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INSTITUTE OF ORGANIC CHEMISTRY

Research in laboratory headed by prof.Aleksandra Olma is focused on:

  • Design, synthesis, and biological evaluation of the modified peptide by non-coded amino acids (multifunctional α,α-disubstituted glycine,including α-alkylserines, β3-homo-amino acids, α-alkyl-β-substituted-alanines)

  • Synthesis of new, non-protein, multifunctional amino acids, (α-alkyl-β-azido-alanine, α-alkyl-β-1-piperidinyl (pyrrolidinyl, 4-morpholinyl) alanine, α-alkyl-β-halogeoalanines, α-alkyl-β-mercaptoalanines) using ring opening of N-protected α-alkiloseryn β-lactones using different nucleophiles

  • Relationships between structure and biological activity of bioactive peptide analogs containing conformationally constrained amino acids. Our attention is focused on opioid peptides bivalent ligands of opioid receptors. We use NMR techniques and molecular modeling to examine peptide conformations.

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