CRvsNDQ1bt249ceJEX18ftHYVZBXULdXBXkArSrtWfu0OjR17dPZs09m2Xns9oyYjxTGKztGl7iGynj1/vuWYMhAUZZCRpZdVoNfQW61nymxpx+cfonP6jEpMwkYPP0YDM9yBg3d0dX9OS3s6Pf2pS/3/0wfw3b59G4vFroxdSUkJXG0zMzOTk5OLi4ubm5t7enp6enoaGhowGEx0dHRoaCjM8c/KyiooKMjNzYXnVNvY2Ghra7u5uYWEhOjp6Xl7e6ekpJSUlDQ1NXV3d8Mo3LVr11ZovuGblAL4BFfJHaP/EDsaSWlwgJdFXMolKubmnTsIgiQcOxYEQAMAA7S0gwBc8fL6+GqvX78uKipqb29//fq1kJAQDQ2Nj4+PvLw8ZO7UqVPbt28HAOhq69Z11AF2QC1ITS9Ov1puNasSK7MqM/1xegpFii0nt6w8xLnVtRSHhMBBfippRTZddXozuz1eIdqJqepxSdu8/KktbLMkJBcOcM+ysU0yMY2vWTOvrPzq6w3z/0Z9AN/Lly9hKvyyzEHBh2fOnElJSamoqGhra4ONAfB4fGZmZkhISEJCQnFxcUlJCRaLLSkpwWAwGAymtLQ0OTkZNoFTV1dvb2+vq6vT0dFxcHA4depUQUFBdXV1W1sbrIMaGBi4e3f5GNrd+/c3yh+jEpMiY0crJQMO8tELi9uEhF1elEZV5O6OAgAPAImSchCAOVXV5y9evHz1CkGQnJycY8eONTY2hoaGAgDWr1+fkZFBQ0MDAODg4MjOzmZlZeXm5r579+7MzExhYSEMmqnYqAA2QCNITStCSytJSydHR3OEhuowFf0Wej9vv0/dMNTozKxfSr6+JXd9zpryimPWaYnHYtL3+gZS2jh57d03zcJybufOyQMHZgUF5wUEplhYfrSx+Qaf7T9eYMnjjo6OoqKij5mDKisrw2AwSUlJGRkZeDweVs4RCITS0tKEhITg4OD09PTS0lIsFov5XUVFRUVFRWVlZT4+PvAcEm1t7StXriAIMjIy4uzsrK+vHxAQkJaWVlpa2tzcTCKRenp6Ojo6zp07d/PmzY8L4aLzCsBeLprDR2gkZQDPIWoBYRO0//TFS0vfSH6+PQB4AEbY2a9ycDStW7eHk1NCSopIJNLR0VFQUHBxcampqcFJrqys7PTp07y8vHAXf+/evY8LJX/99VdTT1MKTkAjCKiFAOUOwLiOiWkDEyWgpKKi0tPTW7lb0sVxTH0m/UTz/mezRrcmHOTDfYC+leiWrfkAFAFQRUHRTEvbvXr1ABvb8A8/nFvUMvr/sZbCNz4+np+fX/KRiouLS0tLCwoKEhMTc3Jy6urquru7e3p6GhsbCwsLyZVz5KmuaJEwGEx+fr6FhYW+vr6mpqa3tzc5vfnp06dZWVm6urr29vZxcXFwCuzo6CCRSCQSqbu7u7e3d3Z29s6dO+Tt4Lv3742DQmhFJRhEJXQ8vEamlt8kzQ4MuABQxcBw/vDhZ/r6vWvXsgJAQUMTHh6urq4OADhy5MiNGzecnZ1DQ0O/sNovID8fiMhSbFBj2qFPRb2KbdNGts1sAABqampqamoZGZmPM/l+G9WhsqJ4ynP1e26OmSzMON8+K+ofvcc0IavI0tKAgcEJADQAMQBkAFAKQDEAZy0svujT+y/XUvhu3rwJk9rJzEFBB3JiYmJRURFsg9Ld3V1bW5uTkxMeHp6UlATX2aIPVVhYCImMi4uDvfePHz9OjhqRNTo66unpqa+v7+Pjk5KSgsVi6+vre3t7R0ZGhoeHYQuVnp6ec+fOXbhw4datW8+ePh2bnp5f0V/66N49D1ra9FWr+vj4UNu2CbKwrGNhYWJi6unpefr0KR6P/9qGvrfv3GFWV6bgMgcgcfvWcxs36FBT06xbty48PPzQoUMwEUFdXf1jR9qFqdbCU3Rnq7fdGNa/N+t6se9oUy5FY7k+fLaqrk5HRcXqyBE3Hh7XNWu8GRnjhIV7Ozu/vPr1v1dgSSH0ixcvoMe4eJFKS0vT09MTEhJggU9fX19nZycej09LSwsLC8vMzCwpKfmYObKKi4tRKBRsuaWlpbWszf/69euamhpLS0sTE5Pg4GB4TRigGxwcPH/+/Pnz50dGRkgkEiweOzc4ODo8PDw8PDU1deXKlTt37jx9+nRJvUiuoaEzAMG0tACA9Tt3bty0iZ6ePjo6WlZWVkhI6NxyKX0riNDbC2TkKJgtAUAxM6esX99KQSHNxEQtJyeXmZm5adMmyB8nJ+fiRKxrV0YK49f2Vm66NqR9/4LblX6V1kK62iK5Vy//iDL3DQxYOTl5oNEJp04V5Oa2EYltXV3T09MvX7589uzZo0ePnj179t/YauOzAn19fUuy0AgEQkFBQXFxMRaLhaZDampqUlJSRUVFe3s7iURqbW0tLy9PTEyMiIjIy8srLi5elrnCwkKYZZ6VlWVqagrJ8/DwWGEc7969m5GRAdOxfHx8Tp8+DZtXNDc3wy5m4+Pjs7Ozs7OzMzMzk5OTY2NjMM24u7u7u7u7r69veHh4Zmbm9u3br169evPqVbWfnyQ1NTU1NQ0tLQBg69atmzdvhvs8IyOj2NhYSUnJ2traLxmpkLxMsF8BAHsAXAFAARAJwG4aGkBJSTk4OPjkyZMDBw7AJfjgwYNNTY0Igtz+eb7oNFtX6dofBzTuX3C7Oniis5ipKof/16d/1Fy+evXq8ePH+fn5urq63r6+GdnZ0P1ZX18PG7pBO4xEIsG3dv369fv37z9//vz/QUNOMDw8PDg4uNjBNj4+npubC8krLi5OSkpKSUnB4XAwaNba2gp7msbExMAa22WZI6u4uDgiIkJXVxeuuZjP+dsQBLlz5w4ej/fy8jI2Nra3tw8ODk5KSsrLyystLa2pqWlubu7o6Ojt7R0cHBwbG5uampqdnYVtzqanp0dHR8+ePdvT09Pb23vlxx9be3qgPUtFRQUAYGVlpaGhoaKiYmdnT0lJAQBQUlIeOnSoqqrq8OHDCQkJK9yVoqcbWHsSACcA3ABwA8BpK7uLmJgIAMDFxeXVq1cTExOqqqqwEGnHjt34qpLqPIG2IsbLJJX7s67Xz2n34TbU5O178vgOgiD379+fm5sjkUiw6cng4CCMQPr5+cFk79ra2paWlsHBwYGBARKJ1N/fD3PSurq6YH/B/v7+8fHxf1SWytcKtLS0DA8Pj42Nkb9Js7OzcD7DYDAwQF5dXQ2/fAQCAYvFxsTEJCQkwB3ep5grKCjIz8/Pz88vKipydnaG571qamp+eT7t27dvR0dHs7Oz0Wg0PBvY1dU1KCgoNjY2NTU1JycHg8GUl5dXV1c3Nja2tbXBbnzj4+PT09Nzc3Ozs7OTk5OdnZ38/Pzr168PDw+PiYnZunUrAGDz5s3KysrXrl0TEhICAJiamu7cuRMAwMjISCQS/fz8oqKilkT8Hj99vEVJC1CYA+AKgDsArgA4HdLMCDwVDgmOjY2F97x//34AAA0NLT0DS5Ar060RhXuzLj+NGAzVshcnsZ4lNY9PzLS1tTU2NsKAEBx8uLV1d3e3traOiooqKiqCNdRwVSF/8aBDHqaCQ8HJ/tatW/+N6zJIS0uDe/np6enp6enGxkYMBgPBiouLy8jIgJU+fX19TU1NhYWFUVFR0CZYmTkyeWfOnDEyMjI0NNTW1nZ1df0TPYTev39/48aNzs7OrKys8PBwDw8PBwcHeESJi4uLn59fRETE6dOns7KyioqKYBFJa2trf3//xMTEjz/+ODMzY2hoaGVlNTk5SSQS6enp4bK7efPmhIQE6PQxNDQEAAgLC2tra8NnS0tLe3t7MzMzYVnk2OVZsFsOAEcA3ABwB8AZUHpt0nT0tLOEr8/5vefGw4cPjYyMAKAEYFWAK/ebn9x+HjcdadxdmsKYnR7cTOjp6ekZGhqCwMGYEB6Pz8/PT0xMdHV1NTc39/HxSU9Px+FwtbW1zs7OmpqaxsbGDg4O3t7eoaGhsA1UYWEhrHklkUiDg4OwodaNGzf+If1hv1DA29u7oqIC5tvl5OTk5eVB8mJjY9PT0+vq6np7e3t7exsaGnJzcyMjI2EpxsrMQcFLBQUF6ejoGBkZqampLSlo/XN68eLFnTt3zp8/397ejsViExMT0Wi0k5MTPDTMzc0NLtNws9jf3x8eHg5NAT09vWvXrpWWlkL3HjMz87Zt29LS0h49evT+/fu2traFhYWIiAgIk5OTEy0tLQAAjUY/ffrUwd8X7OGloHMEwAcAFAAowOaruGfXVbRfcW0tLS2toKAgkUiEd/jLL3f4D65WPExHqpG/fk5vgsBdeYYOmxfQ1z85NjZ29uzZ9vb22tpaDAaTnJwcGBhoY2OjoaEBzyk1NDR0c3OLj4/HYrENDQ0mJiZ79uzh4+MTEBAQExODXWO0tLTMzMzgwUAZGRk1NTVwE9LX1zcwMPDjjz9+z8Mp/oqAkZFRbm4u9MzBOa+wsBD2C6+rq4PnC9TV1WVlZUVGRmZmZmKx2JWxy/td8KGdnZ2+vr6hoeGJEyfOn//zSXUr6N27d/fu3Zuenm5pacnJyfHz84PtMn19fTMzM+3t7QEAVFRU5ubm169fv3nz5oULF44cOcLAwAA5Mzc3J08Yb968yc7Obm5ubmhogM9qa2vLy8uvoqdft2c7jaASYDAGlHZgvfOxLXz5AEwoKNQ3N5PhJt9SYrhktCcVPmsfoWhLRSo1rthvdPzS8PBwS0tLdnZ2aGiok5OTjo6OnJyckJAQHx8fLy/voUOH+Pj4NDU1XV1dY2JiCgoKGhoa/P39ubi4BAQE+Pn5eXl5eXh4Dh48ePDgQR4eHgEBASUlJSsrq8DAwLS0tKqqKiKRODg4COdCePrrP1xAUlIyNDQU+kogWLGxsYvJq6+vz8rKioqKys7OxmAwn2UOCsZzExMT4aEiOjo6jo6Of6Wj0Zfr3bt3sDo4ODjY0tLS0dFRWVmZg4MjKioKNtubnp6+desWBoOBeNHQ0Ozfv7+j44P67ffv3yckJKBQqJnz51mZGFmZmZnWslJuY1u9hmnt9j0bxMScaShiAGhiZp5sa+Pi5aWkoNDU1Hz+u93246VzLuYb3MxBqBt9JdZrYvJSb28fDocLDQ1VV1eXkpKCZUECAgKCgoJCv4ufn19ZWdnJySk0NBSma5w6dYqHhwceEwcR5Ofnh5jy8vJyc3Pz8/MrKCiYmZmh0WgY8CQSiZOTkwMDA5/yeP9zBHh4eMzNzaFfraCgYMmcB8mLjY3Ny8srKipadm1dwhxZRUVFvr6+enp6xsbGampq5PMgv6cuX75cVlYmLi6+atWq7du3e3h4YLHY6upqIpE4NTWVnp4uLS0NTY0DBw4s63O5sXCPU0ERMDJRc3JRMDJtXLN63cb1bOvXb6Sh2b5xYzAAyPDw1Tt36BkZASOjuZ0d/K2xscmiwlxsYWJrS+3Q8HkCgZCenm5paSklJSUmJiYhISEhIQFrgUVERBbDJy8v7+DgEBwcnJ2djcfjk5KSIHACv4vMHxQPDw83NzcvL6+srKyxsbGPj09qampbW9v58+cHBwf/UXnLHwscOHDg6NGj4eHhRUVFMTEx6enp9fX1H5NXWFj4hczl5ubm5OTk5uZmZ2dbWVnBme/EiRN/vWPkn5aCggKc5OTl5R0dHWEMuqKiYmxsrLu7e+fOnRQUFBQUFHR0dOnp6eTfmrt+wyUnf62F3Rp7V6ajSnQycrT7uSkZVlEzMa8HgIqRkX7LlsMAmAoJ8YuLM9HT2zEz5zAy/uzn11JTcyY7e2BgaGp6vo80UFpaikajVVRUJCQkpKWlZWRkDh8+LCUlReZPWFiYDJ+srKy9vX1oaGhOTg755NKP4VvMHx8fHw8PDxcX14EDB44cOWJvb5+QkNDU1DQ5OTk0NPQPTOMjC/Dy8vLx8VlaWkZGRqanp9fU1PT09CwmDy6gX8gcWXD51tfXNzY21tPTs7W1/Y+cTA41Njamr6/v5eX1008/YbFYJycnExMTb2/v5ORkPB7f1dVlYmICAKCjo2NkZNTV1mruI9nnY5hMrIChObuzhzA65JAziklall5aFvALSxmauO7bRwXAehoa/UOHAACrN20yYWBoB2CMhWUMgBYODkJPz+DQUENDw+nTp42NjWVkZI4cOSInJycrKysjIyMtLX348GFJSUkJCQkxMTEyf/z8/IcPH7a1tYVNUSsqKvLy8sTFxRfD9zF/fHx8cBU+ePDgvn37REVFraysYmJiampqYDP+qampf6YVDPj4+Pbu3WtiYpKZmQnXo97e3sXkFRQU5H2kFbDLycnJzs4uKChAoVBwzdXQ0EhJSfnPvs+MjAwxMbFTp04hCPL48eOGhgYUCmVsbOzu7p6RkVFaWmpubLzjhx9oqKnXr2YBbOxAXWuHu4+gT6AUOljU25/b3YfVwBQcEqQREj17Ye79r79O9PTcvHBh4cGDnRwclAC4AVAEQDsd3cimTZMAnI2Obh0a8vf3YfSt5gAAIABJREFUh4eRKigoHD16VF5eXk5O7siRI5A/KSkpSUlJeGA4XHwFBASkpKRsbGwCAwMzMzPLy8vz8vIkJCQOHTokKCj4Jfzx8PDs379fQEDAxMQkPDy8oqJiZGRkbGxsbGzsH2gCg3379mlqakLyYBZJQ0NDdnb2suR9ljmo3NzctLQ0c3NzeH6XhoYGrHD+T+np06fU1NQUFBQ0NDRXfu9z9fLly+7ubn9/f3tr64igoOTCIn49Q0BBQQEAAx0d+5YtBwxNxUKj9rl6rjO3AUpqlPJK6l4+Q1NL+9o+fPRo6OxZjw0bggGoAKCHkXGclnZkz564+HgFJSXyyfVk/mRlZSF/SxZfERERAQEBaWlpOzs7uOyWl5fDYlt+fn5BQcFl+Vu8+C7mj4eHR1dXNygoCIvFwlDQ+Pj4P80RDVRUVGA7KZgHD8mLiYnJyckhr7NfyBxUVlZWfn5+eHi4vr6+iYmJgYGBlZXVp44B+T569+6dhYUFKyurgYHBx89Gp6Wza+rSGVuw2LvusXdh3cfFQAHWr169as3ajSLi9Cd1mTW0DINC+oZXaidVHxPjDEANJeUIG9sUG9scAGHc3NInTqgoKyspKSkqKpL5g4vvkSNHFi++kD8BAQEZGRl7e/uwsLDPwrcsf7y8vJA/Li4ubm5uDQ0NX1/f/Pz84eHh4eHhxcdw/hMEEhMTq6qqurq6SCRSY2Njbm5uQkICBOhrmSMrNzfXxcXFwMDAxMTk5MmTn2o38Z2VmJjo7e29uFlg3/SM1qnE1daOzLbOe9y8hX0CpcOi+Rzd6HftAVRULIyr2Das38bDdzoz8+3nNqz9XV3uAOAA6P/hh5n9+2fXru1jYNBUVDympqa8iD/y4rvs5k9ISAgaHOHh4bm5uZWVlampqZA5wd9FdrVAO/fgwYNwzls8+UH+uLm5OTk5lZWV/f398Xj81NTU4ODgZ4/1+p4CWCy2ra2NRCI1NTXl5eWlpaUNDg7CVJSvZS4rKyszMzMnJycpKcnExMTY2NjExOTEiRMkEuk//TaR+fl5WlpaCgoKFUVFBEH6Zy+ciImnNjCjMbHa7eYt7Bso5Rck7IXe6+jOamFLpW9Kd4CHCgAAwBompoNcXJWVlffu3fvUsnVnYSHU29sRgDQAWunpxzk4pnfuugjokn/Yc0RDU0VFhczfyps/ISEhRUVFJyeniIiInJycysrK2NhYyBAHBwcHB8fevXu5uLh4eXmFhYXl5ORUVVWlpKR4eXk5OTl37ty5c+fOXbt2cXBwwGUXzn/79u0zMDBISEjo6uqampoikUj/QctviUBjYyNMhcdisVFRUQ0NDRcuXOjo6IC+ki9njqy8vLzg4GC45hoaGlpYWKx8BtISLSwsLM42vXHjRnV1NYIgFRUVbm5ueXl5iwkYGxsbGBggP2xvb4eJCw8ePIiKivL09PTw8MjKynr69OmlS5egt+UHzn3qcYkMJpa0JlZ73LxFfAOl/IKEPNEcTu6rTSyBgspaDS0JY1M1HV0Lc/Nt27ZRU1OvWrVKUFAwICBgfHx82RRUfHV1QkoK+tAhNACVFBT9Gzed5+KcPLZpRJbeSFlOQVVdRUVlyeK77OZPREREQ0PD3d09JiYmKyurpKTEzc1NXl7e09MzKioKZrt0d3ePj49fvnz53r17z549g4Um3d3dxcXFiYmJHh4exsbG0tLS27dv3717N7R/hYWFXVxc8vPzR0dHYUD5T4Dydwj09va2tbXhcLigoCBPT8+GhoaJiYmZmZlz586lpKQswW4F5sjKyclxdnaGa66mpmZ8fPxX3dC9e/f27t2blpYGH4qIiISHh2dnZ2/bts3V1ZWXlzcgIAA+9euvv7Kzs/v5+SEI8uLFi4SEBABAZmYmgiCtra2srKxeXl7u7u6SkpJaWlrv378nkUiqx48Dbh5gZsPm7iPsE3jYL0jIE73HyX21sSU4qsykdNwhJu7y9evI61d4HA4m42zZsoWSkpKWlpaFhSU0NHRycnJJi/03b97ExcVV1ddXZWTYAZAOQBsdwxjH7nOh7BczmPNd2OUUTy6e/D61+YPw6erqenp6JiQk5OTkZGVl1dXVrVyatKwePHhQXl6ura29e/fubdu27d69W0lJKSgoqKamZn5+vr6+nkAgIAjy7NmzhYUFBEFevnx58+ZNBEEeP37c09Nz88MmYC9fvlySuPXkyRMYvnv9+vXExER/fz+JRIKX+iqBzs7Ompqa+Ph42O8Ih8NNTk4ODw+/efMGh8OdOXPmC5mDys7OTk5ONjMzI6+55HD7l2tqamrLli2jo6MBAQFSUlIIgsjIyHR3dyMIMj8/z8bGBjcujo6OsMARQZBLly6pq6vz8/ND+BoaGmDjJqi9e/cuLCxcunSJbcsWtvXr18jIsaNDOXwC9zi6sRhbgKPKLErHHWPiLn4YD5icnPTy8nJxcREWFobR4TVr1igrKw8ODi4+vXNmZiY4OLi9o2Nkagp96JA/ADhA0c+6iWS3cSx+8/loOisd6aNKJ5bwt2TzJyEhISQkJCMjA7Nok5OTc3Nz09PTb35BM7gVdPbsWXd3dx4eHjY2Nj09vdOnT4+Ojp4+fVpQUPCXX35JS0uDZ0BUVlbq6upevnz5wIEDIv9H3HWHNZVm7y+hJPSmFBVQUBFpUhMISeihQ4CEQEIglEACCSWQ0HvvIEiRptKVoqAgimIXQQF7G3XUdUZnZ0cdnZnVUX5/3JFlERVndvf3Pjw8RG+Sm3vfnPOd853zHhRKS0trsUwMmUyOiopaePj+/XtLS8vs7Oz5D19yW1tbHA63ZcuWjxskPg8AFQ3Y2tpqaGgEBQXt2bNndnb27Nmzb968efbsWU1NTX19/Rc5t9jnQspwgYGBNBotKCjoT3wh5ufn+/r6lJSUdHR0oJL0hVprHo9HJBLn5+f37dtnaWkZGhoKXQUIwcHBUEHo2NiYnp5eV1fXnj17/Pz8bGxs3r9/D23mKkpKSmjrqKfmKCemA5K/vLNbVFHJnU+EgS9evKitrfX39ycQCBISEtLS0hISEkQisbGxcUExsqenp7y8/Ny5c+cuXUoODQ0HoA6AI0KS4z7SpwtX3S6V7eSp2Dt7ubi6Qvxb4nzxeLyZmZm9vX1ZWVltbW1gYCC0Swv5nE+vWL6ijPnhw4dlZWUODg4hISG9vb27du3S1dUdGhqytrbesGEDdFWTk5OJRGJiYuL8/Pzhw4e1tLSgBEVnZycAYLG8VWZmJgAAEgBub2/H4XDQv58+fVpdXX0lyhMLAO3t7d7e3lpaWtra2jQaraur68qVKydOnIAu7tmzZ6FSuZUwD/K5XC6XRqMFBgZCyu4rP5UlcHR0hKzaAvr6+uTk5B49evTNN9+Ii4uXl5ez2WwajTY1NQW121CpVCiyPn78uJKSEjSzauPGjWQy+ffff3/x4oWhJRbIK0hRg9an5YhzeC75xQ8/PctvAcPDwxwOB4vFQoUwSCRSXV29o6Pj5cuX7969Kygo6O7uvnjx4tDwMJXBCJCVzQKgDwgfQiMPZ4nNFKy9VoiI9MfYO3m5uro6O7s4OjkTHJ3sHZxs7AiWOBuCm0duWdn1Bw/m5+crmpupLFZKcXFRfX1hXV3XIkH9BXz33YvQ0NOmppORkff/8Y+vKNR4+PBhXFycQCDYu3evsbFxfX29lpaWtLT0vXv3nJychoaGTp8+DRHuwIEDurq6//znPx8+fKitre3k5BQdHQ29yOjoqI6ODolESk9Pn5+f7+7uNjc3//7777///vve3l5DQ8NPqbguCxAWFgYFUFu3bo2IiBgYGLh+/fro6Chkcn7//ffOzs7q6uoVMq+yspLBYEDDgIlE4qfGqqwENBpt+/btCw8HBgZkZWUh5zs4OAjtwWtqampoaBAIBMg0LpBveHjY3t5+4bmGhoZQbtmZGQFk5BT1DNZFxsBY0fXHVrokOHv2bERERHh4uIqKChwOFxISWrNmDZPJPHLkSHFx8fixY5fm5rbX17v6+3tZWbEArFYV7GMI98bAzmSuul2qMJioaOvkY+fk5eDkQXB0dXR0dHa0c3eySYgJPjXQ9fLSpVeTk98ODuba2hZZW+90cNhNIOy2shp1dr4aFHQ/MfGfHzqSfv/9LQbTCED7hg0zSkrXKZS7X9XJ8cMPP4SHhzc2NtrZ2fn6+lpYWFhYWMTHx1taWi5YrOvXr8vIyIyOjr59+9bS0rKgoKC+vp5Op799+/Zvf/vb2rVrR0dHs7OzY2Ji3r59OzQ0JC0tDWUcAQAFBQUrP5n5+XmAxWIh8unr68fHxx86dOjmzZv79u1bqHd/+PBhVVVVXV3dF8nX1NSUmZkJmT06ne7n5wepZ/45+Pj4LDRV9PX1SUhI9PX1vXv3bnG+Gpq5sPCQTCYXFxfPz88PDQ1ZWFi8evXq5cuXBw4c2LBhA7Rk3mZqKgyAmoy0gr2jcLSg4/TZlZ/P7du34+Pjvb29zczM4HC4rKysvLy8LYGQU1ExefHiiePHk6OjqQQC09GZLye5nQT2pcB6OeBIkuj5bNmzGSK1LJWaiHXNUUrtXIWeWOmBeMlDidJnypTOOyocB6LjcPg4DHYWgTgvJnYegTiHRJ4XFz+NQJyVlb2urn7Lyurtixfz8/O3bj0CIF5SssvMbBKNvr5q1fnHj79Ca3V+fr67uzsjIyMsLAyJRHp5eSUkJCAQiIX18aNHj1RUVKAYcWhoCA6HYzAYLS0tVVVVV1dXOp0uISGBx+OhOMbX17e5uRmLxT579uzZs2ejo6Pbtm377muEPkBvby+UEDIxMcnIyBgfH79x40Z7e/vigPzw4cOVlZVfJF9jYyOXy4XmYfr5+fF4vL/SfBoeHt7c3Dw/P//jjz9qamqqqKhYWVkZGhqampouZOqhgeELT2Gz2Q0NDfPz81NTU2vXrjU2NjY0NNTW1m5vb5+fn//t7dv1GCxMRERETl4ljC3C4R2c+boxuN999x2fz+fz+Wg0WlhYGAAgg0SmKSqeNzQ8pap6VETkpJDQeRhsSgg2JQeb4sCmi2FTObCpHDCZjZjKWTWdu2o6V2kqd81UruqF3PWTuRrnijXPum08q7r5rJbWWW3tszo6Z3V1z+jpndHXP21gcEpffxKNvufjc1FG5vu+vvn5+ZmZ+wBEy8k16egcVVU9Kyk58eDB15HvwYMH0NxrISEhPp/f2NgoJCREo9Hm5+cfP368devWmpoa6Mhff/311q1b165di46OJhKJN2/efPz48e3bt69evQrd4rt37+7evRtSqpyfn3/48KGSktI3n5jSsyxAS0tLW1vbhg0bzM3Ni4uLT506BQmUDA8PLxwE6QrU1tZ+nnmQzw0KCgoMDPTy8tr50SjRr8Lr16+hpNq7d++ePHny8OHDO3fu3Llz55tvvlmo0Xjz5s3iwPPtoiTc48ePoeMXMnPfP3u22sNbxMFZYpuRkn+gVHTCxW++utzt73//e0pKCpPJjE9IkJSTowoLHwHgspbWQxzumoTELAw2Kyw8IyJyCYhc0ha5WCJ6MU90OldkKgd5JtfgVK7ZqVzTk7mmJ3LMJnLMjmebHSs0O0o2OqJtMGZgcFhff1RP75Cu7kEdnSFt7f1btgxs3rx/8+bj69YdAOBvIyPz8/Nzcw8AiJWTa9bRGVdVPSctfeLevZ9fvPjp7t27MzMzV65cuXXrFtTId+/evfv373/zzTfffvvtkydPnj17tlDJm5+fn5KSoqysDI2nV1FRiY6Onp6eNjAwAAAEBAR4e3t7e3svbAUVFBQEBAQsvghcLhdyOPv37xcXF/fx8fHy8lJVVYUWgisHiIyMPHfuXGFhoZmZWU1NzeTk5NzcHNQutXg9cenSpYqKis+QD8otBwQEQOTz8fGZmpr62lv7F/Hm99+Hpy+Nzl15+csy9uCbBw+kXTyA8hpFSQllRUUZP/r9P1Vr/uLFi5SUlKiYGIavbwwAPXJy0zjcHWfni4qKpwE4LSR0Cg4/AeATCvBjqbBjqbAjSeBgAtgbp7mXp72Xt6k7RqOTq74nSrWNvaaZs3qnlXw9UrpWUnK7mFglAlEmLFwMg2UBkA5AMgBJAGQBMODk9Oa33+bn52/ceAJArJxci47OMTW18xISx3btGjl69CA0cf7kyZMnTpyAmuqhRuZjH3DixImzZ8/Ozc09e/ass7OTx+NVVVVNT08fPHgwNzcXavUqLy/v7e1taGioq6urq6tbyC/eu3dvSf/DjRs3oAXVy5cvOzs7oeMXZ/tXCBAXF8fn8+/du5ebm1tVVTUzMzM9PQ3tqi3Opr579667u/szkQeUW6bT6UFBQVQqlclkfn7c938cf/v+qSGbA3zpwuGcTSmZYW3tQzOzL16/Xjhgcm5OyN4JrqgkAYeJiIoqB4U9+xpx+sV4+fJlclpacGBgpLBwsYhIv5raETm5gzBYHwC9AHQB0A5A6ybQyAbbA0EtA348fe1Ysny2DzzRDZboBhJcQJwTiHUCPC8kB4WMFEZwJCWjZGSiVq3irFvH1dCo8fbeSafvYbM74uJOtLdDJuufv/06MHAMgFh5+VZd3WPr1p1fvfr4yMjpS5cunDt3bmJiApr0eezYsePHj09MTEDNy1Bd8JkzZy5cuHD+/PkLFy709/dHRkYODAzMzs5CyhM9PT3t7e3j459UGfwvAfD5fA6HU1lZCW2mzc3NnTlzBtL1XpKzefToUXV19bKRx2KfGxQURCKRlmRJ/gfgV1QBC7xMOGdVrECCGw/CIuHhHM3kjNC29v0XZ1799tuREycBzkaKGiSJshC2wOln5f/zL/SUvHj+PCE1levqGiMkxAcgF4BUAHhCQlHi4mEy0oy1CqEECY4HSPEAHZHCF/KU5wrl90XD2yJgnZHwzkh4B1uom4scSlPrTVrTHbSqX3H1gJLy/nXrDqirD2toXMRi52xsrtjZXbWzu2xre5dEut7ePnpqvLSkCQCegkKLtvbRNWvOrVlzbGiob2ioY/fupsrK8pyc7Ly8vIKCgqKiopKSkrKysoqKiqqqqurq6traWkgH8dSpU5OTkwkJCWVlZWfPnp2cnOzp6enu6urr7e3r7pq9MDn/7t3Dp8/2T07tOX32+t/+u10gICEhAcrjp6SkHD58eGZmBlLxrqqqunbt2pKjjxw5sqzzbWpqgnwuxD8vL6/R0dH/6nl/jICkFGBtL8OMWhUrkI9LlI2MlefGS3B4gMmBMTk6mfnY9BwxHz/ZyFhx/W3SCgoYZ5ev1QpaghMnTmQVFAx1dAzs2BHPYrnY2fkTCGwsNkNPb4ea2l51yfEAMFkEpnPBhWwwlQOfLdp4uXTrXIn2XMnWy6U6l0t0Zou0LldqX07Rnt24cVZz44ym5oyGxoyGxgVV1cl16ybXrZtcu/aCmtodQ8NLqxVvDHW3dB8BIEZYuFtG5rS09AUJiROenm0USpaTEw2Px+JwhlZW26zxpjY4vI2VlZ2tLVRN6OzsTKFQoqKi0tPTKyoqOjs7s7Ozk5OSjh89cu/WzeOHD3d1dGxvaootKnHhJ5nEJshRg2D+Qcoc3sbEdNeqHTXjE7e//6/oIoD4D4iOjt63b9/09HRLS0tdXV11dfXH1SivXr3auXPnx5EHlFum0+kMBoNOp9Pp9L+4L/QnwEhNB1Z2f5CPlyQdFikdEiHL4spFxclz48Wj4pAcnrwgTTqEBQNglZSUqqLiX9SaGBoaysnJmb1x4/q9e/WennvWrDkiIXEegFkArgBwBYA5MaEZvvClYpGLuSJTObALhTpTpbZTJfgLi38q8JOpuHMo1Dkz1DnUMj/nzc1vurvf2aA2TPTHEKoByEQgRg0Nr+Fw3xgZ3VZTu6WoOCsnNyEru09BoVpJMUltM1kLbaqjr6+/VXvbli3btLX1tbUN9PRMTU1trK18PD3ZoSFxnCguh1PZuLNw1x5iWqZWSLg0JQDm5QuIZJgnSdSHohbBcc0vcS+pNM3IXR+frClId6+uqxmfuP2JGXF/Dv8iX2xsbHJycm9vL7Sxs3379sUB7wJmZ2fLy8uX+NyqqipI3YfBYFAolJSUlP+9jA2noAhgbWSYkQoxfIWEFHEaA+HsIelHlwoMkw5ly0Zw5aLi5KMTFOKTxdEYICtHZPxVDbw9e/YUFRWdnp5uIBD6ALi1detDC4vLYmKX4PCLwsJTQsKTQOisPfxUIfx4KuxIIhgWqOwX6O4XbBnkaw0maA0kbB5I2NyfuKmPuXHf+vV71dfvXb9+7/r1+9b/8Qf0974NG0ZVVKaRwAFgAYgBIENJqR+Nnra1vU4g3HJ2vuvsfI9A+NbK6rGZ2ROdTU83Ys5qJieqsqPXBTDUPLw17Ry0LTB6hobb9HT19PQ2GZtoWtls8vFd60+XIFOBBwl4kkV8/MTJ/lIkfykfirQXWcrDe31giEGsYJsg1Soz37WwzLmw3DQ9T52XvEGQ5lXbsPPEqfs/fMVOxqfwL/LFx8fHxMSkpKRANVR1dXWtra0f1369e/euq6trceTR3NyclZVFo9EYDAaDwfD29v7aDeb/CGKKioGllXQYWyGGL5eQohTMlEBZAH1DgLVGuntL+tGlAkOlQ9my7Bi56AT4Jq1Nenojhw79lXdsbW3NLyra19GRCMBeaekZa+t7Hh6XVq8+BcAEDHYUgEMADOBBRzyoDwYVNJBBBEmOIMsTZLiDdDeQ5grS3EAaEaTZgHgA4gDgAZD0YTgTH4AsAPIAyIOBKgC4YA0CcAFIACBeSqpSRaV/3boRTc3xrVtPGRqeR6Mv4fGX7eyuO9rddws8611V7lZWbVtShS4o083M1xSkqUXFqpD95Tx9JCgBSP9AUUoA0pcmTqYuEE7aw0fKjSjp7C5JcBGzIyDsHMWIJJmAYMWwyA0cnqEg1TrrDxaapOeq85I2JWV41TY0Tpx68BdY+G/kg/hXUFDQ0tICGb9lZ4YsiTwW+9ygoCBfX98rHzU6/A+QWFEFMHjpULZCDB/Oiglu2XXrm2+KdjZhAgIRZuYQC8U8faQCQxHW9iIASIqL4S0xf+UdDxw4kJaZOdDTEycqWi4mNrxx48Tq1aNweBcADQBUApCNAHwHEOcKF7iJlPqBerZid11iJBUXHWidEEbgM5344S4JbO8gIrY5NeV8V+eFnp7a+PjiiIjBkpKR6iq2L3nrBu0tMLv1gAgAD4BEAOIB4AHAAyAVgDwhUCkqulNCYo+8/F5l5QNqaoc3qZ8x8GyzzEyyy8xzySsmFpX7lFZ5l233rKhdx+IiyFRJX9rHhJMguIjZOYpY2QELHDAzh6EwKg5Oq+wcAQoDcLainj4yAcFKYWwNDs9QkAax0Kmw3CQtV42XtCkpw7e+qe302Udfn7cC0dHRCQkJC+Tj8Xg8Hq+6urq5uXn79u0fj3aFMDY2Bu15LPG5NBqNw+H8v9TKlrftBhY46VCWQnSCMCvGc/u/etSv3rpdtLMZGxAINzRF2jqoU2iSCqtEkGJKdoQ7//iKQtclOH36dHx8/NGTJxvY7EgA8gCoACAFgCRVtWwbK7aBaBgOcJxALkmshSnZFQH6swxrGtoFKVl5heUl5TUl5TV5hWVsTlxnbz/0ghcuX+4ZHLz74P6xi5fcE5NF7ewAhgCEEgFIA0DwgXkxMBhTQT9CDsURUQ0XFQ0DIAaAFADyACiHg0ZpW44iI2BdcLhGBGcrl2cUn4RJznDILlANDBX38Jb28JZy9VwgnDDeBqAtgZk5HI1RsLE3IvlSuDEZRcXDBw+eOXsus6LSOy5eieAMjNEAZ4MgkmUDgpXCIjW48UaJaTZZBa6F5U6FZUZpOWq8pE2J6cEtu//x86vPX7TFACwWKy4ubjH/4uLikpKSGhsba2trh4aGln3azz//DB0A7edCcS6DwSCRSIurAf6XKGlpBWhL6RCWQnSCSGQsoWyZZs3Cnc1Az3BdQLABi6tpiVN2cnOtrP3Ti9OrV6/GxcXtP3Dg8o0b1UlJ/tu2+eFwVDK5sn5ne3dLrLsQ1xEkucPKaZKt4WI9bFASZcpPycnPzy8qKioqKsrOzo6IiOjq6oJebWRkZNeuXVfm5nil5UgLLDRTSdzWSkiRCUAyADwA4gCIFFpFVXELMk3mb05PVg4PMzYx1tdDaWnh1dQcVyn4SMj5iVtYIaxtROydEM4e4p4kGTJ1NY2xLpQlTySL2zuJ2zkibRxEbezhllZC5pYqDk6YgEBaLC+jqKipubl/797hwcHBvr6Dw8MXp6bu37nz6MH975/9sGf/kBsnWs7aDhijAM4WQSTL0kOUmJGaH1joVljuWFimHpfIaN618gsI2Gx2ZGTkx843Ly8P6lv+lMDKzMxMRUUF5HMXyOfj4/MpY/nfRvO+PoDGSgVHKEQniLBjHcqqlj0MHxYOcLYKWCsxYSF1BQW4mXnt6fN/7h2fPHkSHx/f29t7+fLl3sFBcmCgX1AQk8VKSEzLEYRy7QDHAaR5ClUHSu2KEO2MAMVJ/jkF5fn5+QUFBdnZ2eHh4RDz3r5929/f397e/s3t2xWtbUDHQMgCK2ZlK2ZlK2ZjLYYhwKSZAERJSwat2+qAcLBVDwkxiuVrxicpMZhmZqYoU0MUyhCN3oZGG5ihthmaGOkYG2sYm6wxRcmjLSQwOATeFmnvJGZLEMNZIy3xkhZYeROzbfYOvJTU4YMHT09MDO7b17e3t6e7e2EARl9f3/79+8+fP3/p4sU7t29Dn/fRkyfNff3u3Bg5a3tgjAJ4O4QXWZYeosyM1IyON03KME3J2iRIXZzY/zwAm81msVhcLnex8YPsX0VFxa5du54/f77sM9+9e7d3796SkpLAwEAqlerv7x8QEBASEvLnqkf/OrqGDwK0pVRwuBwnXiQyzjKveNnDbt27L2FtDzZpIQAQFxbaaOuwJavg2p/Kpv78888CgaCL49bPAAAgAElEQVSxsREaQ0Kj0Xx8fFpaWpJSMoO8MdF2INoRZPmI1AVLtbNge9jChVmCvIKSnJwcPp8fGhq6IA0zOjpaX18/Nzf37d27HpxoYIz6g3l4WzGsNcIcjcRgdUzsnW1sDG0shW0c1OkhRrF8jfgkJQYThUKZmZqaLIKpiYmZiYmZsZGZkZGpkZGhkaG0sakoCoO0wCHNLREOzhuxOKOt2iQisX5H7cTx40eOHIEkkBfPWent7YWGRl28eHF6enrJ8NVHT75r7N3nzObIWNkCU3MxV09JMlUuMFSaEb6KEf54xSV9gM1mQ/yLjY1d4nwhibHPiB09ffo0OTmZxWJBg/+oVGpmZuafuIv/EXQNDwO0pUwo2yA5cz0/FVvwyd6Rqo4uoG+E1DOQ3arrkJyByStxrqh59/W5offv3yclJWVnZ0MqyjExMa6urjdv3vzuyRMjJ1crlFSSC8j3Re4MlexkgWauSl5+YXZOLiQ/uuAf7t69W1FRcfr06Vu3bp06fpwYGgbMLMSsbMVwNkgLLBKNkXAjykTFaIcEOxPsDTGWwjYO6oH/Ip+5uTkahTL9d/4tNPkaGRoa6OlIG5mImlsiMTgkBod09VyHwW1SV3d0dCwrKzty5Mj4+DikQgvpby/wb//+/UVFRZ2dnTMzMxcuXIDmTC/Bt48fl7W2iZmZi2LwYnYEEQcnaSLp3opzgX+QDwKPx1vifDMzMz9fk5eZmVlZWXn+/Plbt25VV1f39n5yBN5/G/uPHQfm2DVhbIesfK/S6i3JmZcWDST6N7x/bxPJBRs3y65avV5ri3Ny+sbEjIqxP7OzWVdXFxERsWfPnvHx8erqam9vb0gYyjM2EW0gnO4OSvwlmpniXSywI844I6eEw+FER0cv1Er+9ttv9fX1AwMDN2/enJ6eLisrc3dz22BlA7fAilpgxbDWkiQ/WXaMPDdBipe0jsXd7OAoirNRDww1ihVo8JKUGEwLCwvzD1JXEOEMDQ319PSgbks9PT1HgoMKFi+CskBicEgLnIiDMy4giEGj+fn5lZSUjIyMjI6OQuqMC/rv0AiM4eHhysrKxMTEffv2zc7OTk5OLm55XsAvr1/LY/FwUzQSbSmCwYm7Ea9/+3CFV+9f5GOxWBwOZ0nkGxUV9ZkOoCdPnkRHRzc2Np46derOnTsjIyOPVlCV/l/CqYuXgJGZEoVmGifwLCzD5xSZ55e8/ETcffvRY4SUlBRCVF4Mqe9F8treoMFPvfr4K/oPINy4cQOquB4aGurv74eUwefn5029ib4YkO4Jq6RLtUUgulmgNME9jB0nEPAXL0vGxsYaGxvn5uauXbvW3d1NoVA83N1JRKKRnT0CZSGMt5Vw95L0p0uHsOTYMTKxidLceAkydX1AsEncH+TDWmAszc0tUCiUibGpoaGpoaEtDhvo51eYlTkyOPjo7t35+Xk8IwToG0LkA+bY9uMn5ufn8/LzKyoqhoaGIEWYBWlQiH/t7e2Dg4PNzc1kMjknJ2dgYODKlStnzpz52A3++NNPitZ2cFM00gKLwFrBHV3P3VhmQPqy+DfLx2KxYmJiFvOPw+EUFRV9qib0+++/j4yMrKmpOXbs2M2bN48fP/5VLbr/WfzzzRt8aDgws9gQFGohSCWXVeskZYTt6vjU8VX19QCBhMsr6LG4niWV6Iw8p4qar1Uzef/+fWJiokAg6O7unpiYKCoqGjl0qLRq+7pthlwCyCGDHcES7WxYZySIDiVm5xWfPHlyoRnq/v37lZWVp06dgubzQl7b29vby8vL19vb1tlZwcISZm4p5uAsSfKTDmLKRnDkoxPkYgWr2DGasXx1XtIaejAWi0XjcMaWWAzBkRQSGpudU9be2Tx2tP3s+bZTZ8tGxhK79q5zchU2RiExOKQFFpjj6kYOz//zn+kCfseuXQcPHmxvb4ck8Bbzr729va+vr7m52cDAgEqllpaWnjhx4urVqwcOHFhSbvLrr79udHGHGZshMTgE1grYOY5emlnh1fs38i3rfCMiIg59Yifgl19+4fF4paWlY2NjEPm+qnnpP477jx8rWNuJ2jpqMSOt07LJ5dtVeUlNJz+pl4B2dROWlVOzxJsLUkll1RrxKWWHj37q4E/h6NGjwcHBvb29R44cyc3NZYaG0iKC1TQcKWpuKc7rG0JkOiNh2wPW5eXkzczO3b59+8SJE8+fP//999937ty54HDLy8s9PDx8fHwg8hGJRJKXl4e7uybOShSNEbO2l/D0kaIFy4RFykXFycbwpbnxMmGRssHhCoEhckFMmeBwWWakAit6dVScRFgkLCAEUOjANwD40oFfoAgGj/zD7WIRtg7ruTz7onIXXsL21rbDw8P72tv3tLa2tbYu4V9vb293d7empubWrVvj4uLa29svX7587ty5rq6uJZqTxr5+wNAEicEhLa2AlV3PqTMrvHRLyfex842Li4uOjv72E+un9PT0vLy8gwcP3rhx48SJE19VRf3fQP/RcWBgJOvhox8V65RT6F5SqcFPm3u4zGLg97dvN6ipSYmLK8rKapD8HHKL3IsrNvBTLz/6upKImZkZBoORl5fH4/FYLFZcTIxPaICWiqszIoksnxepkRunVhBpWN7Y3Dw2emR2du7KlSsXL14cGBioqKg4d+7c3Nxcb28vjUbz8vIikUhL+Ofv5bUJby1kikZircSd3SUpdOngCDl2jByHJxvKlg1ly4ZFyoVFyodFyoey5ENYCiERq0MiFENYiiERSiERyiERa8LY0nYEUVM0RD5RGwcjXhIuv3Rret7GxHRMRi4tvyi/pnZPa+vePXu6PkxshILf0dHR3t5eSOUtPz9/fHz8zu3b42OHe9vbH965Mz8//+z58xOXr2h7esONzJAYHNISD3C2bUdWunpexvJ9HPlGRUUVFxe/efPm999/f/Xq1Q8//PD9999DtaIlJSVpaWn79++/du3amTNnPq7C+t8jpqQU6Bup+AWYxAk8i8qx2YWY/JKfP1r8vX//Pjg4WFRUVEhWbrW3r3GcwKOg1Dwz36Gs+vcVO9+3b98mJCSQSKSwsLDIyMioqChebIwdyctAxsdDKt5vVUGIQhNTrJtpkc9JCi3fUTA2euza1RuXr1zOzs5ub2+fnp4+efIkj8fz9PT09fUlk8kQ/3y8vf18fFzcPTStbcUtsAhzS6S5JdICJ27vKOlNkQoKU2BGrmUw1waFrQ0KWxsYuo4eso4evDYgeC2NsZYatIYauMaPruIXoEyhKVMC5Fw9EWgMEoNDmFtKOnts46fa5xS5F1e4FVda5hZrp2ZrCtJMUzL98gpzamr3tLX1dXT0dnS079lz4MAB6EqNDg/Hczntra3T09P7jxyJKSpx4SdiBSlrgpkwIlnYAiuGxvxBPqz1jqFlOj6XxTLkg9LOS5xvVFRUfX392NjYwMAANCLi0KFDZ8+ezc3NTU5OhkSQJicnZ2dnV0yS/xbevn2LDmQAFGZDUJiFII1cVr01MSN89/K1DvV1dbIbN4tYWqkFMy0S08hl1VqCtLLRIyt8r+fPn0OTvcLDwzkcTlRUVFxsNNbR3Vyc7ikjCFAsYa5uYEt30gLtHXNgTjmikdX4I0ePnDtzHnIXMzMzAwMDfn5+ZDJ5gXz+vmSyj48xwVHC3BKOxiAwODEbBzF7J4QJConGiFnZint4y5L9VxHJcp4+su7eMm5ESWd3cUdXhL2TiC1ByNoeYK0BBg/QlsDUApiggTEK6BuBrfpgm4mYp498UJgyM3IjN944Mc02u8C9qMK9pAqfX7o1LWeDIM0oOcMvvyintm73rl1HDw6/+eX1699+m/v2ISmevy0odBOTLe1Ph3lTANEXeJJEvSmSvjQxK1uEmTkSg0Ni8MACl9G+0rKS5cm3bOQbHR29e/fu0dHR4eHh/fv3Dw0NQauc+Pj47u5uSAHz+PHjyw7J/R/jm4cPZXHWCDunLQuLv7ikttNLmwx++OEHVVVVJQUFqXWq0s7uGzg8VEYuKj1XMVYws7J8wfv373NzcwkEQkBAQHh4OJvF4nLCzVAu1shwL7nkIMWKCIWmUIUWXbqzc6kYsVTENg9kNTP2tHaXlJRMTEzMzs7W1dV5e3tTKBQKheLr60ulUOw9PBSxVjCUhSgGJ4a1EsPbitk6IFEWSLQlEo1BojFiOBsYBg8MTYEJCpiaA5SFGNZaztZhnbPbBnfiZi8SOijEnhXlkyCgpWYwc/JSa3aU72mvbO9wjo6VsbYDllYwB2ekl68sPViZGanJ5RkJUq2z8t0Kyz1KqqwLSnXTczcI0gxTMr2ycp3SstaHsYW8fIXIVCGSv4i3nzjJX4rsL+XjJ+XlK+3pI+3hLeHgjERbIjE4YTQGmKB7T65UiGh58i3rfGNjY1NSUhoaGnbs2FFUVFRRUdHW1paXl8dms5ubm0+dOnX16tWRkRFI7W9xj9n/C3pGDwMDIznPPxZ/bsWVmoK0K/+eTHn8+LG4goKItPRWEZEuMfFyjY1r6CEivGQQGhm+q32Fb/Tjjz8WFRbGRUfnZmRwOBw7KtlAl+iE5PjIpwcrVkfJtVLVq0V9IrSjLbyKhOwyQFC2eU5acVPTzvPnz09NTaWlpXl7e/v5+VEoFKqfH8HTUxSNgZtbIrFWYjhrMbyNGM4aYWaOhPwaBieGwYGt+pvcPNr2Hxg7c+bE9PTklSu3Hzx4/P33z1+8eP36l8/Pm3j05Luw+ARtRxcZKzuAwQN7J6QXVC7A1uDEbeOnWmXmuRWWeZZW2RWVSwQEA1eiiDdFguQvRfKX8qZIE8lSi2phxO2dRK3tYVhrYGoOdA3gRqbMwuK3K+6X/ST5lnW+8fHxLBbL0dHRycmJRCKFhoay2ezw8PCqqqqxsbGrV6+ePHmyq6urv79/cHBwfHz87t27/48U5BaVAANjFT+6SZyAWFRumV2ILSx7/e/SxDVUaioAQwCcBeAyAL0Kq9ezokGMwKOi5qvea/zCVGx1jQaVDid66G8McBeLoazKCVWsjZbZ7aydB6eQFfwcCUkIQrqwR7oKPyV2sH/o4qWLx44di4iIIJPJ/v7+fn5+gf7+2vYEYI4Vw1lDP0gM7t+YZ4kHugYbCc7frDiRuwQ//fhjRkpKc0NDXUNDcBzPxJskb20HMHhg64jwJMlQGYqhrA1Rcdv4KVaZecoBDAlPkpQnScrdS8rVU9LJTcLB+V+1MKbmwMxCGm+zydXDNZzVuHfflQ+7wCvE58i37J5vQkKCi4uLsbGxmZkZCoXCYDA0Gi0/P39wcHB2dvbixYsNDQ2VlZVdXV0DAwODg4PHjx9/8ODB/8vo4rdv3qDoQQBtuSEoDJOYRi6r1k5MZ+/pWjjg7oULRcLCewHYD8AIAEcAuAjAoMIqVUY4pnrHZ155AbO376Q1txqzokRdPYCjq4yPrxo1ALcmxF2SR11dyFxdHyfZboLji7n4GdLRHiVw73IJt3IQVK5zaHh05tJsT0+P/yIEUql6BCcYBi+Gs0birBHmlggTFPLDzpiYJR7obVPBW9958ImdmxWgtbU1JSWlvb29s6NjZ11dU31daVlZeHyCua/fKht7gMEBGweEp48MNUgxJELa3esP82ZlB8yxwNAUGJkhMHgVByfLQIZfTFxKQWFjc/Penp6D+/d/9/X7C58j38fOVyAQJCQkeHp6otFoSOnD1NTUw8MjNTW1s7PzwoUL165dg0Ze5eTk7NixA6Lg/v37JyYmFo9A/p/h9v0HkpZ4hL3TlvAom/QcUvl2VV5S+7k/1MnHq6qYAGQBUAtAJwD7ATgJwGkYLHutalBBxWde9sb9+yVdPWhODNLFA9g5irt7rfOjaQUEaQfTt/hTbOWZntICumIpR7aNaFikFhGi7sHj2hT4Vkh6liE9ipHOucLtfY0Xzl+srKwkkUhUKhWqzKBR/T18fCQweFFLK6Q5FmGKhtZSH5hnqIK3vnzzz8/VePDgQUxMTH19fUdHR11dXWlpaXV1dd2OHa1NTbuamqqqqzlJyVh/2mobe4DBA2t7gMEDA2OwzUQSZ2NA8Q/LyeNmZdOZzL7+/quzs8fGxoYGBwf6+/ft3Qvd6K/dYvgC+diLCq4SExM5HI6DgwNk8CAZaxQKZW9vHxsbu3PnzpMnT964cWNoaMjOzg6aIQZRENqlHhkZWXZz8L+NrkMjQN9IzpOkz4lzyilyLa7QTEx/+PLlnra29atXR4mIxAEgAKAIgE4A8hSVVF3cZV08LH2Ztx8uTfg9ePKkuq/fJp4v4UYEdo4IN+IaCnUzLUgnMGgLw39jAFnHk2FjkuAoGUWUSw6RryZopctSfDYGh6iGh2x1TiPxtrgWANtkGCFBtrev+8LkVF5eHolEgqZyQsYviEZDOTnDLLBiWKt/87YGRopYq6tf6deWoL6+Pi0trb29HZpMVl5eDjVWbt++vba2trGhYXdra3tbW01tLS89w5YeZEqmJFZWDRwdv/fw0fy7d/Pz80//9rcYLnff3r1TU1MjIyPd3d29H9DZ2Xnq1Kmv6t35MvlYLFZ0dHRSUlJISIiNjQ0Gg4EErBc01LFYbFhYWFVV1eHDh6GpSz4+Ptra2jgcjkKhQNUJLS0tQ0NDIyMjyxZH/LfBKSwGBsZr/OmmcQKf0irr4irb7Q3r1m8QEhU1lpcP/TA6PFFUVAFvA9yIYh7eMHdPeZJfTmf3z7/88uzHH9sOjbomp8oRScDOUcTFQ9nXfxMtSJcerBNI16CTNH0oaGuur05lrOretHUjAcrFZLmsqDUtiubOQi52imT/LcFMlZCI9aF2luFgGxnO4vsfGj58/vy5srKyBfJB/KP6+wf4+6/BWwthcEgLLEQ+YSPTVTjrs1f/Ug713r17MTExjY2NHR0dUMhYXl6+0NhbU1NTW1u7Y8eO+vr6pqade9raOnfvPnn82JIX+fXXX/l8PqRPcOzYscXkg/7+KsH7L5MvKiqKzWZTKBRIQNjKygoSEF7MPz8/v+zs7H379p07d252djYtLQ2aSbdt2zYrK6vAwMDU1NTm5ubR0dFDhw5B57d4F/X9+/fv3r1b8qV59+7d4pXikodfhTdv3pjSAoE5dkMwUzs6fp2FpaSWNlxrqzACCYTgCghEiLJyhpCQk4wssLAUw+DEbR0kXdxFXTyAneNmRug6/wBg5wh3dlck+22kBerSGQZ0xhYadS3FU9PV39YiNUK7LVVjOG3TcOLWPr7evnCNeoZ8ddb6Y1TjarilqYSLmzKFph0SLusX4pYWc3xsOCUpHSrVrKqqgsi3mH+BNJqLlxfCHIuA+GdmDlAW+KDQ+RUXaS6L8vLyzMxMyOyVlpYWFRWVlpZ+in9Qa86ygidlZWU5OTknTpw4c+ZM77+jq6vr0KFDvyynVbIsPke+iIiIyMjIkJAQd3d3Ozs7SEYY0hBebPxQKJSbmxufz29raztx4sTc3Fx7e/tChZmKioqhoWFgYGB2draTk1NcXFxtbS0UrAQHB79+/frFixeOjo6WlpYEAkFfX//mzZujo6MGBgZ4PN7ExARSSSORSGg0GofDodHoxsbGP3Hpb3xzT9GOIOrqKWRtBwdAU0lRZrMWbLUiQkQEwGB+2XktRcVoKWkhPX1RIxOkGVoMayVuR5Dy9BH39JH3JmtSA3XoDAN6sB4tUMOXLO/loubo64TOitXtStM6wNfeG71lT+TGZqZaXaBihZNYnJdMKlexo3TLBYJZCsAaS7kR1/gHaAUz1SJik2obc1JT+vv7z58/X1NTAw0jXsI/Bo22zcERWOCQ1vbCbl6AHZOorvEkPPxPfHAIIyMjkJx6Z2fnjh078vLyioqKiouLl+UfpL3S3Ny87GZpf39/XFzc6Ojo5ORkf39/T0/PAvl6enq6urpWPmTvk+QLDQ2NjY0NCgqCZIShMTqQhvoS44dGo21sbNhsdnV19ejo6MWLFycmJtzc3LZt22ZqaqqoqKilpQUp9q9atSorK0tTU5PBYBw6dIhEIsXFxb1///7KlSvXr1+nUqkoFOqXX35hMplRUVHffvvt/fv3nz59+vz5802bNg0PD1++fHlsbGzr1q1LxpOuEKkFhUBOXsLQWEhcXBQOE1ZWgQsLI0VFRWVlEeEc+ZSsVUFhMlYOYlv04Ub6CEMjMWt7eQrNmM01DmHqUelaFOoaLy8JV3tlG6KdSUrUlrYEjW62ehNDpYoim+8qnGQDODgQ7iQb5bMpxkaMGShfKVh7oMzwgp4ZHeDNZDy8VWmBm4KZEmT/wPiEQwMD586da2hoIJPJAQEBS/hHo1L9/fyU0RbCOBslZ3eujt4pAE7A4S9nVlowshiTk5NcLre4uBjSligqKsrJyVlQ1fgU/9rb25cd2js3NxcZGQnpCxw6dKirq2ux8evu7u7r61thN/7ye7tMJrOwsHB8fDwmJsbe3n5Byd/BwWFZ42dhYUGn0/Py8gYGBiYnJ2dmZmJiYnR1dc3MzJSUlPT09FRVVZFIpIeHR1JSEoFAGBgYuH//fmJioru7O3QeZ86cAQD09PTMz8+TSCR9ff3w8PD8/Pw3b968fv3a0NBwoRIJg8FAun1fiy2bNslKSCitWweIZOEQlug2YxEAkEJCCL1tcvHJMhyeTEKyLD9FzSbAcDVxrZ4zwtNjAyPMJj7RIDxS1tVVxAEviyGYb41irK0Kld3uhci0AzE4EGEjGuG9Po7rULA9sX1s7+kHdx6/evU63CrTFsZhrW7J1jyea3ZC0cReyAYrSyStD2BohoSvpgeX1NWfP3Wqra0NGk+3hH/+/v5UOp3m6OiLQAqEhPYAcAAOPwrAjKXl137q27dvx8bG5ufnb9++vaSkJCUlJSMjIzc3d7GqC8S/ysrKhfijrq6uv79/2Xz1Tz/9FBsb29TUdPr0aYh8PT09i+1fV1fX6dOnVxJ5LFPVEhERUVBQMDw8fPDgQRaLRSAQXF1dISV1SEb9Y+OHQqGIRGJycjKkKnn58uW6ujpDQ0MzM7M1a9asXr1aTk4OmphNJBJTUlKgs5SVlT34QXb48OHDERERenp6ly9fzs3NZbFYtbW13t7eZDL5559/1tfXt7S0dHJyWr9+vZaW1uuvXP309PTs2LHDCo8HcLg0Eunu5GYbGCYkJYUUFRUSEhInuEiHsqTD2LKsaOnYeMVIvpNyvDTOWYbibxoZjY9LUAoOEccQtBV97OExjoBnA2O7KXGZFpmFrJ19jWNXLtx68XypHtfV6duWooEU6bxY5Z4yvelY014RUxOkvZ2cF1kzMEQ1KFQ9mNnR23vy2DFo4MJi/kHGz5NIrG9p2e3vHw5ALgDtMNiokNA4AN/t2bPyD/706dPExMSsrKzt27eXl5enpqYmJSVlZmZmZ2fn5OR8in+QEO2nRKtev37N5/NramoOHTrU19fX2dnZ8wELxu/AgQMr0ShbxvJxudyMjIySkpLMzEwikejm5ubm5rbY+NnZ2S0xfmg02t7ensvl1tXVHT169NKlSyMjI7a2tsbGxsrKyqtWrVJVVdXQ0DAwMNDV1aXRaGlpaerq6iEhIUuCo/j4+AXtaQjGxsYjIyMYDKajo+P48eNtbW0mJiZfNcZkdHQUAIBEIMgMBlZ7awkA9wGoFhICQkIIUVEAFwLGKBGCiyTJXyogGMEKsdmWabgpFHg5b2CE2fD4BpFcIXei+VpGuHZ2OqVmd+ng+fHZZ999uUemgN1oAYLDVtUlqg/XmlzzNiwCKF0JgpOCj+9mRphSQLBBJPfY+HhD3Q4fH5+PjZ+Xl1f/gQM///3vXBmZWACqAOiDw48CcG7Nmjcra89+9epVbm5uSkpKdXV1ZWVlRkZGQkJCWlpaeno6xL/c3FyolW5B1Wox/z61dHv16hWfz9+xY8fo6Gh/f39nZ2d3d3d3d/cC/6DfKwl7/yBfZGQkJHgdFRUFtQ6lp6czGAxXV1cPDw83N7dljR80ugTyvJaWliEhIUVFRYODg2fOnJmcnAwLC9PT04MmGqBQKBUVlc2bN0MLQRUVFV9f37m5ubm5uczMzIVCrJiYGE9Pz6qqf3U96urqjo2N4XC4BRfg6ekJCS9/Ef/4xz927dolEAig2UOBTGYZCtUGwJSQkD0cDkRFheAwemgoMzdfxsIS6OgDO6uNmHD/VZUyVk5Sfv7aXB6Oxxf3obgmpj+48ejN26/TU/vx2U/Oa1juyGSOYnuW9rFa02smekxgoS/p5Laa7LclmClPDXRISj05Ph79kfHz9/cPDAwcHBx88vz5SElJEAAZALTAYIfg8KMA/HDky0U3v/zyS1VVFZ/Pr66urqqqys7Ohm5rcnJyamrqEv4VFhYu4V9zc/OnglaIfHV1daOjo319fR0dHV1dXYv5B4UdFy5c+OJJgsjIyMjIyODg4ICAAGg/jc/np6enJyYment7e3p6enp6uru7Q8YPGiPxKeNHJpNTUlI6OjomJiYuXrxYVlZmYGCwevVqHR0dc3NzfX19ZWXlTZs2ycjIqKqqBgYGcjic6upqOp2+ZcuWmpqaqKgodXX1iYkJKEe9Y8cOCwsLNze358+fa2ho5OfnNzc3czictWvXXr16dSW3Hxphv3HjxtjY2JTU1B///vdCE+NGAPbBYOJwuLCoKAKB+OHp0/n5+fuPHuXv3GngTqbK5MbKeNVLIPbr6uUxQjZHxcA9vC//2dxk/87DZoAWKF+RsHagxOhCocF5ZT0HuKWJlIuHki91S0i4JIUWWFza0dpKJpECPoBGo5HJ5NjY2KtXr05OTd29fz9LRyccgFIAegDYC8BPH/qPPoXbt28XFhYKBILKysrq6uq8vLzY2Fgej8fn81fCv7Kyss9Q59WrVwKBYIF87e3tXV1dS/jX3d09Ojr6RQU6wGazIeX40NDQqKgoSKsqMzOTyWR6eHh4eXl5enp6eHi4u7svMX62traLjZTNabQAACAASURBVB8ajXZycoqNjYXK/i5cuDA4OIjH49evX29gYIBCoVAo1JYtW9asWaOsrKyioqKhobF161YSiXTmzJnS0lIvLy8GgwG1df34449JSUlubm6FhYXQB0hOTvbw8PDw8GAwGHNzX1bxfvLkyezsrJaWFmTzFiTSc8zMdgHABgCIiMDgcHsnp8Xr4mEP72YgWQvAOQTioYnxaxw2Ts/As2BFVnZZvH//LhSbbgvjsle3pGqO1phdjdmyT3SboSjOUsrNU9mPZhAeuZbBjK+qFsTFLTjfgIAAMplcWFh48eLFmzdvTs3NnR0eTlJXZwOQDoefzs//zDu+fft2eHhYIBCkpKQUFhZu3769uLg4Li6Ow+HExcXFx8d/kX+lpaXNzc2fETx59eoV1FM7OjoK9fZCrZaL+dfd3b13794vxrzA39+fSqWGhYVBZk8gEGRmZiYlJZHJZC8vL6ie+1PGz8bGBhqaCE3sxOPxYWFhJSUlBw4cOHv27JkzZ6hUqqGh4cIYdwjGxsa6urouLi7ZGRn9+/adO3fu+pe+yl+Fubm5VatWrVq1KioqKjAwcNeufwk4FOPx2wEwBQAgEACAhry8hf86U13dBUCjCKwHgJn16x8QCN/o6x8C4PrMXyqPvTx5EyNCp0jnxyr35uhP1BndImoWAuMtSLy1ohfJihuLi4nXZUX19vbGxcaSPtg/CoVSWFg4PDx86dKla9euXZiZ+e7bb2cOH77/WQWmb7/9trKyMj4+Pjs7Ozs7OykpCVpDQ9WZ0dHRH/MvIyNjyfqvuLj47NnPTYh4+fIln89vaGiALN/ibvPFJrCzs/OLelGARqMxmUwWiwUt/iDdFkjpbKGfYLHxgyKPBeNnbW29eGKsn59fenp6d3f3iRMnLl68mJ2dra+vj0KhIPL90clsZLRNX9/QQJ9IC8ivqLh0/vylyfP/qZ7L169fQxObAAB+fn5L/rfK3j4dAElhYVFxcVEAzn0Yo/D4xo0WUdH9SOR2GOyEmNgtNPpbB4cLCOSZDzr/fwWFkVDkUZ+oPlxiNlm15YrhxmBgqqPk5KpNpa/1p68m+7fs3n1oeDg1NZVMJlOpVD8/v5SUlPr6+kOHDl2+fHlmZmZy+nOjpn///ffx8fHk5OTk5OTc3FwotggLC4M0JFgsVmRkJIfDiYmJWcy/lJSUtLS0jIyMrKwsKP4tLCxsbGz8fDLh6dOnHA6nqakJsnxLus0X+NfR0XHs2LHPJ1zAAvOg9B6NRoPaCJY0s3zG+C2kXdBotJubG4/Ha2pqOnLkyNTUVEdHB2T2FvPPzMhI39BQwdlNPoKrwUsillS0HBg6Pjb2J+/tIiQnJ6upqUVERLi7uxsZGX2sj95CoaQBIA2HAxgMALBm1Soikbins7PbzOwIHN4kI9P9wezdMTAYA+DJmZU2Yn0G//j7c5e1bCjyyNQ+WmU2l6Z+RErfXBSDknV0EXf3kvT0Sc3L29fTMzw8XFBQQKfTfXx8YmNjIbmmw4cPX7169cKFC8uGn0+fPp2YmKiqqkpISMjKysrJyUlJSeFyuZCGSVBQUEhICJPJhDarlvAvKSlpMf+ysrIKCwu/KCr/9OlTLpcLkW/v3r0L3eYQBRf419nZOTAw8PmEC1hgXlhYGLTU9fX1XdzMssC/Lxo/c3NzaFB2RUXFgQMHJiYmhoeHCQSCsbExtOYzMzMzNzHWMTaRxFoh/YO2JqQ4FpQZpGav56caCVK3Dx9aUun5VXj+/LmIiIiQkJC4uPinyrf2RkdHACAJg4FFQAEwBsAxVdUaOPykuPgtFOpbe/sLCMRpB4c/fTJLMNhyZCHyKDA+XaN7nbihGFgYyBCcpDy8kZ4+lPCI8uLipqYmqIs2Pz8/Nzc3KioqISGhpaXl+PHjt2/fnpycXOhZfPHixdTUVFtbW05OjkAgSE1Nzc3NzczM5PP5kAWh0WiQPvEC/z62fwKBAOJfdmZGQVZWaX5+086dX8yhPnv2LDo6uqWlZWxsbN++fa2trYu7fRfUNiAWfl4d+Q+hoNDQUCqV6uvrC9Vz+/r6Unx9qSQSxduLQiSSiMSVGD8o4cJgMPLz8/fu3Xv06NHx8XE/P79t27ah0Wg0CoUxM92MQovhbERsHGSIJAMuzyo1yymnyKWg1DyrQI2XZJpdmHPg4N2vlEp++PChtbW1ra0tHo9HIpHe3t6fKp/+7s6d9LVrvQDYCsCGNWvEJCTUAegCYFpFpXr16lYALm7Z8sjb+66h4RgATz679PkqvJ9/H47PgPY8UjRGKywvVWrP6egHIQlW0h7eSCIJ702KjoxMTk7Oy8vbvn17a2tre3v7zp07CwoKSktLd+3atX//fsjNTUxM7N27t6ioKCkpCVq6QZLuqamp0dHR0BwKaN7sAhgMRmho6AL/uFwuxL+EhASBQJCVlhoeE2MVyiREsM+vID9y584dFovV0NDQ39+/Z8+e1tZWqNt3seBBZ2cn5IiXdPguAWCxWCEhIVQqlUKhQMXcFAqF7ufnTSLpUqiaoaxtjFAHEtnHw4Pk7kZ0d/+M8VtY9mVkZHR2do6NjZ06dSo6OlpfX98CjbZAma03txC1skXYEsRsHSTsHFf7UDSCww04cZjENIesfNeCUlxWgQYvaaMgLaR118TVlSY48vLyAAAwGIzNZj98+IX68pfPnh2rru5JTEzn84NCQ+kAjCGRh/T1I4SFW8TETpua3iQQJiUl/4NmD8LVqdsYUbqvVF7Chv5qt+kWwjcMzSakPV7agyhKJDmGhFFJJCaTyWazoYRDfn5+dXV1dXV1eXl5SUlJYWEhlA1OS0uDOCcQCOLi4rhcbmRkZFhYGJQso1Kp9OWwLP94PF5GUiIxOATp4i5Noa0LDPUuLHn1JWHPw4cPs1isxsbGXbt2NTY2tn7oNv9YcKOzs/PzFZwgICAAKmNcqCcLolHtPTzlHF0QwRF6aTkmucWagrRNERwzaoCjJ9Hb1YXo4uyyqM4AyvZBtVVGRkbu7u5JSUltbW2jo6OnT5/Oy8sz3rYNjUKpYLAi1vZIW4K4LUHcliBmYy+KtxWxc5R291YNYOiwuKj4JJu0HJe8EkJesW6GQMW6xxZ/d/fup7/++slKKkgtIDo6WkFBQVRUtK+vb9nD3r9///Lly927d4+MjHiRSHaurpv19SVkZBSlpWMA6JKVPWlqypSQ4MPhPSoqB8TFuwD4/uvn6XwRZXGteBDO0tiZbnwwZ/PxsHUt0jZ2Uu6ewN65tH9wZ22tra0ttFALCwtjs9k8Hg8qHV/cySAQCKAYNioqKjw8nMFgQHeQSqXSaDQoWP4M/8LDwyH+RUdHJ/F4TgGBQs5uSrQg67gEr9QMWZLfF/UG6urq4uPjIcI1Nja2tLS0tLS0fiR4AEXBn9/nAJCuHrSlE0ij0alUIxdXEUu8sJ3jmuBwfGqWW0Gpa1E5vqBMNyN/fZxgaxjLK4oTHhHB53KS+XwuhwPtjjAYDF9fXxKJ5OvrGx0d3dDQcPDgwZMnT7a3tRqjUHIYrLCNvdgC82wdRK3sxNEWquYYGbwNQFsK2Tkq+9K0wthGMQm4tDTH9HJb++u6W28rKMwZGl4pKXn83XfLLAfXrFkDAFBXV5+enl6sqQBNpjx48ODg4CCbzUahULq6ujAYTFxcHAAgKysLrfZgAGiJiERLSMSKi4tKSGirqQUAkCUiMvEXxgR/BlMTVyxAoI98OlOpIU6hN0KlVcHKScrdHdg5Jrfunp9/z+Fw8Hg8JF1ApVJDQkKgbafw8HDmB0RERERERISEhNDpdMhTBdBogTRawAfmfZF/TCYzks1O4HLxFD+4i/taerAtT+CRkm4SGQ0cnNuPLi0gXYx3796lpqZmZ2fv3r27tbW1oaGhqampubn5Y/5Bv5cI+y0BoNPp0FcnmE4nUShqdgQ41gppZYe0tl/lRdZiRhrFJGCT0glZBW4FZc5F5eZ5JVqp2VpxAnZ907mbt95Bu17vfn/58uXf//73n376aWJiIigoqLKy8sCBA5cmJ0tra6Us8cLWi5hn4yCEtZZGY3QMDbEosyguNyIlTZdEASgMwNvKe5E1woN03GqMdKex2Flb21vGxreUlC5ras7xePevXoUkf38vLCxKTU01NjYWFRXV19eHugcOHjzY1tbG4XA2b95sa2sLg8GkpKQAAPLy8hDbhISElJWVpaWlExISkpOTN2hoiMjIaKqr60pLAzgcAMCg0b7/7DLlr+DK5G28SIinTFKoYm3s6h6Ococy1k3SzRU4OPkXFM/Pz//4449UKtXOzo5IJBKJRB8fH8pHgNwUhULx8/OjUqlBNJq/v7+nn78/lcr4Ev8CAwMZDAYzLIwbEWHmTRJy9VQLCrWPT/RITjNic4GTm3Zg8G/z779/9HhoR+Oxto5fPxJYfvr0aVRUVEVFBRQYQTWnH/NvwQvfuvW5jhNA8fOjBwRwIiIIJLI03gaOsxazthezcRCzcRCztkfYO8l4ktQCgreyuKa8RKvULOfcIvfCMruCMp2UrM1JGcTahrYz539YdJbfPnwYFhZWs3376ePH08srxHE2wla24h+Yh7C2A0ZmUv/H21cHtHmu7T/BHQpFKrQFOipQ3Iu7u7tL8KDB3d2KuxMISUhwd6eFlnZtV9l2dk63nXXW7mw7y++PZ81SSmnP+b7vd//VBUby5r3e+35uuy5JGTFxcVkpKWkZmSgUam5q8tPDw8KaW0pOLgyqakBJk54zh/909yefEKWkFm/e3NHROVRReSAoeHD27J6//4vY2FoAADMzs7a2tpWVVVBQkJiYmLa2NgAAoo2Tk5OSzLKwsNDS0jo5Ofn7+zc0NPzzn/+EKdirV69MTU0BALT09Orq6pqamjbW1l+9Ubv7v7Dnj/+mzxVozh7nw18Vwdcbydd3TtmK1cwYGJroxCfC33n06JGpqamRkRGs8MNqq52dHaxCQPw5OTlBCHq7uupZ2/CYWfE6u1929zZycfV1dfU4EX9enp7+Xl6Slla0ZlbCXn6GsWjzhGTJoBCgbyzm4f3Nzz8vYIYd+C6ZI9hcTp3LNLD88W3C9M3NzYCAgNra2s7Ozvr6+lu3btXV1UHhtCMQbG1t/TD40lKSC/PzjXz96dW06DW0mbX/RB6Tlh6QkedU1eDS1AEKKght/dN2zsLe/hIhkcqxiTqpWaY5hSa5RfLJmRdR8dcT03xbOsbuHPz6++8v//5VODKoqa7OPTYeKN2k09Bh0TVk0TFg0TWgVdUEN6RjSsvGiMQAPz8ZGRkxMbHIyEg8Hv/gwYPlhYVRAr6q8ZaFZxQHRyQA4QBk8vA0CQvjJCTmlJS2tLTuamh8euXKl8zMBfT0gIeHBwAgJCQEAGBlZaWg7fTp01xcXI6OjjBmPX78+N1Se29vLysrq6CgoJaWFh0dHRs7u729/f8u1N61b7/+zvx8mAlLlDdfRThfdwzvoIiCI4upIY2RuVxIOIUadWVlRVdX18zMzMrKytramhp8EH9OTk5OTk5eLi4allYMxuanXTw0ImM0Y9Dcbl4yTi7urq7e78Gfl4eHl5vbFVNzWgubT3wCjOISTNFJ4gFIoGuogYr+24sXbQmpRoDZg18oVkMv2dzahessqfqtufG+vr7Q0NDm5uaOjo5bt27Bmftj8Qez4CNylUcMZOTkfGJqDpTVGDV1IexYdPTp1DSBmIR9fEJnd3dmVlZyaZmyuyedshqQU6LXNxZwchf1Q0qHx6iiU/TTc8xyi/SzC8TjUy6g4tXyS8Jb2t2CQxTtHYHSTUYtvT99nq4BULxJJ6dY34+Bb/zrr7/Ozc3BtAuPxx8eHsJSAmlkZGJ0pKmpNS6u+caNLACCAEji4Ki9eHFQTGxKXn5dX/9vFy86srICXl5eiDY2NjZmZmZVVdXs7GwUCvX5559/cE3Tw8MDOsjk5GQREREAgJaW1v+1atLPP72yFUEZMkd48pWF8XXGnR6+LuvObKrHYGop5OHzA1WBrbW1VVVV1dLS0srK6ojzc3BwcHJ09HR2VjK3oDexOOPmBXMF5dAIHhcPBmd3QWc3SxdXXzc397fx5+3p4eHqesnEjN7S7qpfkEl8okl84lXfQKBnZJaafm/3doKmkTFgRF6TTjAwTTQ2D5NRNgXM/Xkl1JdQUFCQmJgIoypl5+NY/wc5/07m7gHnTC2Ashol1LLo6AN5JVpZhfzGZjKZ3NPVVVdb++zx4631tdLq6pSaW9dtHYCsIlBSZTW1EnTzvvYmHBtl5ZvlFaun515LTOeycQDKqn8ltjoGQEaeX1tvevUo7/s333wTHx8/PDxMAR8Wix0cHMRg+paWJn/55fXAwJqaWj4AQQDEMDNXnD/fe+3aKg9PAQDg9OlTkZGRXl5ee3t7T548+eXjCtSvXr0KCwu7evUqJycnLS2tgoICLEz+fxCL+/e//+0pm6RHH+rBVxLK34HmwUtJ+jGZ6DCbWXHbOT3/x18R/+eff3Z1ddXU1HwXf44ODu6OjjKmZnRmluc9fHSj46wSU+WDw7kdXVitbDkdXFicPTic3W+6uHq7uXm9wZ+Pp6eri4ugsRmDtb2YP9IUnWQcl/CJtz8wMrPPzhltbnfnF7Zl4kEpqiWZWsbpGgZekTQFrJanL3zx2RPKp3r58mVoaGhRUVFXV1dLS0t5eTncuYT4o7hAiD9ouyfO/QM6VU0WeMLT1mfS0gU3pK5aWM9vbMIvKz8/v6en5969e6OjowN9fWQy+bdffx1fWvZMSeXXNwIyCkBdm9vGUcjL/0ZIpFJsok5qlnlu8RkrO3qNP895TNr64Ia0jIPzw+NKPi9evEhMTMThcIeHh6Ojo4ODg1gsdmhoaHBwsK2t7c6dP5+bubm7jo61tLShAIQDkAdAjbV16+ef/zdbwDMzMzAFUVdXFxQUZGBgEBYW/i/+zn9noXo5WoggN97CEP72BB6Cklgoo7EWq7kVi6XNwWdPqH/z0aNHPj4+WlpalpaWbw5/dg4Odq4uFhIWBnRmVhe9/Axi4i0TUsSDA1mc7Jj0jVh0DdksrDnsnNid3JicPS47u9m7uvq4uXl7eDg6OZ0xNmO0cZAIDDFPSDaMRQt7+iIsrO0Sksp8g61pOb3OXo7TNkg2tUSpaHqdvawDaD2lFO/ffitoDg0Nubu7FxYWtrS01NTUlJaWwpl76rU3igtsampqbGz8QKkFHvJYdPRpb2oAMQmn2Ljvvv8e/uyrr75KS0sbHR09PDzEYDANDQ3UE1pff/tt4+CQXgCS8aY6kFWk0zMScHT7xA8ph4rjs7Rl1NT9M72QkLGJjPrxp+OFaf7+978nJibi8fh79+7Bydjh4WGIP7iHTD2Wc+/e5zExvRYWZSkp+P9OKff58+epqam0tLQ0NDQWFhby8vIAAG1t7f+h9unHG9q+TB34u/DmB/O3JvAQtK/GMhppclhYI4zMpt5hk3358mVqaqqWlpa5ubm1tbW9vbWTg9Un0kgajUARf0+jOLR5QrIo0kfYJFhY2R1IX6GXl2PR0mM1sWC3sed0dGVy9uB2dtd3dbN3dDxtZMpi5yQdFGqRkKwfHX/Ryxdha6Zubx0moWxPfypYTDbRyCzByCxUStGBTUALMOT4B//09i17/fp1WFhYaGhoeno6nL8vLS2lrH0cCcF1dXUNDQ09PT0nf7EA+jwgq8CsqFLT00v9s83NzdTU1KWlpYODg/b29pqammMbfwefPky7VSth7wTklICSKpe1A5eZFbO2Pp26FpCQ8YyNP+Htnzx5EhcXNzIyAp0rBXww+HZ3dw8NDX1kPP2gffvttxcvXqShodHT0zMzM2NmZhYSEmr4iG7m/6Ll+NXfBD7Op3OR/C1oHoLR5VRGAw0OC2ugZzTwHmaxlpYWQ0NDCwsjOzuzc+fSAJgTEjow8ukzS465FOihqJ2YL71Wdn3bWCSBQUIcyIoxq2qwGpiwWdpw2DuzObuzu3hw2dhzOjjLB4dbJKbooOLOennSWZnL3fDx4VZzO8WDUtZINrWK1TYIuHzDFLCacJ0Z6TiGYI9EIrm6uiYmJmZnZ2dmZlKvXcKRVegCIf5gFJ6dnT352wBMWrpAXFLKznHjnZQQi8WWl5dvb29vb283NDRUVlZSVsjetX///vvU6qpvWjqHmiZQVgVySkzKqr7RMY+Okw6kGAV8MOxC8FGcHwaDaWtrW19fP/kaPtKePn1KQ0MDADA1NXVzc4PJyvj4+P/KH/9Iu5Xcqwy8HE9nBfE3o0/jLYVymPTUOcytEPrGGR3v5S5fWprz83M/cyYNgLnLl+8YGTw30P77OctMFf34SuXdNueHt4zvFp7dCT7fceG6AZC+zKCoyKKjz2pmyW7jwOHoyuLsftbT1zwhWQsVe9rLhd3E2uRiWtKpsdwbS+kGYQmm+pFKGh78wtqANlBV59FxXPL/+te/oqOjg4ODMzIysrOzs7KyKGu/cPKe4gUpEKyrq/sgOwUA1yX80tJ/fmdg/+uvvy4sLCQSiXt7eyQSqbq6ury8/INZ5E8vX/oHBnpGorzjE+paW4cHMSdoyJDJ5EePHiUlJU1MTOzv7+PxeEhsRe38+vv7Ozs7X/yPy28YDEZWVpafn9/ExCQyMjIgIEBSUtLZ2fnHH3/8/fff8Xj8kaWk77//fmpq6uOX7z/SustHlIGnA09GIH9j3OlhxwslzNoaHGaWrJa2bLaOirHoxPau+Tv7P/98NFopK/cBMHHlyr6x8VN9g89On91RPj9ea7jd5vywyngv/epMwpmx3DNrGWfmNS6H00peQ8jdYFbXYjUyZbOy5bB35nR2l0CGnPZ2vqTu6c17K0NgpvjmZpPTZ3V2B+GS+rbMXNqAqTQq7l/vGciYnp52cXGBHefMzMysrKzc3Ny8N1ZYWFhWVgaTD+jz6uvru7u7T2YKJJPJoH4Ac+wP+vr6bt26tbW1tbKy0tjYWF5eXlpa+kGmn7GxsYjwcExv78rCwuT4eH9//8kKlPPz8xkZGcvLy1tbW5BtF4fDHcFfV1cXiUT6T0UKjpiUlBQAQFBQMC0tjYmJiZGRMSsri0wm//LLL4aGhiIiIpcvXy4p+bOscHBwcO3aNVFRUQ0Njf9dfn1Cy6wS8LDjTgvgr485PeR5/ha7lja7iRmblR2HgwujvQuwsKW3c7gSiHLx3WxpevH06at//OOllhYBgLFr1w5MTJ7q6n3Gc2ZD+/x8k/lBq/OnpVqbyZcmQng6w3i74s+MpJ2bKxDY8rvUwH9dE8h8wqikwqJryGZmxWxny+xiqygTFc3Vny2yWGm41+x6v9psL0d81wm4mfHzTg/j3/eZodBSUFBQenp6Tk5OWlpaenp6WlpaZmZmUVFRfX09BoOZmpqanJwcGxsbf2NEInF9ff3Zs2cnHPvAsa8+efIkNzd3amrq9u3bQ0NDFRUV1dXVxcXFn57IkgQ5YrOzswcGBkgkUl9f39jY2Mk3o7Ozs6ysbHt7e2lpqb+/H4/HU8B3JPj+11TjP/74Y0VFBSzmGRoaNjU1wYAbERFBJpMXFhbU1NTIZPLt27fPnz8PXR3c3yGTyU5OTun/q33eReKWCvC0OZXsz18XdXogULBNzjNA3NvnlJ0ju60jp4PLKWf3Uy6eLB7W4EoZAPtsbDu8vEsATIiJHZiaPtPVfczNv64ntNjpcLfZ8V6B0mocP9GFvsyUNdqNpzCYty1GAJt0bjxPYCOJe1r2TAD45CoQFwfKyqwa1kaCeUnsY/kS67XWB03Oh6XaW4mC426gPsmo/PlnJ4lMTU5Ouri4oNHonJycjIwMOCxdU1PT398/NTW1srKyuro6Pz8/NjZGJBJHRkYIBAIOh8NisXCkdHh4+JtvviGTyd999x3suVPsePA1Nja2tLTs7OwsLCzU1dVB8JWXl58cQw8ODkJCQhoaGiCG6uvrT57i/+OPP4qKitrb2+/cuTM5OTkwMAD/x3edH1xL+f5NGv4fWVhYGKwnZ2dn19TUWFpaGhsbJycnw3bwr7/+Cn0zbFjBOnNAQICnp+fz58/NzMx8fX3/izd9n91eO9Rg8LbiSvDjvxV5ui9UsFsXGX09IIDJzJJJV5/V1ILN0pbd1oHTzYpDNY+Fbp+RcZuWdpeObk9c/IG+/mPO06sql5Z6XQ7rrfazbiyEsw0GflIZ7Zqlze2hhvCxP5Xuz1sXfqo/5jQ+R2Hslg8xNa0wLjMNlZOZjmyoMCNVWC42OO9Xm+xnXV+OYB9yZSzryBw9ubD+/Plzb2/v0NBQyLARHx+fk5ODw+G2trbW1tYWFhYmJiaIRCIejycQCAQCgeI+KI6jq6sLi8Xi8fje3t7p6ekHDx5QivnHgO/27dt5eXnz8/O7u7t9fX1lZWXV1dWQQuEIco9YXV0dGo3u6ekZGRnp7+9vb28/+cz09ddfp6amEgiE/f19AoEAZTYpRu384IreBye837Wff/7ZxsYGurqGhgYuLi4aGpqbN48KjAcGBl6/fp0y8/3dd985OjrKy8uzs7Oj0ej/9E1PsMf3nuuw+VtwxPvwV0dy94Vc6VAODuVxcTnrYMaocAOIXwfySow6umxWBnTnqhBgmp5+holpkZl57dSpbR6elfMXV52snpQa3c4Qmfanb3cUSgoLjejHd/V3DXmoxCkAZ2OGGM/zBbnRlV0D7fiJwZnpyYXZ2YWZmdm5ifF5Iml8BDdI6iodzTLEhN+o3Vv8ANvfv/71r7i4OA8Pj4iIiPj4+Pj4eCjXtr+/v7a2RiQSCQTCyNt2LAQhGPr7+7e2tqiVgo6C7/fff6+srOzt7d3b25uZmampqYFur6Kioq2t7QSSsm+//TYiIqKiogKLxRIIhObm5hNE26Dt7u6mpKRAUnZYXn4XfJQL6Ovrw+Px/1FZZHt7W0REhI+Pz9jYeGho6Pnz58LCwgAAExMTygnyqs/TAQAAIABJREFU119/DQkJuXr1KgwNcFtieXm5paXl2bNnUlJSra2tH/+OH7RvX3xnLIA0YY3y4a2KYR101SkTCvJgM7Yt8SM1ZhP9o1KVnC3PaMoAASMAkgEoA6AFgD4AhgAgnD+/YmHxREzuUJFryoemsjt9Zu/utpevR35e/ugE6c7dvdyIGm0+j9iIhF5sJ5FEHB0dpeAAeqYR4ghpbGR8hkiaxBNHRz579vDkOlxDQ4OTk1NYWFhgYKC/v39JScnMzAxk3sbj8ZBQhWIfhODAwEBHR0drayslHh4F3+joaFVV1fLy8s7OTmdnZ2lpKawflpaWvm9UE1p3d3dcXFx7e/vIyAgWi21sbPxgiorD4fLy8tbX19fX1/v7+yHUjnV+WCwWg8EMDAz8R0tueXl50OcVFBSMjY1duHBBXV29u7ubequlv78fACAhIaGhoWFmZmZvb29pabm1tSUuLn79+nUbG5v/rSojtOeP/2bCHWHJHO/JW+ahUKkSFM7ibqWqklLAtVNwbrNB6cDX/MDTZ97LY8DcvODUqSAAggBIZGKqFxZeNDR8fOPGPgDjbPT1051/Nirz8/KDg4Obm5unpqcePLqfk5ubV5CDHcKOj4/DBR84eAcHnLq6unp7ezEYzPDwMJ6AGxwcHB0dffDgwbHJ3MLCgoODA2RnhCosy8vLd+7cmZqawuFwR5D3LgQp+IMQhPiDTeGlpT8Fyd4C3/T0dHl5+eTk5OLiIh6Pr6yspBSvS0pKJt/P0vD06VMUClVTUwNDZ1tbG0XJ+ASDDZm9vb25ubn+/n6INtzbdsT5fTz32+DgoIGBASsrq4iIyP3791VVVQEANDQ0R+Ysvvvuu729vc3NTZhxv3z5Ep4Ff/jhh+3t7Y98r4+3fN9WL1DrcKPiuqO3BirsEz8fdgu7cCFM9oWljEsLRYILhqwbAHFPgP+BquqnvLyjbGyDUlJLJiaPDA2fCAvvAoAVutS6tv6E8gcPDw9dXFxycnL6+vrm5uaSU5KrqqrwePzU1NTY2Fh9U21iWlxsEgqdEpOckpSZmVVSUlJTU9PU1NTZ2TkwMACPZXNzc0folL/44gtvb2/IVRccHNzY2AjJx0ZHRyHyoJ2MvyMuEIvFtre3YzAYCgXRX+BbWFgoKysbHx9fWlrCYDDFxcXQ7UErKio6odhbVlaWnp4OuZfhMfFklV4ymfzLL79kZ2f39/dD9Q4K+I51fhB/cCnpY7QVHj9+DACgp6fX0tL65ZdfJicnlZWV2dnZNTQ03iec/v/B7u0+tGFMR53FXLUKlAn1uxkcxu5qJyUXGsPVj+LHxJ7BZ50nWfHPM3Ftc3HtMjLuMjAc8PHdNzf/XFPz4ZkzGwD06On1/f3vR0m38/LyfHx86urqurq6kEhkVVUVDoebmZkZnxwPcIg0FHd2vhnmrI10d/F2dXOBAhaJiYmFhYW3bt3q6OjAYDAYDAaHw1Fu2b179yCDSlhYmJ+fX3p6+vT09M7ODh6PHx4ehniiRtjHuEACgTA8PNzW1jYwMEA5j/0Jvo2NjbKystHR0aWlJSwWC5dWKisrYcG6qqqquLj4fSPRa2trERERjY2N0D/V1tYODQ198E7s7u6mpaWNjY2trKxgMJjBwcFhKjvW+UG3+s1HqKiPjo7CZoabm1tvby8AgIODIz8//4P/4/+l/YE2qw6gaTZSzrvg7aQdhrri489gZK7E7KENgs3okjw4S8J5G0QYBwHNOCPjLBvbEifnOjf3zvXr+zw8ywC0+fsTyeRjHrwvv/zSw8MjOTkZKk9XV1ePjIwsLi1OTI/5SuR6c9dG8+O86dr7Ouc//+IZBoOJjIy0tLR0dnaOi4srLCyEqIUQPDg4mJqacnJy8vT0DA8PhwEXit3Dzjs8PlJy2493gUQicWBgoKura2hoiMKIAMhk8t7eXnFxMZFIXF5exuFwpaWl+fn5cHWKAr7y8nIK4wm1ff/99ykpKYWFhX19fTgcrqurq7Ky8mMaErADuLCwQCAQOjo6ILxOAN/w8DCMESevBfz++++urq6nTp26fPlydnY2mUyuqamBJ7/CwsKPwcj/kS2RtmxAVrBQ9zkbVwVk0M3gcFoTi5CSio2J3XJ0m69akh63Hx/wBSAWgCIAWgDoRyDwdHRjDAyTALTR0rY+efLeUsPw8LCLi0tubi4SiSwpKcFisQsLC3NL0/EGdcHnOmLODLmx180u/sVxs7a2FhUVZW5u7u3tnZiYWF5e3traCov8dXV1ISEhPj4+kBE5Jydnfn5+bW0NnhThrTkWfydDkEQidXd3YzAYAoFAOc+Aw8NDuG+xtLREIBDKysry8vIgQxsFfJWVlbW1tcdun9fW1mZmZnZ1deFwuMHBwcrKyg+2k8lk8tOnT1NSUggEAlQs6u3txb6xDzq/lZWVE6Y+X79+TU9PT0dHd+bMmd9//72wsNDe3t7GxiY0NPT/pxD1UXLzP35HyheGMHaqqKMveDlph6GE3b25rO3+RqU6/vSzr5rb593cbgkKRgOABCAWgSigpx9AIIbp6AY4OKa++uq9davff/89Pj4eiUT6+/tnZWX19/fPzMwsbc7l+7cH8bfH8mKd+avW3iGzJxKJcNsyKioqPz+/vr6+p6cHbl2lpqba29sHBgbCc/bIyAgctaTcoP8IgvBF6PYIBAKlXwBqamogox6RSKyoqDgyKgPBV15efmydZXR0NCEhAa40Dw8PNzc319fXn9xPg9bd3V1SUjI3Nzc2Ntbe3j44ODg0NDQ0NHQy/mAtZmZm5qf3DGjt7u6amJicOnXqzJkzkGgHJhmhoaEf/Ej/Q3v16tWXX365s7MDR2LhIz49Pb28vHxweLulEOMMir2vNPPY2SkFBd8MDkcYmSc0NR/7p/D4LQB82Nhyzp7tZmefoKUl0NKOiYjM/PrrSWT8h4eHcEUoISGho6NjdHR0aW2uKR8TLNAZy421FSm5//Ux07L37t2Da4dBQUEZGRlQHwaPx09MTGRmZubk5CwvLy8vL0OmZXibqPFHKeJ8jAvs7OyEeP38889/++23zz//HGCxWFikrq6uzs7Opp5QoICvpKQEgznaAr537158fDzcXMfj8V1dXQUFBYcnzrBA++c//5meno7BYBYXF/v7++EDQbmwk8GHx+NnZmbexwBiZmYG9zm6u7vJZPLU1BQtLS0AIDo6+shvHltcOFJV+eWXX16/fv3q1av3Odpff/314OBgYmKiu7u7urq6oKAgKysrIyMjLy+PMu5RXlmWX5BnzRsfdWpAXCf0opezdhhKxMOHw8Jm+86d77///pdffjny96urZwAI4+VtExQkMjGN0dMSAZhVkj86BP6utbW1mZqahoaG3rp1C4fDzS/MjuBHY8R6olmxljL5YxuzB/t/2fr6eltbGxqNDggIgN0df3//5OTkysrKjo4OHA5XUVHR29sLRVn7+voGBgbg0fzIbfp4F9jZ2QlfHBoaam9vr6ysBCMjIy0tLbm5udnZ2ZSv7Aj4CgsLj7AF/uMf/8jMzCwrK+vv7ycQCP39/UVFRSfUYqiNSCRC2eqpqSlY+KZc1QfxB93JsTnH+vq6jo4OBN/Dhw+zsrJu3LhhbGwMuzpIJBL+2t7enra29s8///zs2TNtbW3KkkFwcLCEhISsrCxUOE5NTb1x44aGhoa0tDSkKSeTyWtraw4ODmQy+Y8//tje3q6srMx4Y+np6ampqUlJSZBIgMIElZKV6KmL8qdvcLxRyelgpRIUohIczmRpa4GKHu7v6+jo6OvrGx4eHhsbW1xc3NnZefr0katrLQAxAgLtZ8+O0NNOMnF3AtEMR1T/B7/Y3377LSMjw9bWtqCgADbW51Yni5wHI2iG9ZUT/aODolCoyMhIFAoVEhICA66Xl1dAQEBgYCBUDfb29o6Nja2srCwrKystLV1bW5ufn4eS9/39/RT8HYEgxQX+Wcp+B38kEgmLxXZ2dk5MTIyMjMCZv/r6elBdXZ2YmAiTBmrwUSYEYamPuq/69ddfFxcXV1RUwFGAwcHBqqqqtra2jxk8efnyZU5OTmdn59LSEiT7gEGKcknUjv0I/iD4ZmZm3qXob29vh9vgYWFhjx49+uOPPxAIBB0d3aVLl8hk8tDQEJweuHPnjoCAQHt7+87ODhwsXVhYIJPJFRUV4uLiu7u7PT09oqKiL168MDU1raioODw8/OqrrygHifDwcAAAJKVLSkrKzMyEFK4xMTEoFCoiIiIsLAyJRHp5ebm7u/v4+AQiAzxcvey4UqP5MUIGPkKertphqMuevlzW9vUtLQTccF9/f09PT1dXFyz9t7S09Pa2Xr8eA0D6uXPdAgIkGjDLLpZN56jhVZDx2cOHjx8//vzzz7/66qtvv/322Or3q1evIiIiIiMj6+vrsVjs9NwkfmA05uygvHKYe5CHv9+fBlfH4Tq6n58fpD2Aq3Genp4oFAqFQrW1ta2ursJ5cthbh/ijdoFHovD7XODo6GhXV1dfX9/KygqBQIBrbxUVFQCNRmdlZRUWFr5vNrCoqGhkZIRyeS9evIDzWwMDA0QiETYzysvLT5gz/fHHH58/f76zs7O8vFxZWZmdnT01NTU3NwcZVamvB9rY2Njk5CQc0aH03CYnJ6enp6enp+fm5t4FX0xMDKWBSyaTh4eHhYSEmJiY3NzcyGRyf3+/vb39p59+euXKFcgV+Y9//OPOnTsmJiZwmFRNTY3i3mAvTkdHR1RUVF1dPTAwEL7dTz/9JC4ufuXKlZs3bxYWFubm5qanp0dFRUH+ABcXFysrK319fVVVVTk5OWlpaXl5eRVNBQNh9zC2TlOZfA5Hy5vIUBVkGKuNg5avf2t9fVtbG6wGw0FGLBaLww0PDg4ICEQDkCco2Hf69CgCTJ9SRDPYmjqiEzBdXdSLYRgMZmVl5csvvzxyFh8bG7O1tc3JyWlvb8cOYSdmSU3Zw1J6PvYu9pDq2dvbG4IP0h5AnXN7e3tIEAUhGBUVBRtobW1t1Kx7FAh+jAukQJBIJLa2tuLx+NXV1YGBgby8vMzMzISEBEDhQz0WfBUVFUVFRRQlmq+//rqsrKykpKS/v39kZASLxTY1NWVnZ79b/vj5558fP368ubk5NTUFP8fU1NTIyEhycnJzczP8xtva2iCFLzX+RkZG0tLS1NXVNTQ0srKyRkdHh4eHx8fH0Wi0kpKSu7v7+Pg4NdBfvnzp6+srLi4uLCzi5eVCJr+KjQ2Ao3tY7J9dFjwef+3aNV5eXlNTU+oPaWJiAvVkZGRkKKsuzs7O5eXl8fHxvb29a2trzs7OFhYW33zzTVhYmKSkZHJy8uXLl5OTk5OTk8PDwx0cHNTV1RUVFWVkZCQlJSUkJCQlJaWkpKSkpCSkxSREZe3ZshLOEq5o+V50d9QKixT19uc0t/Ly84+LicnMzITK7TMzM0QiEY/Hj40R29r7GJkiGRhKLlwYPHVqDAHGTuuE0lubRhYUTpKIg4ODsM0I5S4gH8rIyMju7i7lgXz16lVMbFRQUGBxcXFLS8sgZpA0MVJcU5WWlp6dne3l5QXZjiEFHmUvjsKFZ2FhYWVllZ2dDeeM2traqIn3KPijhuAHXSAej4eUamtra5WVlR4eHq6urt7e3gCSoebl5RUUFFD4yCngKykpaWlpgfH0/v37FRUVt27dgsiD6W1GRsaRlteLFy/W1tZwOByRSJyYmJifn19dXV1bW1tcXIR/f3h4uL+/v66urrOz88jDNDw83NPTc/HiRTc3N29v70uXLnV2dk5NTZWWlvLz80N6excXl8PDQ8p8DQaDAQAwMDCEhvp/+y0ZhbrLzp7LxKQEAJibm4W/QyKRGBkZq6urVVRU2tvbKR/V2Nh4YmKCTCYrKipSrsLa2rqxsZH6iqSlpSMjI69cuXLx4kVVVVU+Pj4bGxsPDw94IpSWlpaVlZV722RlZaXkb+id8UKeas+9MW+kncpjqSfi7M5l78xlaaOho2NnaxsQEJCSktLY2DgyMjIzMzM6Ojo9PVZV3oYA4Yxs1fyCw3Ssk4AWz2fuw2hlkVVdMz0+RmmVUidhAwMDUIlldnb28y++IJPJPe0YaxubSFRkYWFhc3NzV1cXDjtEJBLHx8fr6uog84uLi4utrS3cS3dwcPD09AwJCUGj0SUlJVA9AZ7IKdyPFOK9d13gyYnIyMjI4OAglEabn58vLCwsLS0dHx9/+vQpgJtI7wNffn4+LAkuLCwUFRW1tLQQCISxsTGIvMzMTMqY07///e+nT59OT08PDQ3BKdR79+4tLy+Pj49jMJimpiZ4Koe16IaGBrjddORKYJ9DVVUVKgxKS0tjsdjZ2VlbW1sTE5P9/f3i4uKrV6/C0Hz37t3V1VVHR0cAAAIBIiLiLl3qBYB07dqXDAyb7u7Fv//+5xh3X1+fvr4+mUxeXV3l5+enUEAbGxvDcVdnZ+eEhAT4ooSERHt7e2ZmJvzPoaGh8+fP+/r6XrhwwdjYWFdXV1RUVEhISEFBASpeQ5OnMjl5WSnl67LXbrpwFMZcGCrUXM64OSkgb0Kvq81qbs3i6HpRXUNGXFxVVdXV1RWNRsNq18zMzMLybElyjQoNUk+gSk94UIVzTIG384ydM7OVTWVr28zExPs6V7B5NTw8vDI3V9zTJnHVzVbB0yvQDYVC5eXlV1VVNTc39/X1wUA5MjKyurq6u7t7+/ZtqM/92Wef/fOf/6T0Levq6pqbm0kkUmNj4xHuqf/UBeJwuJGREYhaqFhEvY54EvjgJN9nn31GJBKLioq6u7vh0zM8PNzU1JSZmQlVCV+9erW/v08ikXA43OLi4sHBAYTFwMBAdnZ2aGioi4uLubl5eHg4DPydnZ01NTVHrgReBpz9kpKSkpaWVlNTU1JSgq1AfX19b2/vxcXF1tZWUVFRSIHV3d3NwsLCwMAgKiq6u7uZnk4EII2Tc0JW9s6FC596ePxVv+3s7KTM8BUXF4uLi8NKoaqqKjzO3r59W0RExM3NTUFBwdLS8ttvv1VXV7exsfH29mZmZnZ1dTUyMlJXV4cc+XJycqdPn5aRkVFSUqIwriooKMgrysooSUgricvLK2hJmDnzZUXw9KVKjxXpLRdeWTMUSgIa8qwm5qy2jqctbeRkZaUkJeXl5e3t7aOjo8vKyjAYzMrGYkZImR4IDr5UnXClL50P73+1+pSDHa+DMwaLnZ6cHKUyEpURicRREmlpZgaVnQOMDYQV3GyZE910w3yQ7mHhoXFx8YWFhQ0NDe3t7fCrhlX9ycnJtbW1/f39Bw8ebG1tzczMrK2tLS8vp6WlwfFKyIBGwd8JEDzBBRIIhLa2tsHBwYWFhcnJSerW/F/go5YBKS0tLS0tLS4urq6uhu89NDREIpEgAXl1dXVqaipE3s7OztDQEJFI3NjYODw83N/fn5mZaWxsjI2NdXJyguoxRkZGbm5uVVVVsEVBmaqAl0F9DUQiMSEh4erVqwsLC2tra5cvX46Ojt7Z2XFycjIxMbl9+3ZhYeGVK1dKSkqqqqoyMjLo6ekhXQuZTC4snAAglI6u7+LFVUXFTzk5b+/t/Rmanz9/Tr2l1tvbC6P22NgYpWd47969rKysuro6OAD74MEDqHWDQqHa29uRSKSNjY2GhgbUFxYTE1NQULh586ayirKiirzcTUlZFUkVOTVDcWcXobSIs12pZ+byLm3mi20Uaa7lqiyk8I/fFApBqMiw6BuxWdqwOrhcV9dQkpWRkZGRlZU1MzMLCgrKy8vDEYeiLLJMQFTQpfroTwYSeEZsxAvZnKy4bR0bu3s2l5YmJybG37axsbGxsbHJiYmVuTlkegbQNz7j7qkdGe1wMQN5tsVfJ8XDz9XHzysyMjI1NbWgoKCmpqa5uRme5CCvKKRWqaurq66urqurg8psMObW19cfS392BH8nJCLDw8MYDKa2tnZmZmZpaYkyTHU8+CgFl7Kysrq6up6eHpiRzczMwLWMoqKiwsLChw8ffvHFF/D8sbOz8+DBg52dHQKBUFRUFBQUZGNjA0+1tra2cOE+MzMTBtympqaamhrKY3TkGcLhcGVlZUJCQoGBgUgkEh7+dHR08vPzhYSEkEjklStX7OzsIiIipKSkeHl5BQQENDQ0Kisr79zZ3dv7lI0NBUAFJ+eknNwBH99df///kuzs0aNH0Ou3t7e3trbm5OS4ubmpq6tDMisNDQ0tbU01LRVlLTkVdSUtRUNLcX/vS0UxZ4Yyzi4XCO8W39grVdgrU90rU90rVtxOvzwbwFfHdUOBTl6ORVOHzdSSxd75rKmZsry0nJyclJSUjIyMq6trMDKoMD/bRAOpfD7MX7QOfR6XzD5qYZLN6+nEaGV32tUzqaZ2fXFxYXZ2ksomJiZmpqdXF+a9kpKBnpGgu7dBDNo0I9FUIznsXFv0WSzykxp/9xAvX09fX9/Q0FC4eFtYWAiP73C7u7Gxsa6uDv4nGo2ura0dHx+HS2jHMqB1dHSc4AKpozAOh2ttbW1oaNjb21teXj6yVgGys7Nz3lh+fn5xcTGctBkcHCQQCJOTk7Ozs5OTk8PDw21tbbm5uQ0NDQ8fPlxcXITSzg8ePIBbj7m5ud7e3pBYBKbuMJmytLSERSM8Ht/d3V1ZWQkrBfAxor4AmPnicLjU1FQlJSU5ObnMzMzq6mpzc3MCgZCWliYrK+vn5zcwMKCiogIpL3h5eTMyMmAYunNn3dy8CIA4BgaMiMi6rOynAgJ3Pv/8w72+I7a/v5+SkgL3sm7dupWYmGhqaqqurq6rq6uro6ulp6Gur6yppWmkZOtwPTroQi36DCn73Hrh5b0Sqb0y5b0ytb3SmzuF8ps54svpIrMJ50gxfMPRZ3pFJDQRMpLMKmqshiZs1nYcdk5SihoKcjKGhobFxcU//PD3sZnhy2b6TLZ2Aj5e6oGxLnal1saFV3wDuZ1c2G0dme2dEdYOJokpY+Pjm8vLsOo0NTW1MDe3trhgGx0D9IyEvPyM4hKsElNEQrwUNKIiBTtQZwdQp4YKE2pyCjIjIiJ8fHwoUj+QxhkuoUHvk5OTk56eHh0dDaeHYEOfmn7lZBdILT9JicJYLLampgaDwRweHsKn5f79+y9evIAT1CAjIyMnJ6e4uLiqqqqpqQlmspOTk/Pz83Nzc5OTk3g8vqOjIy8vLykpqa2tbWVlBY/Hz87OHh4eHh4ezs7OFhUVeXp62traOjg4UFidIZ+9tbV1cHAwLM1gsVg4yQKJVCnP0LvBFw5BwGMN7DPCHsDExMSjR4+qqqoEBASYmZlpaWl5eHgCAgIgoczS0kxdXS8AwQDUcnNPKyjc5eI6SE7+AEXzEfviiy9ycnKg1HZFRUVYWBgkPTcwMDAwMNAz0jFWtXW7mhp2rj1ZYDpXcKvoyl6JzF6Zyl6Z2l6JynaBzHrWtcVUoWn0WRKKdzCQp9GDuzSYtzWFd9r2kwQaOVFGRQUWPS12B30auQzRT/KTk8L293fJZDJu+Pk1lUEGrahrwb7aUXE6cbESEUE8vi5MltYsekasJubsNg4cDi7A2v6Sb0BlZ9fu2ur83NzS4uLy/LxhaBgwMPnEx98kPtEiIUXY31PECplvuVyisxIlMBQnjBnqxxcW52dmZkKueqjz4e3tHRQUFBISQuEHR6FQQUFB0dHR0NFUVFS8j4Hq5ChMjb++vr7KysqZmZm7d++SSKTNzc2VlZXZ2Vko0wIaGxuhRuX4+PjExMTs7OzCwsL8/DyEXXd3d1FRUVxcXFNTE2QUIJFIt2/ffvDgwdraWmNjY3BwsL29vbOzM0UoFrLHOTg42NjYBAYGFhUVwQcITsrAa6BcwLHB99gECp4s79+/b2VlBalwz58/Lysrq6OjExgYmJ2d3d3dtbIyIy+fDEAKIyNWVHRLUvJTYeH9719+LK3LDz/8UFxcXFdXRyKR4DlPT0/P0NDQ2NjY2NjYyEzfQMnKl6s28+JKheJBqfxemepemdpusdJWntRa5pWF5AuT8QIjEdz9fhyNTly5plwoPfZAS874gNMNMXzDcecHzlzXo7mhxCRnxHAlAYBRAb4ZMvnXH3/8zclpCYARDrY7CnLPDJDValGhl70DmB3tWC3M2dRVwDUxZjVNVkMTNktbTntnBjsnBjsnn/zC9eXlpdlZdf8gYGh61TfQDJ1kjk6+4OsubB1UbrvVYf+4WHUznBWbqNJ5cP9Oe0e7m5ubnZ2dnp4ejPUKCgoaGhpQz9bKygryr9nZ2SUlJXV3d8OBOorw8xEGoGPxBxnAqUUoMRgMnDXZ3t7e2trCYrErKyu7u7swJd3e3gazs7NLS0urq6vr6+tLS0vT09Nw7q+xsTE7OzsmJqa0tPTu3bv379/v6+uD0i4bGxsYDCY+Ph5CDRLrUqu0Ozk52dra+vn55efnw8+dm5ublZVFfYygTqOOBN93syc4yTc/P7+5uSkrKwsAYGRkFBERUVBQEBcXV1dX9/f3z8zMxGJ7s7ObAAhFIJp4eRYUpR+zMR9WlX54+JRMJv/xxx/Nzc1QQYRAIGRnZ5uYmJiamkLFV1NTU2NzQ/1z3n5c9ZkK03V2B6Wq2zniK+mX55LOj8fw4UK5ur3Za+y40k3OInWv22mr6qnLGOiw+JtxRnlwl4TxdaUJTOidTQUIHwCSAGhBADwCMYtE3j5/fhSAuStXDrW1n2irf3lDcYXPxQNY6fHftPESrikK75SyNwSilxnklVh0DVjNrDhsHdkcXICVvXpMvGpQMMLYXDwg2CIh2TQ+6Zy3q7BNUKXDTqvlp9mSi8FMff6XKjCduK3djYP9g4iICBEREUlJSWlpaRkZGSkpKVgVhyYpKSkmJqapqVlQUNDV1QVbrLC/eoQE7eNd4MDAQFVVVV9f37179+bn5+vq6uAEE5yW39nZAaurq4uLi9PT07D729HRUVpaGh8fHx2VkUfuAAAgAElEQVQdXV5eTklp29ra5ubmNjc3YcHPw8PDycnJw8PDw8MDcg9S8Ofs7Gxvb+/j45ObmwuddkFBATy9UbgUKA/QCcH3SOo0MjLS0NAgLCzMz8/PxcV14cIFKOMmIyMjLi6uoqLi7e2dkZExPDwgKhoHQB4L15CEZZ+kX718eOuvv500jAQNTyDk5uZisVgikVheXm5jYwPPr38KMFlZWlib6Z7xsOfMihbrSxEfTxQci+IZCuJod2cvs+ZOML7oqydto6tpqG+sa2ima2iib2Ckp8XvasAaancqLZC3KY4PH3Wxk5PVD4BoBKIQgehFIMYBGOPh2VFSeqyn91RZ+aHg+T1AN4lQs9XQRsUKDiVykXLPr9Z7TzmGBNNJXQXikiwa2qzGZuxWdpwOLvS2Tghrhyu+gVaJKcaxCQKeziI2yCrH3Ubjw7RPZvxo2yKUKokjpLXtldnZue3t7Y2NDWtr6+vXr0MdKFgJp5iMjMyNGzdMTU1hfaOgoIAyX/I+EjTqCHbEBcJb2dXVBVeCHjx4MDAw4O/vHxERkZmZCYVG+vr6AGwqNDU1lZeXZ2ZmolCojIyM4eFhClni1NQUnAPY2NiYmZnJzc2FYg+enp6enp4U/FHkOh0dHb28vLKzs+HkQlFRUXp6ellZGcWHU86w8KNTPvfJwXd9fd3f3x8AICAgcO7cOTU1NWoxN1j78PPz6+pqRIXXAGY/VmvfSzEhWnnpvFGo4Z1j+DF/evUqubPHorg8k0CaWlisKMgfxGCIJFJTU5O7uzsk46YoMdnZ2dk52piqOOgxBtuwprmxljuzF1jyxRiLehkqWRsaGBtbGJhaGZmaG5uYmBgbmxgbG5tYGOrKWOoyBZlzxnjxlKP4epLOjt8QykYgggBIRSCaEQgCDc20ouIDXd2nYmJ32TlWAcDwsVcHyLeXXN1AnxmJ5h9K5J9I5lio1V7PTLp1wVAFiIoyKquy6huxmVtz2DmxObqe8/LTj47n93AWsQ2qctit1T5IODfmSVeX7lS/uDa/sb22uLi4uLi4sLCwv78/NjampqYmKSn5Vz2cyqSkpBwdHZuamurq6ihTYdQkVNQu8IOnwJ6ensbGxtra2s3Nzb29PXj4S0xMhKohSCQyPj4e5OTkxMfHh4eHh4aG+vv7Y7FYSqP69evXGAymu7t7ZWVlY2NjYmIiPT0dCkV4eXl5vjFq5+fs7Ozj45ORkVFTU1NfX19SUpKWllZUVERhcaM8PUec35HgC2uhMG+HeXdYWJiYmBgdHR0DA8O1a9eUlZUp4JOVlZWWlr569aq+vn56WmpXR6+gngWdqRGPL1I+MU0MnWpUVv1ulHVISQcGZsDNB7j7cvgEeeUVEvD4oZ6e4GCkg6MjnDiiPsU6Ojo6uthbaDoZiroZ33A107a1tLKwdrSwcbC0tvlToQkqhJn9aabGJiY6pz3N2MI8eDJRfM2KjGOCl0icnCEAxCAQ5QgEBoDxy5f3Ll7cA7QTADRqnmvNlphJ4Z30Yq514c4LOF2P4h9AnyElcE4XXd6oixg18nMD1y/TSMmyaOuxmlqwW9tzObpxujpcsPEptdmoUt5DncJ5sFVWJXVu311f31hbfmNLS0vLy8v3799vbm6WkpKCvZm3ujJycrKysr6+vh0dHeXl5bD0cUR+nJqH731UzNTneEhaf/fu3YWFhcHBQZieEwiE9vb2oqKi+Ph4EBoaGhsbC2fRenvf4ufDYDCNjY3T09MLCwskEikxMdHV1dXLy8vb29vLy4uCP+j8oNsLCgpCo9FQqhpKq+fm5lIugBp/lOBLXT16N/j29/eTSKSGhgYAAB8fHz8/v6ysrIqKyrtKlpKSkpKSkl5eXh0tTT7xcUBJld3FUyQiVjMjjy8ibvnhW3RdD588pb2pwWRlz+7qxeEdwOofQusXci020Tkm3sfLJdDfDV7cEafu4uLi6uHs4uHo7OHg7Obg6PSna6TWqYORGr7o4GytJGZ/gz5UjiXhHEMjACSAmKWhiQIgBIAsBKKDhmaMiWkJgD5BttpgUWyu8LQPoilU/JazeJwscLDkQHvzVIbxdcWdwSfwTqRxLTVZr0fF5/BoygCpKzQ3FWn1tYGFrqCNd4H5Uqn0VjBzn59gRV/T8O372+vr66tv28rKytra2uHhYXp6+o0bN6h7MwoKCnJycoqKipGRkV1dXfn5+ZCHinrc5FgevvedAuGycG5uLh6Pv337NmwAwpL4+Pg4LBtPTk7+OdWSkpJSV1dHzYaxsbFRVVUFay6Dg4NRUVFwEgGa1xuD+IMD3GFhYUlJScnJySkpKbm5uampqRkZGfAC4KensPh+fPCFqQYKhYLNDB4eHihvSQHfkeCro6OTlppS39DIo63HYGbF6x+inJxxOSbJrfEt4oGKzi4gJsmsrc9iYsFm58Tu5s3pE8TkF8wQEnTZO9raPjYsxCsoyNPHx9fHxwde75EzBhTXg64RGnwFukwtLS01NbXLIpdO818CiCAA4gEoRyAwNDQLCEQLAN4AxCIQDQAQAWhnPTXgcGkmnq3fhbW4Knzgu39+9/LlyxSvCllgp8sQ7Mqdj+RtieYfTDgzlsAxU6OwnWDRdF3I7pKU+ScaTprmidkG8wVX1nxpWyOVqqcmpu/c311/29be2Orq6vb29sHBgbu7u4yMzM2bN1VUVJSVlWEYUVdXT0lJ6ejogOOx7yqQf7wLbG9vhwPwi4uLGxsbAwMDsJZypD0D0tLSkpKS8Hg89XDiV199VVFRMTIysri4ODo6ikKh4JgrtVHA5+7u7u3tHRUVBWGHRqODg4ODgoJSUlJgBZvy6amdH3V5/X3Bt7+/f3BwUEZGhpmZWVRU1NDQELo96qbqWzK+UlISEhJubm4t9fWWQcHgpjqHm7coKl49I/d8dML9v/21fafp4w+k5JhuajCrazHrGrCaWbHZu3L4erJZJgH2CQTt0rWrHe7uMVFR3sHBfnAMBM5gQix6e3t7enrCf/j6+vr5+bm7u5uamhoaGoqKigoLCzMxMUGy/HPnuAGQByAGgEwEoh2BINHQLPDydrKwJCAQcfT0JgIC4oCu6SxoyzSsO9h4izyF0DGjc9pLGXjYnUr1PV0Twdcbf2Yk8fRUKtdC7qWVOrO7rU6f1uvcTT0/40Fbm+7YsLGzevvu7saJtrq6+ujRo87OTiUlJdizUVNTU1NTU1ZWNjQ0hLMjiYmJUAE6MzMTNsA+0gVSytEwZWlqatre3p6ZmRkaGoKujroxMzExAbKyso4Ix79+/bqmpqa1tXVqamp0dDQuLo7a51GDDx7+AgIC4uLiUlJSkpOT4+LioLQXrJ5DIkuoXw1ZVN8XfCH+jmTsBAJhYGCAg4ODgYGBj4/PysoKPqZKSkrvw5+4uLimhkZmcnJjfQO3hhajmRV/QIhyUsYFFDq6/0+6j8fPnzMr3aRX1WBW02RSVmVQVqVRUWcxMGQ1s0ewNAJAQCDGAVhmYJhXUGgICkLFxfmHhSGRyGC4xwoLs2FhYXASU0NDQ0xMTFBQ8NSpUywsLOzs7FBei5GREQBASwtMTFxZWOIAiEMgqhCIIQAmJCQeaGl9ycnpxMQEeHjoBAVNMD33yeRjUvJnD7/wUI1VAM5m7NHuPMUhvG0xAthEgfH0C3O1FgfFqhtR3HhPtqqa5J79T3f2bu9ubm5ubW1tbW1tvsfW19d3dnb29/c9PT1VVFS0tbW1tLSgn7awsCgqKqqsrIyLi6MWgT7iAin38Vg2ZnhDoV4mFovd29vD4/EkEml2dnb6jU29MfDuju3y8nJMTMzQ0NDk5GR6erqjo+O7yIMGVazRaHRKSkpSUlJ0dHRAQAAcC4MqwrB7k52dDadm3g2+EH/wcaE+rnZ2dg4ODqanpyspKZ0/f15ERERfX19DQ0P5jVHwRx18ZWRlZaSkJG/ccPD2Sa2querly2DrxOEbxB0Yyo2MOB+d8OL778lkcm1fP7h+g1lDm1lDm1FN65SuwSVjM3BTgfaaHQA5AFQC0IlADAMwCcAqG9uUllZFZCQ6MREdFxfn6+vr7u4uJycnIyPDw8MjICCAQCAEBATgED8dHR3Uv7x+/bqkpGRnZ+ft23fIZLKxcRkAAQDkIBBdAJAEBDYEBA4ByAGAUUREiEAY/OXX97K/ffb0kZGcoxqzuw5DkMOpDP/T9ZF8/WgBUsaVuVDWAT/BCkzryOFnd3Z2trc+ztbX1x8+fNjS0qKmpqanp6enp6erq6ulpWVtbZ2ampqamhobG5uQkJCUlJSSkgKpICkukHr66YgLpNzQhoaG8vLyoqIiWJsbHBycmZmZfWMzVHYMRdrAwEB6ejoEbGhoKJzrPOLzfHx84OIJBF9SUlJkZCRFKzEmJgaqqKekpMCPTh18IYX+scGXcvjr7u4mkUgiIiIIBIKfn7+mpgaNRktLS1POKMc6PzlZWUkZGV5Ti9PICN7wGPbQKM7QKM4QFEcIiiM4Erj7FpLGyGSyfmAQkJJl1tBmVtcCSqq6YZG7W1umfh5MwmYARAAQB0AWADUAdCMQOACmmZkPhYRaVFQUlZQUuLm5OTg4mJiYoHuDqm40NDRcXFy8vLxiYmJubm45OTmVlZXUM7ajo7sAeAKQgEDUIRAjAJAAqDMzG9ze/pRIxAkKCgoLC6+tvXc/ra65xs812OITpDJwM2eP8+IpDzvd7UfXFqlYMz05e/hof/v99i74YO1jb2/P09NTS0vL0NAQCoja2trCMxhUuzyiQ/4+Fwi9CbULrKurg1vAm5ubs7Ozw8PDi4uLc28bBOIx4KuqqkpPT4d0RvA0Q8lwobfz8/ODsEMikcFvzM/PD/YKw8PDo6KioIp6UlISTDso2dPJwZfi/Hp6emJjY6FH4ebmrqioMDQ0VFRUVFFROQF/ijIyAiqqDK5ewqg4jcy8C3HJbEHhnEHhnIFhnAGhwNnT+datfzz7gVHIlEFbmVlTi1lDE6jeTKyovLu7m5ORFhaBkpYOBiAIgHAA0ADkAVDHwkJUULjHynqdg4ORnp6OhYWFiYkJAEBHR8fLy8vDwwM7VEFBQVDBFjJyHiEZ+uOPf6uqFgDgCUAKAOXXrjUODf0JzdDQMLh9cgIF6pMnT8IiQ5qaGqOdcm7Su6kCPzPaxEznpq29jf3D2xRUnQDBI7a5ufnw4cP6+nptbW3YPDQwMLCzs0tPT0ej0eHh4ZTtO4oLhBA8wQVSl6NzcnIwGMze3t7IyAhUvoU9W2qbm5s7Cr4//vgDhUIFBwfX1NR0dXWFh4fD8gqUaoWy5HDeCWLO398f/pTyChRSh8qwCQkJ7wbfoqKi92W+EH+Dg4M+Pj4wt9XX18fhcMnJyRISEkpKSrAuoERlf5UM5OXlZWU5VVSZre35AkKVkjJk0nI4kOHs7j7s7j4sTh5Ax6hiDN9QNQ+AG8M1O2Z1HXo1TVYl+/ZOzN7OdkZGRlIiOjMz0dc36pNPkAAgAYgAIJmPr1daeo2F5RorK2Bnp+fiOnXx4kVDQ0MrK6uEhIT4+Pi0tLS0tLSYmBg0Gg0v4eDg4F0AffPND9HRfaam5YWFo69f/8UyuL29LSoqKi0tPTk5+b5leDKZXFlZmZCIXlqbH+ogpiJL22v6b99765D3kUYB3507d7a2tjw8PAwMDMzMzAwNDe3s7DIyMuLj46EaL0WKnNoFwnM8dIHQmxxxgZWVlSUlJUVFRTMzM1tbW0NDQ/Pz84tvbOFtOwZ8ERERFhYWMTEx8M1iY2ORSCTcsfP19YX5BNTYhY4QghIa/FFYWBgc2qEOvvATHxt8qctF7e3tOBwO6kECAJBI5Pz8vK2tLZyl09HR0dTUpIzBwWFMygqFkpycgIISg54xh7vPlah4jcz887FJdMYWQEWNXllNzcvn9b9eKSrkABAIQCyCMRQwh4hdzyLgMXBAPzo6Go1Gp6UlpqWhHR0jz5wJBCCUiSmXjw/LydkNQJC6emRqaixFiyIpKSkpKSkxMTEmJiYnJ6enp6e9vZ2ybPXx9ttvv926dYuPj09RUfF9uvDPnj0LRgY3NTVt7mxs7a3fPtjd3Nrc2Nh4X2LxMaB8+PBhTU2NgYGBiYmJk5NTcHBwSkpKTEwMzKvgTYRB7CNdYElJSUVFBWRs3tjYWFhYwOFwKysrS1S2SGXHhN3t7W0TExNHR0cXFxcPDw8ooQ5xBj0cEon09fX18vKC8ReGYBiFIf5g8EWhUEeCLyVvf1/wbWlpqayslJCQOHfu3IULF6ysrBobG3Nzc2NjYyGbwq1bt9ra2uCAZ0REhKurq6mpqaamprKyspSUlIS4+HVpGUZVDRYbR/7AMJWUzKvJmeLIsIycnKra2jHicH/fGA1tIAARAEQBgAIg3twsCYfrOTg4qK6uRqFQkPwVjUZnZCSkpMRdvBgMQDwHRz039xQ9/f3r10eysmIT31hCQkJCQkJMTExVVRXcQT6WS+lj7ObNm/BhGxgYeN/vREdHw2X7hYUF2O2EZbwTCisnQHNjY2N/f391ddXZ2dnc3DwrKyshISExMTEqKgoen0JCQkJDQ9/nAqlPgdQusLS0FI1G19fXz8/P43A4uLG2/LZRgHg8IXh3d7eBgQEsnPq+MW9vb1hihYc/Pz8/uHVMwR+1/wsJCflPg29tbe3g4CASiYT83erq6nAi/9mzZ69fvz6WswJuBO/u7o6Pjzc2Nvr4+MhLS7GKS9AbmHB6+F2PTlBKy7mWlIElECZHR6emRszMUgDwAyAKgCgAwpiZkyIionp6Og4ODpqbmyMiIuKoLDMTracXDkAkK2s5NzeOjW2RnX0mMjI5OTmeglEUClVeXg7FkuBePfUW7atXr46wUlPXFn744Yevvvrqb3/72+vXr2dnZ4WEhAwMDLa3t48NvrOzs4GBgfHx8ZDSaW5ubu04W3+PHYvL5eXljY2NtLS04ODgvb29pqammJgYCD4YwSh1pQ+6QJiIFBQU5OXlodHo7u7uqakpDAazsLAAmytHDKLwePCRyeT6+npjY2M7Ozs3NzdPT09YzYf/hjmHn58fFF5/F3/UwTc6OvrdzBcqhxypvDQ1NeXm5mppaSFoEPT09EFBQc3NzR9PRQpv/MrSok9oGJBXZrFzPoOMUE3NFoxN9imrnCERp6YIGhopAAQBEAlACANDHA8PycCgYWCgfn//oKurKywsLCYmJvaNJSbG+fqiEIhQOrpcbu4+Lq5pGpo1O7vivLwEbW1tfX39lJSU1tbW8vJyHR2d169f//TTT2b/r7nvjmv62t8/CLIEFFAUFyoqSkVREARZsvdekRUI2YOEJKwwA2HvDbL3hrDCHm4Rd6216rV22Nven1Y7bq215vfHaT+NDIve297v8+ofIQXzST5P3uec93geJ6fKyt8MasvKyjQ0NA4cOFBaWioUCu/fv29oaHjgwAE9Pb1bt259//33R44c0dPT09fX19LSKi0t/eWXX8rLy9etW2dsbLxA/ffx48dpaWnFxcUUCqWhoeHs2bPT09Pw/i24qRcWYTmOzs3NwUWwra1taGgIXnBkZCQcg0du4ttDIMzFwBDI4/EyMjKSkpLi4uL6+vrGxsZ6enoWl/hEsSz5hEJhenq6paUl7E9GOllg2IOxEPIPiX8LFl9k37qSk295eXlBYb7sWikJWbBll0p2YTpsCFs580RhGoIFxubrgnFaEbF6ial7o+I7e3qmJoajo0sBIIqLx2/ceEpf/4Kd3T9VVD5MSGi9e/dyT08PjUZj/Q42mx0RwY6KYq1fTwYgbt26OiWlEXHxS7q6DRkZ0To6Oubm5pOTkxcvXmSz2RYWFk+ePDEwMBAXF4cSlNPT02pqajC0aGpqXrp0yd3dnUgkPnr0KC4uzsnJ6cGDB0ePHn38+PHTp0+vXr26d+/eu3fvwvEAAICoRMTr169PnTpVUlICS005OTkzMzPwtAjZc/ZNLFjjFkcdUSrMzMwgRktNTU3wlkHyiaYyFoRAuJtfHALT0tKgXQfsQh8YGFhcYhbF28j37bff+vv7u7i4wPU3ICAgKCgI8g/u/5D4Jxr8Fmz+YALiLYtvfkFucUV+RV1JQkKi2poPrNdj/VR5FZzumsZTKxEhXRL90zNAR0/W228rhWGcmLqFzaEVl00LhsfHB6ytuQCwNmxo0tI6Y2195/jxz3ftmpudPT87OwbjtCji49m6umQA2PLyJUpKAzKy51RUBLEczqFDB8hk8tzc3ODgYE9Pj7m5+YsXLz7++GMikRgXFycUCpOSkkJCQuDFUCgUAoFgZmYGR1ZfvHihr6/P5/Otra3hXuLJkycHDhyANmM7d+50cHCYm5tDRgyvX7+enJw8MjIyOTkZHh7O4XCGhobOnj07MTEhmrlYcJA88yaWIyiclICB9uzZs3B0fPEmCqEgEgLhhgqGQCQdnZyczGKx4MA5n88fGRmBBb33IZ9QKJydnbWyskIa5WEDAZLwQ4LfWxZfKpW61Mk3OS2Dl1WQllOUkZmenUwtYFsUk7ZXMDZ0xGwaSVe/Ei0/0591+f2YJxQKv/jsM6XjJhI2jooYgnZU3JH4lIOcxH4+XzA8yOd379jBAiBm06ZWbe3zjo73NTT+4eR0/dq12aioSBjzEMTGRnh7hwEQJiWVpaTUtXbtjAQ4z2SUo1Auqqqq+/fv19HR0dLSMjc3h69LpVJjY2OFQuHY2Ji6uvqVK1euXr26b98+V1dXW1tbpHru4uJSUVFx8OBBfX3948ePy8nJ6evrQ6eyn3/+mclkysvLe3l5wc0fTELdunWro6MDhUKFhYW1tbWdO3duYmJicnJStHgAIZrLXZBaW0BQuHxPTEzAvc3nn39OIBAoFMpy69hyIVB0FWYymTU1NZOTk3Cw/z8in1AoTE9Pt7a2RqFQcM8nuviK8m+Fi29cIicpLZabnpAYmxKDzmYal1C315Dlm6lyHeEq3eHbOigqDTFqw9ydZ3g7zv/z46V1+P4Ud27dsvT0AsdN5FCB26lMk6Q0VRYnprJqcnh4bGyorKxBSooiLp66fXufvv68k9OnW7bcCw+/kJsTD7c1CKKiIuj0cBkpqhhIUZRrV5Q5DTZ3xdb0UvDBhoaGs7Oz8/PzxcXFJiYm8HVhURs+bmpq0tDQOHz48I4dOxgMhq2tLSIraGZmVltba2ZmNjs7e+nSpcHBQR0dHUSsbe3atbBG9/jx42+//TY5ORkaI8bFxfn5+WGx2LKysjNnzszOzo6NjSF10slFQKpYb2En/IXZ2dlXr169fPkyMjISypsuvpUrCYFRUVERERHt7e0TExOwPHvu3Dm4vr8n+Z4+fern5+fi4oJCod5z8aVS6Cwai0OP4LAiaLFMj/Qw3WLK5lqyfCtNvoOh0snc3sna3cnW7CLsrkAppoaptCXsnohTmS2zvvzql/fx+5udmUmIj99iYydh56QUStSJTjgYl6wXnzwyOMDn86enhxmMQgDIsrKFu3ePmJjetLH6fPOm+yGhWbExDHZEhCj/4mIj9h3BgHWUdftSVOx5ckSqTW6Os519YmIifK2LFy8icggI+b766qvh4WGhUPjjjz8aGhry+XxjY2MoGHz16tWDBw9evnzZysoKuWBdXV34+0KhMC8vb9u2bSEhIQ8ePOjq6iouLr569erQ0BDMMKDR6JSUlP7+foFAANVwYLeSKET7RyZEsJid8MH4+Dj0E83JyVlyKVtJCIRn/4SEBDiMNjAwAPeUi88ZyNbzz8knfO/Fl0wkheHJ4TgSlUgOZFFsUigflJBV6iny7WFrO8M3djHVOll7Opn72xmaLTSNevKuap/1XOs1lBDlYpZqD1djJkp+ejjx7nuQj8/nlxUVEeMTgL6hvB96ZxjLJClNlRWTWls3OTzM5/OnpgZtbbkA0BUVq/bvOWNtfcecNKhOjWNEMGMi3kB8TIxzcAAwPr7O01kVH7yBTNsVnaBx+EhyQjx8rbGxsYMHD8LHQUFBTCYTkm/v3r04HM7GxsbCwuLVq1fV1dXq6up0On3btm3Z2dn/+te/Nm/eDNPa9vb2hw8fFhUxefLkiaenp5KSkrm5+eDg4O3bt9PT04ODg4lEYnBwMIvFqqmpgQ3eIyMjohoaI29CtHluOXaOj49PTU3Bce729vaQkBBYUFiOf285CFMolIyMDGg5yefzYT/VuUVY0WlXFKmpqVZWVqKLL8K/xSdfIolApGMJRALBh0kwSSbtLqEoN9LkO+hKXeGqXcydnay9Hcz9bQzNZureOsKOCvSmfC+5ZHuJCHNprMmaIBf5KOL66qitg9w9pzmK05/M/uvPr+9N1NXVlZWWjk9MqFjarHZwWY8l63ES93OSzLipE8ND/f39Q0MDAwM96uosAOJV91TpUdK8ijOOpWUeYUTEstmRIuSLiYoih4WtMTaVtXHYGBCyiUBbQ2IEJCTd+L16++jRI6QDHOZU4eNPP/2UxWKlpaUhebvh4eGwsDAoBPjzzz+np6fDm8fj8f71rzfe48OHDwEAMjIySkpKZ8+ePX/+PCxsksnk0NBQGo1WWVkJ9QCW06AVVXIRvIkF7BweHh4cHIRR+eLFi5DiMJv2riEQj8dzuVw4bdje3j4/Pw9Lussdd1ZKvidPnkClOmTxXZB5QRZfAhGPw+KxhkkktQqKYnOYQhdjfTdzSxdrVydLo4Op2Ubf30TZU4PbXha0MfekUrqHQrydPM1tD8XDMHRsYGqwYfooOOmzLoW2oTlu51jC1tOZB8/98OQdPKh++umn1NTUtra2ex995BfOAvrH5f3Q6owIY276FjansLFpfHi4j88fGxuqKG1eszlYytJpDxFrwknyyS3WTODZMFgJkW8Ev9joqL12jqtMLdZ7+23CkSWC8Zj6ZV3B/yt49eoVjUbbsGGDn5/f2NhYbW0tgUCgUqlUKhWPxxOJxJKSEsStrv9NDMcEBXcAACAASURBVLyJ5USSEV729fU1NDQMDAwIhcKvvvoKFkthvV50Q7WSXSAWi+VyuXD4pqqqanZ2Fh6MzizC2yocS2LJxRc29L6x+JIw3gfDiDItzA29zG1dLPVO1r4OpmYrfX8jeXc1dltJgHKWx5pE97WxDoo0HRnnDWDP8SOmaRm80anfNj0cv/xjIAitnB++sStp71TMupmWkBtvvzZRfPjhh/Hx8RMTEzduXKttrFM0s5B091mPpR7mxG7nxDin50wLBP39/X19/Knxkci0ZGBgsM7FU5MUZs1N88gt3hWdEMhkJ0T9UergxsU6BwYBQ+N1rp6bQvBKBOq28Mh/LSNK/q9bt+5mZX1VV/frn/lsvx2PHj1KTk4+duyYsrKysbExg8EICwuDxizQgw+KUSCSUAu0hBfIWS9H0MHBQT6fD7snYbYvNTUVrmkYDGbJPRXxdyzmX2hoKI/HgwPXGRkZHR0dcMUXbWl5W2PB25GWlmZlZQXLvgsWX3ihOAIWHRhiv45GUq1l7+8K12wJ29dAUq/CbCn2U8p0k4m3kwq3VSa5axEPbDq2deMO+XVyaru3okMCe/t6kVd59vQ7t91UKwkabn1F5Ob+ZI3T0fJTc40rtfzr7OooKM299tHc2TOnM7KLVP2DFMlhO+mxQUdb9vpy5OmUmvaO0aEhqHI0OTpihQ4BeoYbffy16WzntGzbrILdrJjwyEguh5MUGxvP4bAjI33JFBnjE2tsHTcGhmwihq0KxnfNzS9+6Y8nJuolJacBuC4vf9/b+9f/wDSwq6srJiYGACAvL79+/Xomk8lisaDsc2hoaFpaGlSUE5UTFtW1RtD7Jhazs6+vDxoCwqX/1q1byICiaFhZyS4Qi8Wmp6d3d3d3dnbGx8fX1tbCoSGkgW9BDujdyPf06VMUCvWWxRdHwAb5hViuxfpu4BF2VqI35/mu57nIcGyl6bYb8M5aoSftsUw6G4MPBqvBRlUVzQ80WSxWc3PzAmHhuakb+mIn3eXjyBvqOWqCpJ1nkrbNfn3vbW6/v+N1Wlp6QXx1MaEvUatLX4Mh5u+9jcbaGx/t6dYQu31i9Umse0bq9MgIJN+IQMBLTt5sZgFMLbYHYvTZHM/sAuPMAl1mJIZGswrG7PfwVrJxkDK1kDY0lrW02eAbsAlHkQghYKoWWqE+f/asUlV1DICP9u9/aGJyRUrqX0ND7/TxIvj555+zs7P5fL6Pj8/GjRu1tbX9/f2ZTCaTyWQwGKGhoYmJia2trb29vR2/o/NNdL2JtxO0ubm5ubn5008/ha+enZ3t6+u7IKwszqktpiAWi83MzIQiiywWq6ysbHR0VCAQwHG1xamfdyOfUCicmZkRXXyRzMtvfab4ULR/iKVSqL0c3VuR67k23kGO4XIA6++KwWHxVAaJwaaRqWRDQ0MxMTEAgKqqal1d3ZJefqVxLUeBn79SJl2lLWH3ROyG2XK7y28RvH/2zQ9z/HsVuFHC1gqyQhNBqpmp0INWL1/j4q4QjFWjs9QTo0nGA367G/cxKSOCIeiGODw8nJ2ZGR0Xt9bMQsrKfjeWdCI+RYfCkLK2lzAxB4bGYseMVhsYSRmaSBsaS5taKLp5q4YS12DJxikLndz6MZg2AK5v2fLAyOiTQ4dmALhDp7/rxwtx//59Lpd7+vTpR48e0el0eXl5JSUlMzOz6OhoFouFw+Gio6Obmpr6+vra29vbRND+JjrexHIEhXL4iGDrgwcP4LQoklNbSQgkEolYLDY7Oxv6dpDJ5OzsbKjpCMclF2d83pl8wrcuvqFYTHBQiPV6rL0c3VsxKVS5jKRcTw5iUVh4MoUEuw02b94sLy+vrKx88ODB3t7e5V7l1atXIYYcE4DDrC9mqfbCzMsob6GZ5VcPnkzV3CryHQnf0Ry6uha3ujFcpZu5vYu1u5O9vzNif/s2Y29JD3elUOJONvuD6ET2rsko96bhWT4k38jICI/HKyss5BUWAT1DRXef7ScDJfQNJY8ZSRmaSB83kTYylTYykzYykzYylTY+IW/vrOyPBp4oa27qS5FofXd4qBqAi3Jyn+jqPjAwuKKsPAjAzbCw9/h4hULh6OhoVlbW1atXr169Cp3SZWVld+/enZiYGBkZicfjw8PDa2tre3p6WlpaELVkiM62tu6O9rbWP9D2JhYTFApFzs//sZEoLS319vb29/d/O/9EKQgNofPy8vr6+lpaWkJDQ7lcLp/Ph8FvyUTP+5DvyZMnyOIL+fdH2hmLQQeGWCmHIuQjKzYR3COJNCxsNKdSqXDQZtWqVYjv6nL4x53PTqwNdpSJIK6vid42yN19OlZ55h/nv30t/PXBta8GsuczbPspKg2YVbV4qaawDR0stS7Wnk7W/g7mB61h+xpIu6qIGyt2a/gACxN5H/8NeOrOGLYhISdzx8WO4iHBVP9A/8DIyEhmZmZySvLt69dC4xLAseMyphZShia/E+432kkZmkjoG4rr6EnqG8qesNzuG7AvItYwLad0avbHX355/d3zkp07x1et+lRd/aGx8Ye7dk2LifVKSn5zfQmZjpWgoqKitrb2448/7uvro1Kphw4dUlNTs7e3DwwMjIqKgjc7MzOzqqoKkWr8beqqvb28pia7orKlubmnva1ZBC1vQoScrZB80JIE4ssvvwwODkYaSpDg8pbMLuRiYWEhn89vbm4ODg6OjIzs7OyE/lZLZh/fh3zC3xdfLy+vBYsvJjQEHRBspRxqJ0f3UkwMVS4lKzYS3KMIVCyNRnNwcNi2bZuysvLevXurq6tX8kJ9NRO6wNd3XQptQ0v8rvGE7TOx+/uSTXqIa+sxq2qJss2MTR2snV0sjU6WZnu4ZgtNo56wszJ4U4GXfIrtKraNOM1uP2GNiYmkpa28H1qVRN+ZEOHsVJu3/xy/t39odGB0ZDQrKyshMfHy3Nz05OQm0xOrDIykjUyljUxljEzF9QzAIR2xI7pSegYqljZ7vE9uD8Rsx5GPxyXbp+caJPK2hkcbZ+U7syLXu3gaEaiNPqgvNDUvSkv3AXArL+/9Ptvnz5+npqYODg7eu3evrKwsLCwsMTERh8MpKCgoKSlZW1tD33ko4gunXuDUc3tzMzYuYR0qQDYg5IMwZkJRcU9ra1tzMxwIFOWoKOCa29TUJBAIRJsm6+rqXF1dF8eX5XaB8HFRURE8wUC73sbGRug6JJp6hOnG9yefUChMS0uztbWFDVdI5iUEExzkj7ZcQD63SDIdHxERoaKiIi0tLSkpCbNKK0S0b+4xgEYr5zM3dbM395DXNpIVWsO3dLLUu1j7OpkftDE0myh7avFq5UEque4yidZi4VYyZPfdtDD3pHxemYA/GJWaBnT0pe2dFYJCt9LC9yZE47T7y2xmh6f4Y2OjhYWF8fHxZ8+ePTszfcDeARwzkjY0kdY3WK2rv8XazoNIOo4nnYhN8swp1E9KVyTRFQJCNmJJe+hsg9gkx8x8TTIDOHsoMiI/SM7Yn12UbmR4BoApK+v3KQsKhUKh8ObNmzwe79y5c7dv305KSqLT6XFxcc7OznDx1dTUhP2ePB4PTl3BqeemhobU7BwJIzNxG0dZD19x3wCpwFDrmPiyqqru5uaG+npIUFEg4sSVlZUFBQV8Pl/0Mp49exYTEwN72hdXthaHQBwOFxISkpiY2NjY2NnZSaFQsFhsRUUFzGNDTwTE/hRKor0/+b788ktnZ2cPDw/RzV9wCDrQL8hSGSNKPooXh0zH29vbb9y4UVxcfOfOnY8fP175C3375JnLTorVahpBpYq1vYu1uwsurL8lDreW+CtneaxJtJdkWcuTUIeYMZiMrJSClrbm0clhwdjQwGD/zPi4J4UGdPTWuHqtCyFsYzGPsFOit8zWUkcnLwjy8/NTUlLOnTs32Nen4+QCDI1lLKxl7RyBvUtITv7s+PjJ/BL3/JJDnCQJNFbBzQvo6gNLWwVUoAqWpE4MU/JCyeMpmtEJpskZm5ISDruSB6TXf/vpO09yIOjq6srNzb1w4cL4+DgUDGWz2QwGQ0tLS01NzcrKytPTk0KhQPJVVVXB2b/mhgZiVDQ4fFT6uKmMpc0aZw9Zbz+ACtyIJWNTMxpra1vq66tr/kDt76ivry8uLs7IyFgcEb7//vvk5GRbW1t4vvzTEAiX2urq6t7e3qioqMDAwNzcXFhT6evrQ/KLvb29UH/y/cn36tUrPB5vY2Pj7e39R88BOigwMNBeFeMoF+almIBTLg1XaqR4cY7oHxQTE1NSUuJyue/he3th/JqRZBBKKY2p2Rq2r5G0qwqzuch3XZqzZIy9DNNFle6iifcyD+ElpQ+NDAgmhppaG3t6//CEGBwYGBkaPOzpDY4dl/M6qYwlb49h2gaVpqlc7K4YSc3lFhYUXr58ub66WtfJBRgYy1jarnH3EfP280hISq+utcvIOxAdD3wCbOIS7336qLStXcvTG+gZSNs4yDq6ygZh1VgxRtz0g4lJ62mRAbtbJrbqPjQ3/ufvLc3viqKiotLS0gsXLkB1VMg/FouVmJjo4eEhKSkJrZQyMzNPnToFhaPLy8ub6ur8w+jg0BHpY8elDYylTU7I2jjIuXtL+QaI+QUfCmMm5ee31tTUVlVByiKoqamBJmdLLkevXr0qKiqytbX19PSESzAMgaL8Q0Ig9G2rqKjo7e3l8Xj+/v4JCQnQ4xlxKW9raysqKoqJicFise9PPqFQeOPGDScnJxcXFyQyBwUFBqLRWir4EzJ0L8WEYOXSEzLN7PBqZxcb2KMragD0TuAEZ+sDtO+6VG/5FHvxCFvZMI+d4cEn2DifsEC/IFdPp0gOq72zTSAQwB3MGzaqfX2jAkFza+uGE5arTC3kUYEqRNrOeDbmRE+e5rmY6NiGlrq5ucv52dlHnV1/I5+rl4S3n2l4RGBu0d6IWODt55OS9sct+fln3qnqtVa2Ut5+62ks3fgUQ27a+mimjV5D2ZakzxwsH+rr35KT+zwh4T3eaXZ2dlVV1dzcXGlpKTylQS8/Doejq6sLAJCWlj527FhRUdGpU6fKysrgtGxdVZUPiQIO60odPSatZyBtYCRtaCJzwnKNg6ucF0rcN0AWQ7CLSywuLauurIDjghCnTp3Ky8tbjnwQTU1NdnZ2bm5uyI1eMgTCXtSioqKenp78/HxfX186nV5WVgbtemtqaqAyGlygcTjcf0Q+oVA4MzPj4ODg4OAAKYhGB/n7+8nIE8RBpOLq1DXiNQAMbN/hvmOHirq6OofDWYkV9AJ8+eWXAwP9/IG+xNACtx101IEImmcih8Fls9kheLSbp7O1jZWnp2d+fgF00KupqVnSRnVqfDyzqEhCz0DK2l4hIGQjLUw7Mil211muQVffSOelSxdTudyjLq7A0FjG0maNq6eMb8BuUphmZJxUQIgLK/LszMyVT+7VTc8ST9UYc1P3R8WtJ9M3kBm6sVzz1KwtiZHHnEo5cmWDGzbN7d31oZHxPWPjqzt2vHz27J3e7C+//MLj8RoaGs6dO8flckkkEo1Gg4W18PBwHA63a9eu7du329nZQVOd0tJSOLBdVV7uGooFR4/JmJyQPnZcSldfSs9AysBI2shUxtJ2DSpQjRGpEcvV5ySUFBeXlf6BsrIyOGkLvV6Xw9DQkIODg5OTk6+v73LNnWg0mkAg5ObmdnZ2VldXx8TEVFRU9Pf3t7a2pqSkwHUZg8EgZ5T/lHxCofDy5ct5eXlQ7JxCITOZ4SoqdADYQCwNgFoA+gE4uno1cHZ2ftd/+aeffjp79mxTU9P4+PhHH92+c+92c0tzMi+ZGUU/GeDr5Ozo6Ojo7Oxsb28PheWGh4ebmprq6+sXuEEglaXZiQl8DAccOSrr5L4OjVOJoDmjK9IV55tjp+c+PMuNizvq5AyOHZcxt1zj7C7nG7A2GCeHIazzCzKJ5OyihsugcasCMJJBOCU8VY3K3B8eqcWMtOLx9HK52gGZeNkmClDOBaBJUmpYSWlKQWFs48aXy8+BL4kff/wxOTm5ra1tenqaxWKRSCSqCGD8s7GxWb169XoVFSKLVVpfn52Tk5uTU15SbB0YBI4ayJhZyFjayFjbyxgag8O6EkePSRubrfUN0GHHoPKK93CSQpNTq0qKocYK4qeck5Mz9Gf1mHPnznl5eVlYWHh5eaFQqMUlfjQaHRoamp6e3tra2tLSkp+fX1dXB2mHRqMRziH4L5BvwWf3yy8/a2omA0BftSpNTKwWAL6MjNHGjSqIp+gKce/ePSiRBiXlzpw5U1JSEhIS7OLiAp0RoVqyk5OTt7d3Tk4OrFTW1NS0tLQsVtWF/Ovv758cHbVAhwDdY3LuPutCCWoRrIjjowVbbvQWjMZzwvVc3YGZpayLp5wfWj4YrxBKUsJTNpAZSqSwzVSGOoO1n80+EMHSimRqRYRrMRkHqXQdfLSLSzlpTVdf0pkBHidy23YSALEApAIwl5n5rh/g06dPExISYBswlUpdMMVIoVDYbPb+fftgzddfU7OGwUjPzU3Lzy/OzzP2QQE9AxlTcxkLa3EndyMi5SQOv0bvGNDVV3Dx2E+mO6Vmm6Xl6EXFluT9gfz8fCiCCz0Q345vvvmmvr7ezs7O2dl5cQiEfqpcLrepqam9vR2Px/v7+6PRaNGk4F9IPoh9+5J+J18NAO2amv5Pn3658j9//vz52NhYc3Pz7Ozshx9+eOXKla6ursjISET0U9Si08nJiUajNTU1DQ8Pt7S01NTULGnIhPBveGiov69X081J/MQx+ZMeCiSsQUha+KFRa4csNUrIWjxuDYm4Loy6nhGmygzbzmbsjgjXjGQdiojQZUUZhHFM8PGWAcn2bmluFtk+Rwv8NQrRG0oCQVmu6295ih+++26mrq4lOvqqyATayvHFF1/ExsYODAzw+fwFgzzITJanr6+GqioZgC4ABgBo19TMY7NzCwsPu7kD/eMypuYyFjZiDq42NEZNSXFsfIKmveMqU4utQaEmsUmeuUW7o+JZKbyCnGw45p2dnZ2enp6Tk7MS8gmFwo8++ig+Ph6Lxdrb2/v4+IiGQBgFORxObW3t4OBgdnZ2YGCg6JTtAv79FeT7VYR8tQC0GBszhMIlqrdL4t69e42NjQMDA9evX7958+bk5GR+fj4ajYbOnKIi3dCxE4VCpaen9/T0DAwM1NTUNDY2Lqcq3tfXOz7eOzHZMzU+HJ9cIbE3VMqYLUfCbcIyPA2qHY0q1HDRB7GJhljeCUyGXUiOe1Ah6mRpoEdlqEMN4UQ9Wa+BeqCBsrOOuOEUWjrfB/BcQayDRLjbRhb35KnnT99z3GQB7t69y2QyoYkFkUhc3MWExeEwJFLYBx/EAZAJwCkABgAYlpQsPHlS08UNGBjJmJrLWNqIObrZUsJy0tJys7I4cXGyxmZr3X0O0dkeWfm63AzrKE5BRjoUu0hPT4ez4hd+NxB9C16/fl1eXt7S0nLjxo3ExEQ7OzuonI4kYqA0cmZmZmdnZ09PD4lEgt3/S/LvLyGfhsZv5AOgBoDG4eEvVviXV65cqampOX369CeffDI3N9fS0sJisaA/CeJtJMo/d3d3FotVWVnZ0tJSXV196tSp5dxw+vp6enu72exOG5vBbduHZaRmAZgH4JrSnv7oPYIMpXO89WeSDo0nG46n6I8l644maQviNQdidvewtrfRNtbhlcrRCnm+a3hOMpHOGxhBhzkUx8QEStbczPXnz/47tIO4c+cODoerq6sbHByEDSwLSqgYDCYEj8epqOABoALAAyBeUemgjcMmnwAFM0up4yYypuYylrarnNydKbR0LjchISEjJUXb1U3MwmYXlmSVlOqUXajB5sQlJvKSk1NSUrhcLplMZjKZSFfLW/Ds2bOkpKS+vr47d+7U1dUFBwdDJXQYAqGEemBgYERExKlTpwQCQVZWVkBAgGhFWJSCfwn51NXjfydfLQDNU1ML9ScX4/Xr1zMzM/X19XNzc/fu3btw4UJOTk5QUBAsb4sKwyP88/DwwGAwUPK8pqamoKCgrq5usRVJR0dHV1dnX1+7vn4RAAMbN95av/4jAObhf6vAtYC1p5M3j8aoCKJ39rM/6KCrN5G2VmM3FKMVslCyXFe5GDsFqrkS2nCjm94Oq5POwQW5RVeuz9++e3NA0Dd7duanF//+03e3cjx//pxCoRQWFgoEAg6HExwcLHrDCAQCGo3GUig4E5NgAAgAEMUlNhkYAQ8faR9/KVNzaSNTGVNzWStbcWcPZzKVGxsbExPDTUjwxxPEjptuQAXqRXC8c4o041K8IqJSExISEhJiYmJIJFJKSsqPP/74p5f34MGDhISE0dHRGzdupKamMhgMOp3u6+vr7Ozs5eUFd4EnT57E4/GZmZmwZQaPx4v2RYtS8C/Z86FQpwAIAYAHQOmaNY2PH//Jie/FixeDg4PNzc3Xr1+/d+/e9PR0QkICLJwsaW+EQqFgOExMTKytrW1qaioqKqqoqIBVI1H+weA3ONiTmFgMQKKS0oi5+Uc2Np/KyV0B4CwAswBMGcsNxGxqo65vDFUs9lPgea7hOMiHmW7AHd6D+UAbpadhonNQT/uI9iGdA5oHNZzdHdMz0kZHR6CTXWtra09PzzsVbP4UUINHIBBkZGSIhg2oEubv748nEGjh4TRLS5y4uPtqSQlYiba0lT5uImNsJmNqLmtlJ+Hi6Uwix0ZEsNnsyIiISDZb1cJa2sFlH4nulJplkZF3KDwyLiqKExMDi3Xl5eUruba5uTkulzs7Ozs3N8fhcKCSH5vNDgkJgT6jMDQEBgZGRkZWVVXBd+Hn54cUQkT595eQ75///NbVtXjDhogDBzIFgo/f/svffvstNNu4ffv23bt3h4aGWCzWcvZGCP+8vLyoVGpZWVlzc3NlZWVhYeECT05RV4WhoW4WqwAAhopKg5bW7O7dl6WkZgDoA6AdgFOGgOsoxTBXIhzddHKvmtNmLbt1hjZrnFwl0UHrT3rr6WnrHj2io/ub28LRo0dJJFJ1dfXVq1fn5+f7+/u7u7vb2tru3n2fKbslUVNTExYW1traWl5eDmVhYRUBCnX6+fnhcbgwOp2TnEzy8fHevl3q0BGJY0bSBkbSx47LmJjLmFrIWNtLunp64glsOh3mCKPZLDMvb2BivjUo1IST6JVbvCc6IYjOiGazaTQakUhcUNhdDkNDQ+np6RcvXpyenoZhj8FgwAIgmUz29PR0cXHx9vb29fUlEAgw+HV3dxMIBPgtEqXgX0U+iGfPnv/665/MMXz//fd1dXXd3d03b968c+dOe3s7iUTy8/MTdR8Q5R+kIOyzzcjIaGxsrK+vLygoKC8vX1LYGfKvs7O9qal582YmAJFiYmUA1AOQC0C8klK40ZGwZEqGo08o0NgHdLRXGR5dfcJU0spK1sVd1g+t4oXSP3pUT0RwXEtLy8nJicfjCQSCjz76CLqawD4OaBX2n2N2dtbHxwdaacbGxqJQKJjIDQ4Oht9JmFFDo9EYAgEfGmpqayd19JiYjj4kn5Sx2WpzKwl3H3scIYz422GFSqEEh4Yixw73rHx9XpYBlc6mUqGqxAovvqGhASr+9vX1kUgkpPoCp3cZDEZAQICzs7O7uzvs/qqqqhoeHoaL72L+/VXkW6Bo9vLly5cvXy7oQ/7111/b29tbW1uhUHBlZSWU20bsBpbkHyQflAFtbm4uLS0tKChY7AaG8A92r/X1dVZU1B8/HqumFmFszCWRsoqLa6KiWIVFmVOzY1evzUem8jYcMxTX1pE2MZcxt17j7L7GP3i9jx+iOI54ROnp6ZHJZKigNT8/D/uFoEPn9PT0e5RwFuCrr75yd3cnEAjFxcVNTU3w2wh9xZCvJaxuBQUFoYOD8dhQLxRqu7HZKj0DmRNW6xycNbFE/UTeAWo4Fh2EdKCQcDgNa1txKzt47HDJLdrNjArB4Yh4fGRk5NOnT1dybQUFBbW1tTdv3qytrcXj8WEigCxkMpk4HM7V1dXNzY1EImVmZra1tc3MzPT09MC0n2gvwjuTLycnB6nPVldXh4eHC4XC1tZWCoUCn/z666+9vb33799Po9HgnfDy8tLU1Dxw4ICVlRXSVZCSkkKn07u6uqA4f1FRUUBAANyZwlVmOf6hUCgikVhUVNTc3FxdXZ2Xl7dA23RJV5mWltaens6Bga7u7naBoGdycrC7u53JDK+oqBgfH7948eLc7KxjRLSEvqGUgfFqc2sZZ/fVvoE7rO2O6RyB2vPa2tra2tqHDx8+ePCgs7NzamrqyMjInTt3oGfi0NDQwMBAW1vbwMDACm/kW1BVVQULaNBRgslkQkujoKAgDAaDfBoIMMHBuODgA9a24ubW2zF4y6Q0n4JS9cg4tyA0JigIhkkcBmPn6SVuZLYBFajH5njnFB1ITLXA4v08PCoqKlZyVf/+97+5XG5jY+OZM2dSU1PhNCftTcAyIJVKhSdCUf719vZCt1+kF+Gdyefp6QmH8hsbGzdt2nTp0qXq6moxMTFDQ0P4C97e3q6uruPj45aWluHh4d99952mpiY0nvvkk09g8Pvuu+8UFBQOHz48Pz9/8+bN4uJiZGcNvxZL8i8oKAgmM2Eas7m5ubCwEPrRL+bfcn6qnZ0dnZ2d0EmbzWY3NzefPn363Nmz3R0d6tTwLXaOHxzRWWtwfLWegcpR/cPa2jpHjhw9etTIyMjKysrExERHR2fv3r0aGhowITI3Nzc9PQ1lr+H0NazsPXr06F0/WFG8evUqJiYGZnFhpPf19YVuKBgMRnQTgiA4KMjL11fG2Gydp682I8IjK/9oSqZuKCFUJP2LDgxUMTWXcXDdRwpzTM2yysrXINP9fX0ePny4kqv6f//v/7FYrPr6+tnZWR6Ph8PhkLoL9U3Q6XQKheLj4+Pp6Ym4cU9PT/f29hIIBGiugcFg3pl8AQEBubm5o6Oj0RBRhwAAE31JREFUampq165dEwqFY2NjmZmZlpaWQqHw66+/3r17N9TffPjwoYGBwfnz51VVVdFoNJFIPHv2LPxHamtrt23bpqmpyefz29vb4VIreqZbjn8BAQHQFxNq+0FLQcQQcUk/1SX9fPl8PrSb6+zsPHv27LnZ2dyKCsnA0L1uHgEe7lQyOS4uLj87u662ls/nz8zM3Lx589GjR19++eUnn3wyNTVVXV1No9Gys7ORiX84IwhDYE9PDxSS+m6Z2d4V3umgoCCkl8nf3x/x2UL9jpMi8DvpF+zvv9PcSsLGQZ1ItE9Pds4vUA9jnzx5EuFpKDpIz8FRzMxyS1CoMSfRK7d4Sxg7Pr9ghZf073//OyYmpqqq6vTp07m5uRgMZsHorqiAAexboVAogYGBSMF3enp6YGAA2gr5+fm9M/moVKq2tvaqVav6+vqQJ8+fP29kZCQUCk+fPm1qagqffPHihbm5eWNjo4mJSWFhYXp6+u7du2H1+vDhw2lpaQQCwdHRMTw8HEmCv51/AQEBFAqFy+VCY7e4uLgFnsQL/HwXH35h8gWOcjEYjLS0tO7u7rGxsUnBMDaZB9x9UCkp169cgQK3b0dpaWliYiLkHOJqB5VToFJJS0tLb28vFOB5P9y9ezc8PNzPz8/Dw8PR0dHV1dXBwcHS0tLKysra2trOzs7JycnV1dXDwwMmngJPnjR1dBI3N1nvHqrpl+WcXKLFSzwREBSE+q0CEejv7+HtLWtkutbd5yCd7Z6Z90F0QlzvSrvKf/3118TExLKystOnT5eWloaEhCwYIBflYlBQEA6HI5PJ4eHheDwezhpDudzz5893dHTExcW9M/koFIqamhqbzTYxMUEEhycmJoyNjYVC4fnz5xG9sJ9++unIkSOiIb2ystLPz29+fh4AYGZmpqOjs3nzZqhnj10EUf7BtYZAIEAbS6gEn5GRscDPckljhaUOv51VVVUUCqWkpARq7Qz0dBmxycDFrWr0z0tMENCjDM4iiJIP4R/07urs7FzhorYcnj59evv27cnJyVu3bt25c2d6erq7u7ukpASaI4eEhPj4+EAvAxtraxu7E+s+8AYSrYprr2zdfk0jpPoQA3vS0xNWJn19fQNPnlS3sJSwstsZSrRMTHXMzDvGy/zhxc8rvBgej1dYWDg7O1tdXR0cHEwQwRs1QCw2KCgIjrRBASt4Q1NTU1taWqCizcWLF99n2Y2PjxcKhVCuGT6JkO/Zs2f79++HdgA3b97U1dWtrq6enZ2Fv1ZbW+vp6YnBYDQ1NYODgz09Pbdu3ers7Awvdzn+wS7F0NDQ2NjY1NRUHo/H4XCSk5MRbdN34h9srM3MzGQwGHV1dQKBYHRkuL6ucaNBMlAuqqp8uMLPoaOjIyIiAoqUwRHMBYDLcXd3N/R5f9fPeYX46aefvvnmm7t37166dGlgcCAvL196NUdSYujYsVvmJl8oKl/fFJxi421nY2kBY6ePp+cJB0dxY7MNvgHHImNdM/M2ksPbLs6t8OWysrLS0tKGhoaqqqqg7Z4oEBbCDj8oNclms+l0OmxGDA0NjYmJKSwsbG1tHRkZeWfyubu7wxPuDz/8oKGhkZ2dLRQKBQIBIhNGp9MNDQ0LCws1NTV5PN7Q0NDWrVvz8vJ4PB6cPN20aVNeXt4nn3zS2dmpo6OjoaEB542XA1x2IyMjoeo5dFVdbOm22NJS1FJVlH+dnZ3R0dFxcXFtbW2jo6NjYwNJSdUAtALQU1m50tmLoaGh8PDwgYGB8fFxPp+/WJ4M4V9vb29bW9uVK1eWFNT/7+LRo6cAMNaurTt06LTWwSs7Nn8E1k5R86t6O1twOJy7u7uzs7OHm9s6g+OyTm7bg7FKfmgp38AtBGpyd9/jJ39+SM/Pz6fT6W1tbfX19Ys7BmDFFovF+vv7Qy4yGAw4awezibA8iMFg2Gx2Xl7eO5OvtbVVIBDAx5cvX05LSxMKhR9//HFhYSF88vnz55GRkZ6enlwuF0q91tXVwd6HwcHB8vJyKysrKNgbExPj5eVlaGiIw+GWpB0Oh4P9sVBHLD09PSEhISoqClEAhk+KCtsvaSwjmnxpampqaGiAx4Xe3t7R0dGxsR4UqhyARgDaV06+qampsLCwvr4+qD+MTAQu4B9cgvv6+tra2s6cOfPiTfWWxQIMy0kyIOnDFy9efPvtt8+ePXv27Nl33323gNA//fTz/v1JAEQoKNQqKgp27ZpTVLhx3OIjoVD46tUvX3/99f379z+6fZtXXil21EDKzFLaxkHOzVvSEwVcvDbhyLFtnV++lYKdnZ0nT56srKzs6+tjMBgw9SOaOsbhcDAjATsRWSwWNNH4TcoHh4P7P5gq/wsrHEsiJSWlqKhoaGiou7sbXsdbwh48bRCJRCqVGhUVBQ0RV2KssIB/oofflpaW4uJiKpVaUVEBh5n5/LbDh4sAaH4n8s3NzVGpVOje3tfXB+dS38I/Pp/f3d196dIlUf5VVVVRqVTkR29v76mpKaFQGBQUhMw1Dw8Pa2tr7927t6CgQCgUBgYGbtmyRV1dXUNDY8uWLVDy4aeffnJ3d79//75QKJyffyAjQwQgZs2ahg0bxvfsmZeSvEqjPRS9+IdffCGtb7j62HFpI1MZM0tZW0c5Ny9JD1/g4qWKI4fXN93/aulz0j//+U9/f38ej9fb25uXl+fr64v4DkOxnsDAQGjNjNxEpDyDAHIxODj4byXf69evoZHQ4OBge3s75NaCkvOC1RZKOkPtNyKRCMuIy7lqiTqALZd8aWlpSUlJYTAY9fX1IyMjo6PDlZW1iop5YmItALRXVNxf4Xu5ffs2lUptb2+fmpri8/kDAwOionfLLcGTk5OiBlefffbZnj17oHVHfHy8jo7O06dPofVXVlaWUCh88OCBqqpqVVXVmTNn1NXVx8fHHz58CC3U+vv7lZSU7ty5IxQKx8bGAACQnUKhsLPzEgD4VatS5OVbN26cUle/CsB8UdEf3Q/zH34orqMnefS3OSPp46YyZhayNg5yrp6SHr7AxVMRjQ2rabjzxRItwBkZGWg0Oisrq7a2NiEhAekkhWYtvr6+cFADjUajUKg/KjFvArLwbyXfq1evoqKiuFxua2trVVUVUjVfzD/4vCjzsFgs/FHU0hLh3wJjj7dY+jY1NcE/b2pqGhwcHB3lR0aWiInliIu3ANDR1fXZCt/LP/7xDyqV2tTUBCMf5B8ymr9kCBwcHJyYmLh8+bLoWnnt2rW9e/empqbu2LHjs88+e/369dDQEIFAgCaURUVFyOxLWloaCoVC/jApKQn50c/Pz8TExN7eHvm/QaFlAGAlJLLWru3avPn0jh3XJCXnx0Z/Ky/xp2fAwcPSx02k9Q2l9Qwk9Qwk4aiRqYWspe0aZ3cp3wDgF7yOEs7lDy5Y2a9everg4IDD4VJSUmpqauLi4mAKFjZZwoU4JCQEaS+FTfYIgkTwd0c+MpmMx+OLi4vb29sjIyNRKBSiQwjzzPBLg8FgoIEblBzEYrEwh4QYe6zEWGaxq2VNTU11dTWcuG5vbx8YGBAIuj08sgDIkZBoBaBjcHClfa/3798nkUinTp2CErDIUPRb+AfzMrOzswvqb21tbQAA0b4S6PUtFAqhIxd88vTp0ydOnICPnz9/vmPHDmhh8Nlnnx04cODZs2fm5ubnzp2DvzB35zpY6wJAhKRk/rp1fdu2ndu8+Zqy8tWP730vFArr+P3gwCEZMwuZE5bSFtbyJifEtHXAIR2ZY4YyljZygRhFGmtbROye6AQZQljP/BsmUK9evWKxWDY2NhgMBh5vYdEM1mBgKAkICICVaAikDBMggsDAwP/Bns/Ozi46OrqwsLCkpITBYMATOFSagTEZ/kij0SgUCnwzojmk5fgHXQXfnnyBA9JEIrGgoAB23vf1tR88yAUgT0KiDYCO3t6VSlBev36dSCRWV1d3dHS0tbX19PSsJP4JBIKpqamPP36jzezx48c7duwQFQRnMpkwnxUTExP2u9TVwMAAQr6MjAxEzL64uHj16tX+/v7KyspRUVG//xu/6qGDgaQPANHS0qWKSoM7Nl9R2n7maFz+y19/rWzvAB8ckjE1lzlhKWZp68TlXbv14YlgjLiNowKRpsKKUY9OOBDL3RudsApDpDe1LnjvX3/9NZPJhBa9Pj4+sI1ZtOIH04qLKzEL6Ph3k+/x48ewRh4aGspkMrlcLovFgsyDmzzkuI7sYRekMRH+iboKLuDfcsmX2tpaHo9HoVAqKyv5fP7Q0EB5ebWEBAuAAgBaAGi6cePJCt/ImTNniERiXV1dZ2cnJB+cUYJz+cvxDyolXrhwQVSS8MGDB2pqaqLlYIR8ra2tSNEci8XC08mLFy/27NkzPj4Onzc0NAwLC8vOzo6Li9PX10cONIXtzeCA3qo1JADiZcTrlVWGNbHZygwqsbUzIjsHaB2WMbWQMbcCJ6yw+UWTN27tZ0XLkcO3Rcbt5yRpcpLU2Bx5Eh04efAvLGGB/vLlS+jA7eDgAHuo3Nzc3Nzc4GChl5eXl5cXvNGQnTDFvYCOfzf5hELh5OQk/NKgUCjR3QAWi0VYCDeq8HC+pBQhHGJd4GoJ+Sea/FuQfKmpqYmKimKz2VACm8/vaWho1dLiARAmLZ2QmXl+5e9CIBCQyWQoioOQDxHoWLwEi8a/yclJ0bLb/fv3161bJ1oIIRAIsHvj+++/NzY2RqFQTCZTVVUVhszc3NwjR44gl7Fjxw7kD48cOdLc/JtY+eOvv1G0tVxt4CImTZBQCVdyJW4LI2lFxG2LiF3nFyQJO09PWMo4uGzB4KVCCApU1p6YxAOx3D1R8ZvCo8QCQ8WcPWIqq14vL8g5Pj6emJjI4XASExOTkpJgM4Gjo6OlpaWFhYWVlZW9vT2kpqen5wI6+vj4/A/IJxQKKyoq7O3tPTw8YMcAMvIJz+pw2PMtDh9v4d/bky8VFRU0Gi0pKQn2PjU1NV2+fOnly1/m5z95+PDdWuG7u7vDwsKam5s7Ojra29sRdQ6ItyzBAoHgzJkz10Wk+3788ceCggJRp9PR0VEksH3zzTdsNjswMHBu7rc6RGtr68zMDHx8+vRpxIhBKBTCBCryox8nDhw6JG1gLG1mtMbJfn0ARo3C0IqM2xoZJ+vuI21gJGvnJI/GKVDCt7A5mpwkTU7SdjZHgcwArt4HcaSpuXdrj339+vXTp0/v3r07PT3d3NwMy0iwvdTa2trc3NzS0tLW1tbJycnNzc3T0/N/Qz6hUDg3N+fq6urq6gpb9OBXAe4GVuIwA/lHo9EWJF8Q/olamkP+wbZTAoGQlZUFHVTq6+vfu/29vr6eyWS2tLRA8i1WPF5yCR4eHh4fH79w4QLCnr8UExcuAvW9EvrHpA2OS5uckHdyU0Fjd9FYB2MSNjOjZVGBawk0FWbM7ugEGPA2hkeBAIy4iwezuHQl80QrwQ8//PDpp59euHChq6srPz8/KioqJCTE3d3dxsbmf0Y+oVB48+ZNe3t7BwcHuG9d0mHm7faCUGf3T5N/MPlSWloKW2ny8/PhVGljY+N7G1uWlJRERUUhKrMLdLcX8A/JAg4ODp45cwZ2Cfx3P8zlwMrOBfsPAC1taQMjaTMLBVfPjRjCHnqEVkziRjZnM4vzQSx3f0zidrjDc/HSo4SdfheP4/fAixcvvvrqq/n5+f8l+YRC4cWLF2FrENyTIsmhP7UXFOUfYiwYFRUFD79LJv9KS0vj4+MpFEpZWVl3dzec5335vm4Z2dnZ8fHxkHnQGhiR2F7AP9Et4ODg4KVLl4aHh588WenJ5j/H2Nlz2u6eYLfGqqP6MubWaz19VbFkDWbU5jC2EjVcjRWziREpFoCRdPOKO1X98j+wb3hX/I/JJxQKL1y4YGVl5ezsDKee3iJCiF3GDYdMJv9p8iUnJ6e8vBya01VXV0MpbaRI/R5ISUlJTk6Gay5CviX5B7eA0H1FIBBcvHhxYmLib2gyEMWLn3/mlpbJ6eoBzYMylrZKPv6KgRi5YJwCnqpAokuiceasyGt/WevNcvjfk08oFMKeexcXFyT+LacAtxz//jT5l5ubW1tbC6ciGhsbe3t7GxoaEJ+0d8Uvv/wSExOTnp4Oj7pIg+pi/i2UaZuamp6ehh3gfz9uf3LPHk8EWtqrTU7I2jrKeZ+UDwpVwJFXYwhu+cVP/0ubvJXj/wT5hELh2NiYubk5FF5YIf/+NPkHky+pqalpaWk8Hi8nJ4dAIKSmpkL7lLq6uvc+bfzwww9MJjMnJ6ezs1NUl2MB/xaEwK6urosXLwoEAtF88t+PkpZWsUNHgI6+rJXdGjdvef/gtaEkEITdyogYuPK3fiv+r5BPKBT29fWZm5u7ubkh66+o/NtK4t9yyZekpKS4uDiou5OXlweV1xoaGuCsyXvg6dOndDo9Pz+/o6MDId8C/i0OgXw+/9y5c6Ojowvslv5+jJ8/v8PGHmhpy5hbrXF0k0MFrA3Brw7GrwrGR7R1/m2X93+IfEKhcGhoyNbWFg4l/Lf4B6c9OBxORkYGlUotLy+H5mAdHR0v3ndz/fnnn5PJ5JKSEkg+xAZoMQVFQ+D09HRHRweSrvvf4vl33/lHRq86clTa+ISsjb2cp69CAEYOQwD+IboJKbc+W2mZ8T/B/wckE+pGpy2UYQAAAABJRU5ErkJggg==) 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Związki fosforoorganiczne są wykorzystywane w leczeniu wielu schorzeń takich jak choroby kości (osteoporoza, choroba Pageta, metastaza do kości), infekcje wirusowe (ospa, zapalenie wątroby) i bakteryjne. W naszym zespole zajmujemy się projektowaniem i syntezą nowych fosfonokarboksylowych analogów bisfosfonianów, inhibitorów Rab geranylgeranylo transferazy (RGGT, Rab GGTaza), enzymu odpowiedzialnego za post-translacyjną modyfikację białek Rab. Otrzymane związki są badane pod względem ich aktywności w stosunku do enzymu Rab GGTaza oraz enzymów szlaku mewalonowego. |
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Zdefiniowanie miejsca oddziaływania inhibitorów z białkami w komórce – zastosowanie techniki “affinity-based protein profiling” |
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) 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Drugim kierunkiem naszych badań jest projektowanie i synteza próbników molekularnych, w celu określenia miejsca oddziaływania fosfonokarboksylanów z RGGT oraz potencjalnych oddziaływań z innymi białkami w komórce, z wykorzystaniem technik biologii chemicznej. Ułatwi to nie tylko projektowanie nowych inhibitorów RGGT, ale również pomoże przewidzieć potencjalne działania uboczne bądź synergiczne otrzymywanych związków z innymi białkami obecnymi w komórce. |
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Poprawa bioprzyswajalności – zastosowanie strategii prolekowej |
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) |
Ze względu na jonową strukturę analogów kwasów fosfonowych, leki z tej grupy związków cechuje niska bioprzyswajalność. W celu zamaskowania ich jonowego charakteru, część farmaceutyków tej klasy dostępna jest w postaci proleków (Tenofovir disoproxil fumarate – Viread; Adefovir dipivoxil – Hepsera; Sofosbuvir – użyty w kombinacji leków do leczenia żółtaczki typu C). Dlatego nasze zainteresowania rozszerzyliśmy o projektowanie i syntezę analogów typu prolekowego, które są badane pod kątem ich stabilności chemicznej oraz biologicznej. |
- Aleksandra Kaźmierczak, Damian Kusy, Sanna P. Niinivehmas, Joanna Gmach,Łukasz Joachimiak, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska Identification of the Privileged Position in the Imidazo[1,2-a]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors; J. Med. Chem. 2017, 60, 8781.
- J. Gmach, Ł. Joachimiak, K. M. Błażewska Aza-Michael addition of imidazole analogs Synthesis 2016, 48, 2681.
- S. Sun, K. M. Błażewska, A. P. Kadina, B. A. Kashemirov, X. Duan, J. T. Triffitt, J. E. Dunford, R. G. G. Russell, F. H. Ebetino, A. J. Roelofs, F. P. Coxon, M. W. Lundy, C. E. McKenna Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine Bioconjugate Chem. 2016, 27, 329.
- Ł. Joachimiak, Ł. Janczewski, J. Ciekot, J. Boratyński, K. Błażewska Applying prodrug strategy to α-phosphonocarboxylate inhibitors of Rab GGTase - synthesis and stability studies Org. Biomol. Chem. 2015, 13, 6844.
- Coxon, F.; Joachimiak, Ł.; Najumudeen, A. K.; Breen, G.; Gmach, J.;, Oetken-Lindholm, Ch.; Way, R.; Dunford, J.; Abankwa, D.; Błażewska, K. M. Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT Eur. J. Med. Chem. 2014, 84, 77-89.
- Błażewska, K. M. McKenna reaction – which oxygen attacks bromotrimethylsilane? J. Org. Chem. 2014, 79, 408.
- Roelofs, A.J.; Stewart, C. A.; Sun, S.; Błażewska, K. M.; Kashemirov, B. A.; McKenna, C. E.; Russell, R. G. G.; Rogers, M. J.; Lundy, M. W.; Ebetino, F. H.; Coxon, F. P. Influence of bone affinity on the skeletal distribution of fluorescently-labeled bisphosphonates in vivo J. Bone Mineral Res. 2012, 27, 835.
- Błażewska, K. M.; Ni, F.; Haiges, R.; Kashemirov, B. A.; Coxon, F.P.; Stewart, C. A.; Baron, R.; Rogers, M. J.; Seabra, M. C.; Ebetino, F. H.; McKenna, C. E. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors Eur. J. Med. Chem. 2011, 46, 4820.
- Błażewska, K. M.; Haiges, R.; Kashemirov, B. A.; Ebetino, F. H.; McKenna, C. E. A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent Chem. Commun. 2011, 47, 6395.
- C. E. McKenna, B. A. Kashemirov, K. M. Błażewska, I. Mallard-Favier, C. A. Stewart, J. Rojas, M. W. Lundy, F. H. Ebetino, R. A. Baron, M. C. Seabra, M. S. Marma, J. L. Bala, M. J. Rogers, F. P. Coxon Synthesis, Chiral HPLC Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-Imidazo[1,2-a]Pyridin-3-yl-2-Phosphonoproprionic Acid J. Med. Chem. 2010, 53, 3454.
- R. A. Baron, R. Tavare, A. C. Figueiredo, K. M. Błażewska, B. A. Kashemirov, C. E. McKenna, F. H. Ebetino, A. Taylor, M. J. Rogers, F. P. Coxon, M. C. Seabra Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab Geranylgeranyl Transferase J. Biol. Chem., 2009, 284, 254.
- Projekt badawczy (Narodowe Centrum Nauki, Sonata Bis 2014/14/E/ST5/00491): Projektowanie i synteza próbników Rab GGTazy i ich wykorzystanie do określenia miejsca oddziaływania fosfonokarboksylanowych inhibitorów z enzymem i identyfikacji potencjalnych oddziaływań ubocznych, okres realizacji 2015-2020; kierownik projektu: Katarzyna Błażewska.
- Projekt badawczy (Narodowe Centrum Nauki, Preludium 2016/23/N/ST5/03230): Synteza 2-fosfonokarboksylanów jako potencjalnych kowalencyjnych inhibitorów enzymu Rab geranylogeranylotransferazy; okres realizacji 2017-2019; kierownik projektu: Joanna Gmach; opiekun naukowy: Katarzyna Błażewska.
- Polsko-Amerykańska Komisja Fulbrighta: Development of the first probe for RabGGTase profiling – applying chemical biology for drug discovery, okres realizacji 12.2013-06.2014; kierownik projektu: Katarzyna Błażewska.
- Projekt badawczy własny (Ministerstwo Nauki i Szkolnictwa Wyższego, program Iuventus Plus IP2011 003771): Projektowanie i synteza pierwszych proleków fosfonokarboksylowych analogów bisfosfonianów - zwiększenie bioprzyswajalności fosfonokarboksylanów; okres realizacji 04.2012 - 11.2014; kierownik projektu: Katarzyna Błażewska.
- Projekt badawczy własny (Ministerstwo Nauki i Szkolnictwa Wyższego N N204 519839) Synteza nowych fosfonokarboksylowych analogów bisfosfonianów – poszukiwanie farmakoforu RabGGTazy (RGGT), okres realizacji: 31.08.2010 – 30.08.2013; kierownik projektu: Katarzyna Błażewska.
- Projekt badawczy własny (Ministerstwo Nauki i Szkolnictwa Wyższego, Iuventus Plus IP2010 003070): Wpływ lipofilowego charakteru fosfonokarboksylanów na ich bioprzyswajalność i aktywność względem RabGGTazy; okres realizacji: 2011; kierownik projektu: Katarzyna Błażewska.